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Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis

  • Authors:
    • Jing-Xiu Li
    • Yang Li
    • Shu-Jun Yan
    • Bai-He Han
    • Zhao-Yan Song
    • Wei Song
    • Shi-Hao Liu
    • Ji-Wei Guo
    • Shuo Yin
    • Ye-Ping Chen
    • De-Jun Xia
    • Xin Li
    • Xue-Qi Li
    • En-Ze Jin
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Cardiology, Harbin First Hospital, Harbin, Heilongjiang 150001, P.R. China, Department of Pharmacy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 138-147
    |
    Published online on: December 29, 2017
       https://doi.org/10.3892/br.2017.1036
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Abstract

A challenge for antithrombotic treatment is patients who present with atrial fibrillation (AF) and acute coronary syndrome, particularly in patients who have undergone coronary percutaneous intervention with stenting (PCIS). In the present study, a total of nine observational trials published prior to July 2017 that investigated the effects of dual antiplatelet therapy (DAPT; aspirin + clopidogrel) and triple oral antithrombotic therapy (TOAT; DAPT + warfarin) among patients with AF concurrent to PCIS were collected from the Medline, Cochrane and Embase databases and conference proceedings of cardiology, gastroenterology and neurology meetings. A meta-analysis was performed using fixed- or random- effect models according to heterogeneity. The subgroups were also analyzed on the occurrence of major adverse cardiac events (MACE), stroke and bleeding events in the two treatment groups. Analysis of baseline characteristics indicated that there was no significant difference in the history of coexistent disease or conventional therapies between the DAPT and TOAT groups. The primary end point incidence was 2,588 patients in the DAPT group (n=13,773) and 871 patients in the TOAT group (n=5,262) following pooling of all nine trials. There was no statistically significant difference in the incidence of primary end points between the DAPT and TOAT groups. Odds ratio (OR)=0.96, 95% confidence interval (CI)=0.73-1.27, P=0.79, with heterogeneity between trials (I2=82%, P<0.00001). Subsequently, on subgroup analysis, the results indicated no increased risk of major bleeding or ischemic stroke in the DAPT or TOAT group. However, compared with the TOAT group, there was an apparent increased risk of MACE plus ischemic stroke in the DAPT group (OR=1.62, 95% CI=1.43‑1.83, P<0.00001) with heterogeneity between trials (I2=70%, P=0.01). In conclusion, the present meta-analysis suggests that TOAT (aspirin + clopidogrel + warfarin) therapy for patients with AF concurrent to PCIS significantly reduced the risk of MACE and stroke compared with DAPT (aspirin + clopidogrel) therapy. Further randomized controlled clinical trials are required to confirm the efficacy of the optimal antithrombotic therapy in patients with AF following PCIS.
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1 

Kanagaratnam L, Kowey P and Whalley D: Pharmacological therapy for rate and rhythm control for atrial fibrillation in 2017. Heart Lung Circ. 26:926–933. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Boriani G, Botto GL, Padeletti L, Santini M, Capucci A, Gulizia M, Ricci R, Biffi M, De Santo T, Corbucci G, et al: Italian AT-500 registry investigators: Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring. Stroke. 42:1768–1770. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Mazurek M, Shantsila E, Lane DA, Wolff A, Proietti M and Lip GYH: Guideline-adherent antithrombotic treatment improves outcomes in patients with atrial fibrillation: Insights from the community-based Darlington atrial fibrillation registry. Mayo Clin Proc. 92:pp. 1203–1213. 2017; View Article : Google Scholar : PubMed/NCBI

4 

Koene RJ, Win S, Naksuk N, Adatya SN, Rosenbaum AN, John R and Eckman PM: HAS-BLED and CHA2DS2-VASc scores as predictors of bleeding and thrombotic risk after continuous-flow ventricular assist device implantation. J Card Fail. 20:800–807. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Roldán V, Marín F, Manzano-Fernández S, Gallego P, Vílchez JA, Valdés M, Vicente V and Lip GY: The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation. J Am Coll Cardiol. 62:2199–2204. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Apostolakis S, Lane DA, Buller H and Lip GY: Comparison of the CHADS2, CHA2DS2-VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: The AMADEUS trial. Thromb Haemost. 110:1074–1079. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Angiolillo DJ, Goodman SG, Bhatt DL, Eikelboom JW, Price MJ, Moliterno DJ, Cannon CP, Tanguay JF, Granger CB, Mauri L, et al: Antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention: A North American Perspective-2016 Update. Circ Cardiovasc Interv. 9:92016. View Article : Google Scholar

8 

Kralev S, Schneider K, Lang S, Süselbeck T and Borggrefe M: Incidence and severity of coronary artery disease in patients with atrial fibrillation undergoing first-time coronary angiography. PLoS One. 6:e249642011. View Article : Google Scholar : PubMed/NCBI

9 

Nieuwlaat R, Capucci A, Camm AJ, Olsson SB, Andresen D, Davies DW, Cobbe S, Breithardt G, Le Heuzey JY, Prins MH, et al European Heart Survey Investigators, : Atrial fibrillation management: A prospective survey in ESC member countries: The Euro Heart Survey on Atrial Fibrillation. Eur Heart J. 26:2422–2434. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Nabauer M, Gerth A, Limbourg T, Schneider S, Oeff M, Kirchhof P, Goette A, Lewalter T, Ravens U, Meinertz T, et al: The registry of the German competence NETwork on atrial fibrillation: Patient characteristics and initial management. Europace. 11:423–434. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Rossini R, Musumeci G, Lettieri C, Molfese M, Mihalcsik L, Mantovani P, Sirbu V, Bass TA, Della Rovere F, Gavazzi A, et al: Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment requiring oral anticoagulant therapy. Am J Cardiol. 102:1618–1623. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Wang TY, Robinson LA, Ou FS, Roe MT, Ohman EM, Gibler WB, Smith SC Jr, Peterson ED and Becker RC: Discharge antithrombotic strategies among patients with acute coronary syndrome previously on warfarin anticoagulation: Physician practice in the CRUSADE registry. Am Heart J. 155:361–368. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Rubboli A, Colletta M, Valencia J, Capecchi A, Franco N, Zanolla L, La Vecchia L, Piovaccari G and Di Pasquale G; WARfarin and Coronary STENTing (WAR-STENT) study group, : Periprocedural management and in-hospital outcome of patients with indication for oral anticoagulation undergoing coronary artery stenting. J Interv Cardiol. 22:390–397. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Capodanno D and Angiolillo DJ: Management of antiplatelet and anticoagulant therapy in patients with atrial fibrillation in the setting of acute coronary syndromes or percutaneous coronary interventions. Circ Cardiovasc Interv. 7:113–124. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Authors/Task Force members, ; Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, et al: 2014 ESC/EACTS guidelines on myocardial revascularization: The task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 35:2541–2619. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jüniet P, et al: 2014 ESC/EACTS guidelines on myocardial revascularization. Rev Esp Cardiol. 68:4522015.

17 

Gurbel PA, Bliden KP, Hiatt BL and O'Connor CM: Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 107:2908–2913. 2003. View Article : Google Scholar : PubMed/NCBI

18 

James SK, Roe MT, Cannon CP, Cornel JH, Horrow J, Husted S, Katus H, Morais J, Steg PG, Storey RF, et al PLATO Study Group, : Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: Substudy from prospective randomised PLATelet inhibition and patient outcomes (PLATO) trial. BMJ. 342:35272011. View Article : Google Scholar

19 

Held C, Asenblad N, Bassand JP, Becker RC, Cannon CP, Claeys MJ, Harrington RA, Horrow J, Husted S, James SK, et al: Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: Results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 57:672–684. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Gwyn JCV, Thomas MR and Kirchhof P: Triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention: A viewpoint. Eur Heart J Cardiovasc Pharmacother. 3:157–162. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Lopes RD, Rao M, Simon DN, Thomas L, Ansell J, Fonarow GC, Gersh BJ, Go AS, Hylek EM, Kowey P, et al: Triple vs dual antithrombotic therapy in patients with atrial fibrillation and coronary artery disease. Am J Med. 129:592–599. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Pareek M, Bhatt DL, Ten Berg JM, Kristensen SD and Grove EL: Antithrombotic strategies for preventing long-term major adverse cardiovascular events in patients with non-valvular atrial fibrillation who undergo percutaneous coronary intervention. Expert Opin Pharmacother. 18:875–883. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Choi HI, Ahn JM, Kang SH, Lee PH, Kang SJ, Lee SW, Kim YH, Lee CW, Park SW, Park DW, et al: Prevalence, management, and long-term (6-year) outcomes of atrial fibrillation among patients receiving drug-eluting coronary stents. JACC Cardiovasc Interv. 10:1075–1085. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Lamberts M, Olesen JB, Ruwald MH, Hansen CM, Karasoy D, Kristensen SL, Køber L, Torp-Pedersen C, Gislason GH and Hansen ML: Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: A nationwide cohort study. Circulation. 126:1185–1193. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Kang DO, Yu CW, Kim HD, Cho JY, Joo HJ, Choi RK, Park JS, Lee HJ, Kim JS, Park JH, et al: Triple antithrombotic therapy versus dual antiplatelet therapy in patients with atrial fibrillation undergoing drug-eluting stent implantation. Coron Artery Dis. 26:372–380. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Gao F, Zhou YJ, Wang ZJ, Shen H, Liu XL, Nie B, Yan ZX, Yang SW, Jia de A and Yu M: Comparison of different antithrombotic regimens for patients with atrial fibrillation undergoing drug-eluting stent implantation. Circ J. 74:701–708. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Fosbol EL, Wang TY, Li S, Piccini JP, Lopes RD, Shah B, Mills RM, Klaskala W, Alexander KP, Thomas L, et al: Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction. Am Heart J. 163:720–728. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Manzano-Fernández S, Pastor FJ, Marín F, Cambronero F, Caro C, Pascual-Figal DA, Garrido IP, Pinar E, Valdés M and Lip GYH: Increased major bleeding complications related to triple antithrombotic therapy usage in patients with atrial fibrillation undergoing percutaneous coronary artery stenting. Chest. 134:559–567. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Maegdefessel L, Schlitt A, Faerber J, Bond SP, Messow CM, Buerke M, Raaz U, Werdan K, Muenzel T and Weiss C: Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention. A single-center experience. Med Klin (Munich). 103:628–632. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Hansen ML, Sørensen R, Clausen MT, Fog-Petersen ML, Raunsø J, Gadsbøll N, Gislason GH, Folke F, Andersen SS, Schramm TK, et al: Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med. 170:1433–1441. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Hess CN, Peterson ED, Peng SA, de Lemos JA, Fosbol EL, Thomas L, Bhatt DL, Saucedo JF and Wang TY: Use and outcomes of triple therapy among older patients with acute myocardial infarction and atrial fibrillation. J Am Coll Cardiol. 66:616–627. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Rao AK, Pratt C, Berke A, Jaffe A, Ockene I, Schreiber TL, Bell WR, Knatterud G, Robertson TL and Terrin ML: Thrombolysis in Myocardial Infarction (TIMI) Trial-phase I: Hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol. 11:1–11. 1988. View Article : Google Scholar : PubMed/NCBI

33 

Li JX, Jin EZ, Yu LH, Li Y, Liu NN, Dong YM, Li X and Li XQ: Oral N-acetylcysteine for prophylaxis of contrast-induced nephropathy in patients following coronary angioplasty: A meta-analysis. Exp Ther Med. 14:1568–1576. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Lip GY, Windecker S, Huber K, Kirchhof P, Marin F, Ten Berg JM, Haeusler KG, Boriani G, Capodanno D, Gilard M, et al: Document reviewers: Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: A joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Eur Heart J. 35:3155–3179. 2014. View Article : Google Scholar : PubMed/NCBI

36 

JCS Joint Working Group, . Guidelines for pharmacotherapy of atrial fibrillation (JCS 2013). Circ J. 78:1997–2021. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Heidenreich PA, Solis P, Estes NA III, Fonarow GC, Jurgens CY, Marine JE, McManus DD and McNamara RL: 2016 ACC/AHA Clinical performance and quality measures for adults with atrial fibrillation or atrial flutter: A report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am Coll Cardiol. 68:525–568. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Elewa H, Ahmed D and Barnes GD: Triple oral antithrombotic therapy in atrial fibrillation and coronary artery stenting: Searching for the best combination. Semin Thromb Hemost. 42:662–670. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, et al European Heart Rhythm Association, ; European Association for Cardio-Thoracic Surgery, : Guidelines for the management of atrial fibrillation: The Task Force for the management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 31:2369–2429. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Halvorsen S, Storey RF, Rocca B, Sibbing D, Ten Berg J, Grove EL, Weiss TW, Collet JP, Andreotti F, Gulba DC, et al ESC Working Group on Thrombosis, : Management of antithrombotic therapy after bleeding in patients with coronary artery disease and/or atrial fibrillation: Expert consensus paper of the European Society of Cardiology working group on thrombosis. Eur Heart J. 38:1455–1462. 2017.PubMed/NCBI

41 

Hart RG, Pearce LA and Aguilar MI: Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 146:857–867. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Peters RJ, Mehta SR, Fox KA, Zhao F, Lewis BS, Kopecky SL, Diaz R, Commerford PJ, Valentin V and Yusuf S; Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators, : Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the clopidogrel in unstable angina to prevent recurrent events (CURE) study. Circulation. 108:1682–1687. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Sabatine MS, Cannon CP, Gibson CM, López-Sendón JL, Montalescot G, Theroux P, Lewis BS, Murphy SA, McCabe CH and Braunwald E; Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28 Investigators, : Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: The PCI-CLARITY study. JAMA. 294:1224–1232. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, Garg S, Huber K, James S, Knuuti J, et al Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS), ; European Association for Percutaneous Cardiovascular Interventions (EAPCI), : Guidelines on myocardial revascularization. Eur Heart J. 31:2501–2555. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Wallentin L, James S, Storey RF, Armstrong M, Barratt BJ, Horrow J, Husted S, Katus H, Steg PG, Shah SH, et al: Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial. Lancet. 376:1320–1328. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Khayata M, Gabra JN, Nasser MF, Litman GI, Bhakta S and Raina R: Comparison of clopidogrel with prasugrel and ticagrelor in patients with acute coronary syndrome: Clinical outcomes from the national cardiovascular database ACTION registry. Cardiol Res. 8:105–110. 2017. View Article : Google Scholar : PubMed/NCBI

47 

O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, et al American College of Emergency Physicians, ; Society for Cardiovascular Angiography and Interventions, : 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 61:e78–e140. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Reed GW and Cannon CP: Triple oral antithrombotic therapy in atrial fibrillation and coronary artery stenting. Clin Cardiol. 36:585–594. 2013.PubMed/NCBI

49 

Dzeshka MS, Brown RA and Lip GY: Patients with atrial fibrillation undergoing percutaneous coronary intervention. Current concepts and concerns: Part I. Pol Arch Med Wewn. 125:73–81. 2015.PubMed/NCBI

50 

Dzeshka MS, Brown RA and Lip GY: Patients with atrial fibrillation undergoing percutaneous coronary intervention: Current concepts and concerns: Part II. Pol Arch Med Wewn. 125:172–180. 2015.PubMed/NCBI

51 

Lamberts M, Gislason GH, Olesen JB, Kristensen SL, Schjerning Olsen AM, Mikkelsen A, Christensen CB, Lip GY, Køber L, Torp-Pedersen C, et al: Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention. J Am Coll Cardiol. 62:981–989. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Thompson PL and Verheugt FW: Managing antithrombotic therapy in patients with both atrial fibrillation and coronary heart disease. Clin Ther. 36:1176–1181. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Gao F, Zhou YJ, Wang ZJ, Yang SW, Nie B, Liu XL, Jia A and Yan ZX: Meta-analysis of the combination of warfarin and dual antiplatelet therapy after coronary stenting in patients with indications for chronic oral anticoagulation. Int J Cardiol. 148:96–101. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Zhao HJ, Zheng ZT, Wang ZH, Li SH, Zhang Y, Zhong M and Zhang W: ‘Triple therapy’ rather than ‘triple threat’: A meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment. Chest. 139:260–270. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Saheb KJ, Deng BQ, Hu QS, Xie SL, Geng DF and Nie RQ: Triple antithrombotic therapy versus double antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients requiring chronic oral anticoagulation: A meta-analysis. Chin Med J (Engl). 126:2536–2542. 2013.PubMed/NCBI

56 

Andrade JG, Deyell MW, Khoo C, Lee M, Humphries K and Cairns JA: Risk of bleeding on triple antithrombotic therapy after percutaneous coronary intervention/stenting: A systematic review and meta-analysis. Can J Cardiol. 29:204–212. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Li Y, Yan S, Han B, Song Z, Song W, Liu S, Guo J, Yin S, Chen Y, Chen Y, et al: Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis. Biomed Rep 8: 138-147, 2018.
APA
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W. ... Jin, E. (2018). Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis. Biomedical Reports, 8, 138-147. https://doi.org/10.3892/br.2017.1036
MLA
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W., Liu, S., Guo, J., Yin, S., Chen, Y., Xia, D., Li, X., Li, X., Jin, E."Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis". Biomedical Reports 8.2 (2018): 138-147.
Chicago
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W., Liu, S., Guo, J., Yin, S., Chen, Y., Xia, D., Li, X., Li, X., Jin, E."Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis". Biomedical Reports 8, no. 2 (2018): 138-147. https://doi.org/10.3892/br.2017.1036
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Li Y, Yan S, Han B, Song Z, Song W, Liu S, Guo J, Yin S, Chen Y, Chen Y, et al: Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis. Biomed Rep 8: 138-147, 2018.
APA
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W. ... Jin, E. (2018). Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis. Biomedical Reports, 8, 138-147. https://doi.org/10.3892/br.2017.1036
MLA
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W., Liu, S., Guo, J., Yin, S., Chen, Y., Xia, D., Li, X., Li, X., Jin, E."Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis". Biomedical Reports 8.2 (2018): 138-147.
Chicago
Li, J., Li, Y., Yan, S., Han, B., Song, Z., Song, W., Liu, S., Guo, J., Yin, S., Chen, Y., Xia, D., Li, X., Li, X., Jin, E."Optimal antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: A systemic review and meta-analysis". Biomedical Reports 8, no. 2 (2018): 138-147. https://doi.org/10.3892/br.2017.1036
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