Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis

  • Authors:
    • Mahdi Atabaki
    • Mohammad Hashemi
    • Hamid Daneshvar
    • Ebrahim Alijani
  • View Affiliations

  • Published online on: January 9, 2017     https://doi.org/10.3892/br.2017.838
  • Pages: 251-255
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Abstract

Rheumatoid arthritis (RA) is a complex genetic disease. The lectin, galactoside‑binding, soluble, 3 (LGALS3) gene, encodes a member of the galectin family of carbohydrate binding proteins, and is one of the best examples of a non‑human leukocyte antigen gene associated with a risk for RA in various populations. In the current study, the association between LGALS3 rs4652 gene polymorphism and RA was examined. This case‑control study was performed on the 120 patients with RA and 120 healthy subjects. Genomic DNA was extracted from whole blood, and gene polymorphism was tested using a tetra‑primer amplification refractory mutation system‑polymerase chain reaction. The results demonstrated that LGALS3 rs4652 AC genotype increased the risk of RA (OR=11.622, 95% CI=4.473‑28.656; P=0.001) when compared with the AA genotype. However, the CC genotype and the C allele were not associated with RA. These findings indicated an association between LGALS3 rs4652 variation and the risk of RA in a sample of Iranian individuals. Further studies with larger sample sizes and populations of different ethnicities are required to validate our findings.
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February-2017
Volume 6 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Atabaki M, Hashemi M, Daneshvar H and Alijani E: Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomed Rep 6: 251-255, 2017
APA
Atabaki, M., Hashemi, M., Daneshvar, H., & Alijani, E. (2017). Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomedical Reports, 6, 251-255. https://doi.org/10.3892/br.2017.838
MLA
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6.2 (2017): 251-255.
Chicago
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6, no. 2 (2017): 251-255. https://doi.org/10.3892/br.2017.838