Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis

  • Authors:
    • Mahdi Atabaki
    • Mohammad Hashemi
    • Hamid Daneshvar
    • Ebrahim Alijani
  • View Affiliations / Copyright

    Affiliations: Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167-43181, Iran, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167-43181, Iran, Department of Immunology, Kerman University of Medical Sciences, Kerman, Kerman 76169-14115, Iran
  • Pages: 251-255
    |
    Published online on: January 9, 2017
       https://doi.org/10.3892/br.2017.838
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rheumatoid arthritis (RA) is a complex genetic disease. The lectin, galactoside‑binding, soluble, 3 (LGALS3) gene, encodes a member of the galectin family of carbohydrate binding proteins, and is one of the best examples of a non‑human leukocyte antigen gene associated with a risk for RA in various populations. In the current study, the association between LGALS3 rs4652 gene polymorphism and RA was examined. This case‑control study was performed on the 120 patients with RA and 120 healthy subjects. Genomic DNA was extracted from whole blood, and gene polymorphism was tested using a tetra‑primer amplification refractory mutation system‑polymerase chain reaction. The results demonstrated that LGALS3 rs4652 AC genotype increased the risk of RA (OR=11.622, 95% CI=4.473‑28.656; P=0.001) when compared with the AA genotype. However, the CC genotype and the C allele were not associated with RA. These findings indicated an association between LGALS3 rs4652 variation and the risk of RA in a sample of Iranian individuals. Further studies with larger sample sizes and populations of different ethnicities are required to validate our findings.
View Figures

Figure 1

Figure 2

View References

1 

Hashemi M, Atabaki M, Daneshvar H, Zakeri Z and Eskandari-Nasab E: Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Zahedan, Southeast Iran. Int J Immunogenet. 40:299–305. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Shalini P U, Debnath T, Jvs V, Kona LK, Kamaraju SR, Kancherla R and Chelluri LK: A study on FoxP3 and Tregs in paired samples of peripheral blood and synovium in rheumatoid arthritis. Cent Eur J Immunol. 40:431–436. 2015.

3 

Bowes J and Barton A: Recent advances in the genetics of RA susceptibility. Rheumatology (Oxford). 47:399–402. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Perricone C, Ceccarelli F and Valesini G: An overview on the genetic of rheumatoid arthritis: A never-ending story. Autoimmun Rev. 10:599–608. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Oliver JE and Silman AJ: Risk factors for the development of rheumatoid arthritis. Scand J Rheumatol. 35:169–174. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Amaya-Amaya J, Rojas-Villarraga A, Molano-Gonzalez N, Montoya-Sánchez L, Nath SK and Anaya JM: GDF15(MIC1) H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis. J Immunol Res. 2015:2707632015. View Article : Google Scholar : PubMed/NCBI

7 

Huang CM, Chen SY, Huang PH and Tsai FJ: Effect of MPG gene rs2858056 polymorphism, copy number variation, and level of serum MPG protein on the risk for rheumatoid arthritis. PLoS One. 10:e01206992015. View Article : Google Scholar : PubMed/NCBI

8 

Lee YH, Bae SC and Song GG: Meta-analysis of associations between functional prolactin −1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol. 34:683–690. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Sato S, St-Pierre C, Bhaumik P and Nieminen J: Galectins in innate immunity: Dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs). Immunol Rev. 230:172–187. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Menon RP and Hughes RC: Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex. Eur J Biochem. 264:569–576. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Liu FT, Patterson RJ and Wang JL: Intracellular functions of galectins. Biochim Biophys Acta. 1572:263–273. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Moutsatsos IK, Wade M, Schindler M and Wang JL: Endogenous lectins from cultured cells: Nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts. Proc Natl Acad Sci USA. 84:6452–6456. 1987. View Article : Google Scholar : PubMed/NCBI

13 

Dietz AB, Bulur PA, Knutson GJ, Matasić R and Vuk-Pavlović S: Maturation of human monocyte-derived dendritic cells studied by microarray hybridization. Biochem Biophys Res Commun. 275:731–738. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Truong MJ, Gruart V, Liu FT, Prin L, Capron A and Capron M: IgE-binding molecules (Mac-2/epsilon BP) expressed by human eosinophils. Implication in IgE-dependent eosinophil cytotoxicity. Eur J Immunol. 23:3230–3235. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Craig SS, Krishnaswamy P, Irani AM, Kepley CL, Liu FT and Schwartz LB: Immunoelectron microscopic localization of galectin-3, an IgE binding protein, in human mast cells and basophils. Anat Rec. 242:211–219. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Colnot C, Sidhu SS, Poirier F and Balmain N: Cellular and subcellular distribution of galectin-3 in the epiphyseal cartilage and bone of fetal and neonatal mice. Cell Mol Biol (Noisy-le-grand). 45:1191–1202. 1999.PubMed/NCBI

17 

Dagher SF, Wang JL and Patterson RJ: Identification of galectin-3 as a factor in pre-mRNA splicing. Proc Natl Acad Sci USA. 92:1213–1217. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Sasaki S, Bao Q and Hughes RC: Galectin-3 modulates rat mesangial cell proliferation and matrix synthesis during experimental glomerulonephritis induced by anti-Thy1.1 antibodies. J Pathol. 187:481–489. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Fukumori T, Takenaka Y, Oka N, Yoshii T, Hogan V, Inohara H, Kanayama HO, Kim HR and Raz A: Endogenous galectin-3 determines the routing of CD95 apoptotic signaling pathways. Cancer Res. 64:3376–3379. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Hoyer KK, Pang M, Gui D, Shintaku IP, Kuwabara I, Liu FT, Said JW, Baum LG and Teitell MA: An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas. Am J Pathol. 164:893–902. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Karlsson A, Christenson K, Matlak M, Björstad A, Brown KL, Telemo E, Salomonsson E, Leffler H and Bylund J: Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology. 19:16–20. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Nangiamakker P, Thompson E, Hogan C, Ochieng J and Raz A: Induction of tumorigenicity by galectin-3 in a nontumorigenic human breast-carcinoma cell-line. Int J Oncol. 7:1079–1087. 1995.PubMed/NCBI

23 

Hu CY, Chang SK, Wu CS, Tsai WI and Hsu PN: Galectin-3 gene (LGALS3) +292C allele is a genetic predisposition factor for rheumatoid arthritis in Taiwan. Clin Rheumatol. 30:1227–1233. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315–324. 1988. View Article : Google Scholar : PubMed/NCBI

25 

Hashemi M, Moazeni-Roodi AK, Fazaeli A, Sandoughi M, Bardestani GR, Kordi-Tamandani DM and Ghavami S: Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran. Genet Mol Res. 9:333–339. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hashemi M, Moazeni-Roodi AK, Fazaeli A, Sandoughi M, Taheri M, Bardestani GR, Zakeri Z, Kordi-Tamandani DM and Ghavami S: The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis. Genet Mol Res. 9:1735–1741. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Sandoughi M, Fazaeli A, Bardestani G and Hashemi M: Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, southeast Iran. Ann Saudi Med. 31:171–173. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Dumic J, Dabelic S and Flögel M: Galectin-3: An open-ended story. Biochim Biophys Acta. 1760:616–635. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Hsu DK, Hammes SR, Kuwabara I, Greene WC and Liu FT: Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3. Am J Pathol. 148:1661–1670. 1996.PubMed/NCBI

30 

Kimata H: Enhancement of IgE production in B cells by neutrophils via galectin-3 in IgE-associated atopic eczema/dermatitis syndrome. Int Arch Allergy Immunol. 128:168–170. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Yamaoka A, Kuwabara I, Frigeri LG and Liu FT: A human lectin, galectin-3 (epsilon bp/Mac-2), stimulates superoxide production by neutrophils. J Immunol. 154:3479–3487. 1995.PubMed/NCBI

32 

Kuwabara I and Liu FT: Galectin-3 promotes adhesion of human neutrophils to laminin. J Immunol. 156:3939–3944. 1996.PubMed/NCBI

33 

Filer A, Bik M, Parsonage GN, Fitton J, Trebilcock E, Howlett K, Cook M, Raza K, Simmons DL, Thomas AM, et al: Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways. Arthritis Rheum. 60:1604–1614. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Gao P, Simpson JL, Zhang J and Gibson PG: Galectin-3: Its role in asthma and potential as an anti-inflammatory target. Respir Res. 14:1362013. View Article : Google Scholar : PubMed/NCBI

35 

Hu Y, Yéléhé-Okouma M, Ea HK, Jouzeau JY and Reboul P: Galectin-3: A key player in arthritis. Joint Bone Spine. May 26–2016.(Epub ahead of print).

36 

Krześlak A and Lipińska A: Galectin-3 as a multifunctional protein. Cell Mol Biol Lett. 9:305–328. 2004.

37 

Ochieng J, Furtak V and Lukyanov P: Extracellular functions of galectin-3. Glycoconj J. 19:527–535. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Matarrese P, Tinari N, Semeraro ML, Natoli C, Iacobelli S and Malorni W: Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis. FEBS Lett. 473:311–315. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Shou J, Bull CM, Li L, Qian HR, Wei T, Luo S, Perkins D, Solenberg PJ, Tan SL, Chen XY, et al: Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Arthritis Res Ther. 8:R282006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Atabaki M, Hashemi M, Daneshvar H and Alijani E: Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomed Rep 6: 251-255, 2017.
APA
Atabaki, M., Hashemi, M., Daneshvar, H., & Alijani, E. (2017). Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomedical Reports, 6, 251-255. https://doi.org/10.3892/br.2017.838
MLA
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6.2 (2017): 251-255.
Chicago
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6, no. 2 (2017): 251-255. https://doi.org/10.3892/br.2017.838
Copy and paste a formatted citation
x
Spandidos Publications style
Atabaki M, Hashemi M, Daneshvar H and Alijani E: Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomed Rep 6: 251-255, 2017.
APA
Atabaki, M., Hashemi, M., Daneshvar, H., & Alijani, E. (2017). Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis. Biomedical Reports, 6, 251-255. https://doi.org/10.3892/br.2017.838
MLA
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6.2 (2017): 251-255.
Chicago
Atabaki, M., Hashemi, M., Daneshvar, H., Alijani, E."Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis". Biomedical Reports 6, no. 2 (2017): 251-255. https://doi.org/10.3892/br.2017.838
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team