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Article

Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan

  • Authors:
    • Jiajing Cai
    • Yan Cai
    • Qiang Ma
    • Fan Chang
    • Lei Xu
    • Guoyuan Zhang
    • Xiaolan Guo
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Translational Medicine Research Center, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
  • Pages: 217-222
    |
    Published online on: January 11, 2017
       https://doi.org/10.3892/br.2017.840
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Abstract

The p53 tumor suppressor gene is key in tumor development and progression, and the single nucleotide polymorphism (SNP) of the p53 gene codon 72 (p53Arg/Pro) changes the structure of the protein. In addition, it affects its activity, which may affect cancer risk. The aim of the present study was to investigate the association between p53 codon 72 polymorphism and susceptibility to hepatocellular carcinoma (HCC) in a Chinese population from northeast Sichuan. A total of 342 HCC patients and 347 non‑cancer control subjects were recruited, and the polymorphism of p53 codon 72 was measured by TaqMan® minor groove binder fluorescent quantitative polymerase chain reaction assay. The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.7% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (χ2=0.14; P=0.93). Upon further stratification with smoking, alcohol consumption, gender and hepatitis B virus (HBV) infection, no risk increasing genotype was identified. However, interactions between p53 codon 72 SNP and smoking, alcohol consumption and HBV infection may increase the risk of HCC [smoking odds ratio (OR), 2.00; 95% confidence interval (CI), 1.21‑3.29; alcohol consumption OR, 1.87; 95% CI, 1.08‑3.26; HBV infection OR, 1.84; 95% CI, 1.10‑3.08]. No significant association was identified between p53 codon 72 polymorphism and HCC, and it may not have an independent effect on the susceptibility to HCC in a Chinese population from northeast Sichuan. However, interaction between genetic factors and environment exposure significantly increased the risk of HCC.
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1 

Zhang S, Zheng R, Zeng H and Chen W: The incidence differences among sex, geographical areas and mean age of diagnosis for liver cancer in China, 1989-2008. Zhonghua Yu Fang Yi Xue Za Zhi. 48:355–360. 2014.(In Chinese). PubMed/NCBI

2 

Ma X, Liu XX and Wu XP: Incidence and mortality of cancer in the registered regions of Sichuan in 2009. J Prev Med Inf. 29:918–923. 2013.

3 

Chen JG, Lu JH, Zhu YR, Zhu J and Zhang YH: A thirty-one year prospective follow-up program on the HBsAg carrier state and primary liver cancer in Qidong, China. Zhonghua Liu Xing Bing Xue Za Zhi. 31:721–726. 2010.(In Chinese). PubMed/NCBI

4 

Cheok CF, Verma CS, Baselga J and Lane DP: Translating p53 into the clinic. Nat Rev Clin Oncol. 8:25–37. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hu S, Zhao L, Yang J and Hu M: The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: Evidence from a meta-analysis of 15 studies with 3,704 cases. Tumour Biol. 35:3647–3656. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Forner A and Bruix J: Biomarkers for early diagnosis of hepatocellular carcinoma. Lancet Oncol. 13:750–751. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Insinga A, Cicalese A, Faretta M, Gallo B, Albano L, Ronzoni S, Furia L, Viale A and Pelicci PG: DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. Proc Natl Acad Sci USA. 110:3931–3936. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Leu JI, Murphy ME and George DL: The p53 codon 72 polymorphism modifies the cellular response to inflammatory challenge in the liver. J Liver. 2:1172013.PubMed/NCBI

9 

Zhang YY, Yu HP and Fan XJ: Association of p53 codon72 polymorphism and risk of hepatocellular carcinoma. J Clin Oncol. 18:189–193. 2012.

10 

Mou NN and Zhang L: Effects of p53 gene codon 72 Arg/Pro polymorphisms on susceptibility of hepatocellular carcinoma in patients with hepatitis B virus infection in Shandong Province. J Hepatopancreatobilliary Surg. 25:381–384. 2013.

11 

Zhu ZZ, Cong WM, Zhu GS, Liu SF, Xian ZH, Wu WQ, Zhang XZ, Wang YH and Wu MC: Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 22:632–635. 2005.(In Chinese). PubMed/NCBI

12 

Ezzikouri S, El Feydi AE, Chafik A, Benazzouz M, El Kihal L, Afifi R, Hassar M, Pineau P and Benjelloun S: The Pro variant of the p53 codon 72 polymorphism is associated with hepatocellular carcinoma in Moroccan population. Hepatol Res. 37:748–754. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Sümbül AT, Akkız H, Bayram S, Bekar A, Akgöllü E and Sandıkçı M: p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: A case-control study. Mol Biol Rep. 39:1639–1647. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Yoon YJ, Chang HY, Ahn SH, Kim JK, Park YK, Kang DR, Park JY, Myoung SM, Kim DY, Chon CY, et al: MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Carcinogenesis. 29:1192–1196. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Di Vuolo V, Buonaguro L, Izzo F, Losito S, Botti G, Buonaguro FM and Tornesello ML: TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients. Infect Agent Cancer. 6:132011. View Article : Google Scholar

16 

Lu SQ, Jia ST and Luo Y: Recent advances in mutant p53 and novel personalized strategies for cancer therapy. Yi Chuan. 33:539–548. 2011.(In Chinese). View Article : Google Scholar : PubMed/NCBI

17 

Lv L, Wang P, Zhou X and Sun B: Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk. Tumour Biol. 34:1451–1459. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Zhang XF, Wei T, Liu XM, Liu C and Lv Y: Impact of cigarette smoking on outcome of hepatocellular carcinoma after surgery in patients with hepatitis B. PLoS One. 9:e850772014. View Article : Google Scholar : PubMed/NCBI

19 

Li Y, Yang H and Cao J: Association between alcohol consumption and cancers in the Chinese population - a systematic review and meta-analysis. PLoS One. 6:e187762011. View Article : Google Scholar : PubMed/NCBI

20 

Kapoor NR, Ahuja R, Shukla SK and Kumar V: The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression. FEBS Lett. 587:1287–1292. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Park SG, Min JY, Chung C, Hsieh A and Jung G: Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx. Cancer Lett. 282:229–237. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Hartwell HJ, Petrosky KY, Fox JG, Horseman ND and Rogers AB: Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice. Proc Natl Acad Sci USA. 111:11455–11460. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Keng VW, Largaespada DA and Villanueva A: Why men are at higher risk for hepatocellular carcinoma? J Hepatol. 57:453–454. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM and Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 317:121–124. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cai J, Cai Y, Ma Q, Chang F, Xu L, Zhang G and Guo X: Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan. Biomed Rep 6: 217-222, 2017.
APA
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., & Guo, X. (2017). Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan. Biomedical Reports, 6, 217-222. https://doi.org/10.3892/br.2017.840
MLA
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., Guo, X."Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan". Biomedical Reports 6.2 (2017): 217-222.
Chicago
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., Guo, X."Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan". Biomedical Reports 6, no. 2 (2017): 217-222. https://doi.org/10.3892/br.2017.840
Copy and paste a formatted citation
x
Spandidos Publications style
Cai J, Cai Y, Ma Q, Chang F, Xu L, Zhang G and Guo X: Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan. Biomed Rep 6: 217-222, 2017.
APA
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., & Guo, X. (2017). Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan. Biomedical Reports, 6, 217-222. https://doi.org/10.3892/br.2017.840
MLA
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., Guo, X."Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan". Biomedical Reports 6.2 (2017): 217-222.
Chicago
Cai, J., Cai, Y., Ma, Q., Chang, F., Xu, L., Zhang, G., Guo, X."Association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a Chinese population from northeast Sichuan". Biomedical Reports 6, no. 2 (2017): 217-222. https://doi.org/10.3892/br.2017.840
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