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Review

Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review)

  • Authors:
    • Xinyu Liu
    • Shixue Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R. China, Emergency Department, Rizhao Chinese Medicine Hospital, Rizhao, Shandong 276800, P.R. China
  • Pages: 140-145
    |
    Published online on: January 12, 2017
       https://doi.org/10.3892/br.2017.841
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Abstract

The morbidity of diabetes mellitus has been increasing annually. As a progressive metabolic disorder, chronic complications occur in the late stage of diabetes. In addition, cardiovascular diseases account for the major cause of morbidity and mortality among the diabetic population worldwide. Diabetic cardiomyopathy (DCM) is a type of diabetic heart disease. Patients with DCM show symptoms and signs of heart failure while no specific cause, such as coronary disease, hypertension, alcohol consumption, or other structural heart diseases has been identified. The pathogenesis of DCM is complex and has not been well understood until recently. MicroRNAs (miRs) belong to a novel family of highly conserved, short, non‑coding, single‑stranded RNA molecules that regulate transcriptional and post‑transcriptional gene expression. Furthermore, recent studies have demonstrated an association between miRs and DCM. In the current review, the role of miRs in the pathogenesis of DCM is summarized. It was concluded that miRs contribute to the regulation of cardiomyocyte hypertrophy, myocardial fibrosis, cardiomyocyte apoptosis, mitochondrial dysfunction, myocardial electrical remodeling, epigenetic modification and various other pathophysiological processes of DCM. These studies may provide novel insights into targets for prevention and treatment of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X and Liu S: Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review). Biomed Rep 6: 140-145, 2017.
APA
Liu, X., & Liu, S. (2017). Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review). Biomedical Reports, 6, 140-145. https://doi.org/10.3892/br.2017.841
MLA
Liu, X., Liu, S."Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review)". Biomedical Reports 6.2 (2017): 140-145.
Chicago
Liu, X., Liu, S."Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review)". Biomedical Reports 6, no. 2 (2017): 140-145. https://doi.org/10.3892/br.2017.841
Copy and paste a formatted citation
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Spandidos Publications style
Liu X and Liu S: Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review). Biomed Rep 6: 140-145, 2017.
APA
Liu, X., & Liu, S. (2017). Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review). Biomedical Reports, 6, 140-145. https://doi.org/10.3892/br.2017.841
MLA
Liu, X., Liu, S."Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review)". Biomedical Reports 6.2 (2017): 140-145.
Chicago
Liu, X., Liu, S."Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (Review)". Biomedical Reports 6, no. 2 (2017): 140-145. https://doi.org/10.3892/br.2017.841
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