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Article

Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors

  • Authors:
    • In‑Suk Bae
    • Choong‑Hyun Kim
    • Jae‑Min Kim
    • Jin‑Hwan Cheong
    • Je‑Il Ryu
    • Myung‑Hoon Han
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Hanyang University Guri Hospital, Guri‑si, Gyeonggi‑do 11923, Republic of Korea
  • Pages: 396-400
    |
    Published online on: February 17, 2017
       https://doi.org/10.3892/br.2017.861
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Abstract

Apoptosis, whose mechanism remains unclear, is regulated by multiple factors. B‑cell lymphoma 2 (Bcl‑2) is a well‑known anti‑apoptotic mediator. Survivin is also a recently recognized novel family inhibitor of apoptosis protein, which inhibits apoptosis via a pathway distinct from Bcl‑2 family members. Survivin and Bcl‑2 are expressed in various types of human cancer. In the present study, survivin and Bcl‑2 expression were characterized in glial cell tumors, and the correlation with pathological malignancy and anti‑apoptotic properties were investigated. Fifty‑eight patients who had undergone surgical resection for glial cell tumors were evaluated. The pathological types of glial cell tumors were categorized according to the World Health Organization classification. Survivin and Bcl‑2 expression levels were investigated by western blot analysis, and apoptosis was detected by DNA fragmentation analysis. The anti‑apoptotic rate of glial cell tumors was calculated in tumor samples according to the expression of survivin and Bcl‑2 or co‑expression. Survivin was characterized in 60.3%, and Bcl‑2 was expressed in 43.1% of glioma samples. Co‑expression of survivin and Bcl‑2 was observed in 25.9% of the tumor specimens. Survivin expression in astrocytic tumors was identified to be significantly associated with the pathological grade (P<0.05); however, Bcl‑2 was not (P>0.05). Anti‑apoptotic rate of glial cell tumors were detected in 91.4, 92.0 and 100% of patients exhibiting survivin, Bcl‑2 or co‑expression, respectively. However, the difference in anti‑apoptotic frequency between the three groups was not identified to be statistically significant (P>0.05). The present study suggests that survivin expression is correlated with pathological grades of gliomas. In addition, the expression of survivin or Bcl‑2 exerts potent anti‑apoptotic properties in gliomas. Thus, survivin or Bcl‑2 may serve as potential targets for inducing the apoptosis of gliomas.
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1 

Ahmed R, Oborski MJ, Hwang M, Lieberman FS and Mountz JM: Malignant gliomas: Current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods. Cancer Manag Res. 6:149–170. 2014.PubMed/NCBI

2 

Corwin D, Holdsworth C, Rockne RC, Trister AD, Mrugala MM, Rockhill JK, Stewart RD, Phillips M and Swanson KR: Toward patient-specific, biologically optimized radiation therapy plans for the treatment of glioblastoma. PLoS One. 8:e791152013. View Article : Google Scholar : PubMed/NCBI

3 

Kanamori M, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, et al: Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. Neuro-oncol. 17:555–565. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Hu B, Emdad L, Bacolod MD, Kegelman TP, Shen XN, Alzubi MA, Das SK, Sarkar D and Fisher PB: Astrocyte elevated gene-1 interacts with Akt isoform 2 to control glioma growth, survival, and pathogenesis. Cancer Res. 74:7321–7332. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Würth R, Pattarozzi A, Gatti M, Bajetto A, Corsaro A, Parodi A, Sirito R, Massollo M, Marini C, Zona G, et al: Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt. Cell Cycle. 12:145–156. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Yamamoto T and Tanigawa N: The role of survivin as a new target of diagnosis and treatment in human cancer. Med Electron Microsc. 34:207–212. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T and Tanigawa N: Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res. 58:5071–5074. 1998.PubMed/NCBI

8 

Louis DN, Ohgaki H, Wiestler OD and Cavenee WK: World Health Organization histological classification of tumours of the central nervous system. International Agency for Research on Cancer; Lyon: 2007

9 

Altieri DC: The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol Med. 7:542–547. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Altieri DC: Validating survivin as a cancer therapeutic target. Nat Rev Cancer. 3:46–54. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Ashhab Y, Alian A, Polliack A, Panet A and Ben Yehuda D: Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett. 495:56–60. 2001. View Article : Google Scholar : PubMed/NCBI

12 

O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC and Altieri DC: Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci USA. 97:13103–13107. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Tanaka K, Iwamoto S, Gon G, Nohara T, Iwamoto M and Tanigawa N: Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin Cancer Res. 6:127–134. 2000.PubMed/NCBI

14 

Kleinschmidt-DeMasters BK, Heinz D, McCarthy PJ, Bobak JB, Lillehei KO, Shroyer AL and Shroyer KR: Survivin in glioblastomas. Protein and messenger RNA expression and comparison with telomerase levels. Arch Pathol Lab Med. 127:826–833. 2003.PubMed/NCBI

15 

Sasaki T, Lopes MBS, Hankins GR and Helm GA: Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system. Acta Neuropathol. 104:105–109. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Kajiwara Y, Yamasaki F, Hama S, Yahara K, Yoshioka H, Sugiyama K, Arita K and Kurisu K: Expression of survivin in astrocytic tumors: Correlation with malignant grade and prognosis. Cancer. 97:1077–1083. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ and Loeffler JS: Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol. 20:1063–1068. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Xie D, Zeng YX, Wang HJ, Wen JM, Tao Y, Sham JS and Guan XY: Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma. Br J Cancer. 94:108–114. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Altieri DC: Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer. 8:61–70. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Kanwar RK, Cheung CH, Chang JY and Kanwar JR: Recent advances in anti-survivin treatments for cancer. Curr Med Chem. 17:1509–1515. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Plati J, Bucur O and Khosravi-Far R: Apoptotic cell signaling in cancer progression and therapy. Integr Biol. 3:279–296. 2011. View Article : Google Scholar

22 

Zhang SL, Zhao CQ, Lin B, Li Y and Gao H: Expression of survivin gene and its relation with the expression of bcl-2 and bax protein in epithelial ovarian cancer. Zhonghua Fu Chan Ke Za Zhi. 38:203–206. 2003.(In Chinese). PubMed/NCBI

23 

Rödel F, Hoffmann J, Grabenbauer GG, Papadopoulos T, Weiss C, Günther K, Schick C, Sauer R and Rödel C: High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol. 178:426–435. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Gradilone A, Gazzaniga P, Ribuffo D, Scarpa S, Cigna E, Vasaturo F, Bottoni U, Innocenzi D, Calvieri S, Scuderi N, et al: Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients. J Clin Oncol. 21:306–312. 2003. View Article : Google Scholar : PubMed/NCBI

25 

O'Connor DS, Schechner JS, Adida C, Mesri M, Rothermel AL, Li F, Nath AK, Pober JS and Altieri DC: Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol. 156:393–398. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Mesri M, Morales-Ruiz M, Ackermann EJ, Bennett CF, Pober JS, Sessa WC and Altieri DC: Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol. 158:1757–1765. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bae IS, Kim CH, Kim JM, Cheong JH, Ryu JI and Han MH: Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors. Biomed Rep 6: 396-400, 2017.
APA
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., & Han, M. (2017). Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors. Biomedical Reports, 6, 396-400. https://doi.org/10.3892/br.2017.861
MLA
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., Han, M."Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors". Biomedical Reports 6.4 (2017): 396-400.
Chicago
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., Han, M."Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors". Biomedical Reports 6, no. 4 (2017): 396-400. https://doi.org/10.3892/br.2017.861
Copy and paste a formatted citation
x
Spandidos Publications style
Bae IS, Kim CH, Kim JM, Cheong JH, Ryu JI and Han MH: Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors. Biomed Rep 6: 396-400, 2017.
APA
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., & Han, M. (2017). Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors. Biomedical Reports, 6, 396-400. https://doi.org/10.3892/br.2017.861
MLA
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., Han, M."Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors". Biomedical Reports 6.4 (2017): 396-400.
Chicago
Bae, I., Kim, C., Kim, J., Cheong, J., Ryu, J., Han, M."Correlation of survivin and B‑cell lymphoma 2 expression with pathological malignancy and anti‑apoptotic properties of glial cell tumors". Biomedical Reports 6, no. 4 (2017): 396-400. https://doi.org/10.3892/br.2017.861
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