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Article

Serum miR-20a is a promising biomarker for gastric cancer

  • Authors:
    • Ruirui Yang
    • Yun Fu
    • Ying Zeng
    • Mengqin Xiang
    • Yufang Yin
    • Li Li
    • Haifan Xu
    • Jing Zhong
    • Xi Zeng
  • View Affiliations / Copyright

    Affiliations: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China, School of Nursing, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA, Department of Surgical Oncology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, Institute of Clinical Medicine, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 429-434
    |
    Published online on: February 20, 2017
       https://doi.org/10.3892/br.2017.862
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Abstract

Gastric cancer (GC) is a common type of cancer, particularly in China. Numerous studies have demonstrated that circulating microRNAs (miRNAs) have potential applications as noninvasive biomarkers for cancer diagnosis and prognosis. Microarray-based serum miRNA profiling was performed on the serum of 12 paired pre- and post-operative GC patients to screen differentially expressed serum miRNAs. Twelve different serum miRNAs between pre- and post‑operative GC patients were identified. Those miRNAs were verified by real-time quantitative polymerase chain reaction in 110 paired pre- and post-operative serum samples from 55 GC patients. miR-20a was confirmed and demonstrated potential as a GC-associated biomarker. Furthermore, the levels of serum miR-20a were significantly different between GC, nasopharyngeal cancer, colorectal carcinoma, breast cancer and non-cancerous controls. In addition, it was found that serum miR-20a levels correlated with age, tumor stage, differentiated degree and lymph node metastasis in GC. Survival analysis indicated that GC patients with elevated levels of serum miR-20a had poor survival. Thus, serum miR-20a may serve as a molecular marker for diagnosis, evaluating therapeutic efficacy and prognosis, as well as monitoring recurrence in GC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Yang R, Fu Y, Zeng Y, Xiang M, Yin Y, Li L, Xu H, Zhong J and Zeng X: Serum miR-20a is a promising biomarker for gastric cancer. Biomed Rep 6: 429-434, 2017.
APA
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L. ... Zeng, X. (2017). Serum miR-20a is a promising biomarker for gastric cancer. Biomedical Reports, 6, 429-434. https://doi.org/10.3892/br.2017.862
MLA
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L., Xu, H., Zhong, J., Zeng, X."Serum miR-20a is a promising biomarker for gastric cancer". Biomedical Reports 6.4 (2017): 429-434.
Chicago
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L., Xu, H., Zhong, J., Zeng, X."Serum miR-20a is a promising biomarker for gastric cancer". Biomedical Reports 6, no. 4 (2017): 429-434. https://doi.org/10.3892/br.2017.862
Copy and paste a formatted citation
x
Spandidos Publications style
Yang R, Fu Y, Zeng Y, Xiang M, Yin Y, Li L, Xu H, Zhong J and Zeng X: Serum miR-20a is a promising biomarker for gastric cancer. Biomed Rep 6: 429-434, 2017.
APA
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L. ... Zeng, X. (2017). Serum miR-20a is a promising biomarker for gastric cancer. Biomedical Reports, 6, 429-434. https://doi.org/10.3892/br.2017.862
MLA
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L., Xu, H., Zhong, J., Zeng, X."Serum miR-20a is a promising biomarker for gastric cancer". Biomedical Reports 6.4 (2017): 429-434.
Chicago
Yang, R., Fu, Y., Zeng, Y., Xiang, M., Yin, Y., Li, L., Xu, H., Zhong, J., Zeng, X."Serum miR-20a is a promising biomarker for gastric cancer". Biomedical Reports 6, no. 4 (2017): 429-434. https://doi.org/10.3892/br.2017.862
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