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Article

Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901

  • Authors:
    • Yinliang Qi
    • Jianfeng Ruan
    • Mei Wang
    • Yuanchang Dai
    • Qing Zhou
    • Shuyu Gui
    • Sumei Zhang
    • Yuan Wang
  • View Affiliations / Copyright

    Affiliations: General Department of Hyperbaric Oxygen, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China, Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230011, P.R. China
  • Pages: 475-479
    |
    Published online on: March 8, 2017
       https://doi.org/10.3892/br.2017.869
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Abstract

Hyperbaric oxygen (HBO) has been previously identified as an effective adjunct treatment option for the management of brain injury, diabetic ulcers and chronic wounds. However, the roles of HBO as an adjunctive therapy for tumors remain controversial. The present research project was performed to explore the effects of HBO treatment on proliferation, autophagy and endoplasmic reticulum stress response of the gastric cancer cell line, SGC7901. The present study demonstrated that, after subjecting SGC7901 cells to HBO treatment, the increase in cell proliferation was significant, compared with that of the control group. In addition, there was a significant increase in LC3‑phosphatidylethanolamine conjugate (LC3‑II) level, as well as binding immunoglobulin protein level, and a significant decrease in CCAAT‑enhancer‑binding protein homologous protein level. These suggested that hyperbaric oxygen treatment alone may promote proliferation and cell survival of gastric cancer cell SGC7901, and inhibit apoptosis through regulating cell autophagy and oxidative stress.
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Copy and paste a formatted citation
Spandidos Publications style
Qi Y, Ruan J, Wang M, Dai Y, Zhou Q, Gui S, Zhang S and Wang Y: Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901. Biomed Rep 6: 475-479, 2017.
APA
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S. ... Wang, Y. (2017). Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901. Biomedical Reports, 6, 475-479. https://doi.org/10.3892/br.2017.869
MLA
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S., Zhang, S., Wang, Y."Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901". Biomedical Reports 6.4 (2017): 475-479.
Chicago
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S., Zhang, S., Wang, Y."Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901". Biomedical Reports 6, no. 4 (2017): 475-479. https://doi.org/10.3892/br.2017.869
Copy and paste a formatted citation
x
Spandidos Publications style
Qi Y, Ruan J, Wang M, Dai Y, Zhou Q, Gui S, Zhang S and Wang Y: Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901. Biomed Rep 6: 475-479, 2017.
APA
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S. ... Wang, Y. (2017). Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901. Biomedical Reports, 6, 475-479. https://doi.org/10.3892/br.2017.869
MLA
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S., Zhang, S., Wang, Y."Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901". Biomedical Reports 6.4 (2017): 475-479.
Chicago
Qi, Y., Ruan, J., Wang, M., Dai, Y., Zhou, Q., Gui, S., Zhang, S., Wang, Y."Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901". Biomedical Reports 6, no. 4 (2017): 475-479. https://doi.org/10.3892/br.2017.869
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