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Article

Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice

  • Authors:
    • Ahmet Mutlu
    • Oguz Mutlu
    • Guner Ulak
    • Furuzan Akar
    • Havva Kaya
    • Faruk Erden
    • Pelin Tanyeri
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Uskudar State Hospital, Istanbul 34672, Turkey, Department of Pharmacology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, Turkey, Department of Pharmacology, Sakarya University, Faculty of Medicine, Sakarya 54100, Turkey
  • Pages: 567-570
    |
    Published online on: March 23, 2017
       https://doi.org/10.3892/br.2017.879
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Abstract

Cognitive dysfunction is commonly observed in schizophrenic patients and the administration of antipsychotic treatments results in different outcomes. Although the typical antipsychotic treatments, such as haloperidol, appear to be unable to improve cognition dysfunction, the atypical antipsychotic drugs (quetiapine, aripiprazole and iloperidone) exert a beneficial effect. The purpose of the current study was to investigate the effects of atypical antipsychotics on olfactory memory in mice, utilizing the social transmission of food preference (STFP) tests to evaluate the effects of drugs on MK‑801‑induced cognitive dysfunction. Female BALB/c mice were treated with quetiapine (5 and 10 mg/kg), aripiprazole (3 and 6 mg/kg), iloperidone (0.5 and 1 mg/kg) or MK‑801 (0.1 mg/kg) alone or concurrently prior to retention sessions of STFP tests. In the STFP tests, quetiapine (10 mg/kg; P<0.05), aripiprazole (3 and 6 mg/kg; P<0.01 and P<0.001, respectively), iloperidone (0.5 and 1 mg/kg; P<0.01 and P<0.001, respectively) and MK‑801 (P<0.001) significantly decreased cued/total food eaten (%). Quetiapine (5 mg/kg; P<0.05) significantly increased MK‑801‑induced decreases in cued/total food eaten (%), while aripiprazole and iloperidone demonstrated no significant effects. The results revealed that all of the drugs disturbed olfactory memory in the naive mice; however, only quetiapine reversed MK‑801‑induced memory impairment in the STFP test.
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Copy and paste a formatted citation
Spandidos Publications style
Mutlu A, Mutlu O, Ulak G, Akar F, Kaya H, Erden F and Tanyeri P: Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice. Biomed Rep 6: 567-570, 2017.
APA
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., & Tanyeri, P. (2017). Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice. Biomedical Reports, 6, 567-570. https://doi.org/10.3892/br.2017.879
MLA
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., Tanyeri, P."Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice". Biomedical Reports 6.5 (2017): 567-570.
Chicago
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., Tanyeri, P."Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice". Biomedical Reports 6, no. 5 (2017): 567-570. https://doi.org/10.3892/br.2017.879
Copy and paste a formatted citation
x
Spandidos Publications style
Mutlu A, Mutlu O, Ulak G, Akar F, Kaya H, Erden F and Tanyeri P: Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice. Biomed Rep 6: 567-570, 2017.
APA
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., & Tanyeri, P. (2017). Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice. Biomedical Reports, 6, 567-570. https://doi.org/10.3892/br.2017.879
MLA
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., Tanyeri, P."Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice". Biomedical Reports 6.5 (2017): 567-570.
Chicago
Mutlu, A., Mutlu, O., Ulak, G., Akar, F., Kaya, H., Erden, F., Tanyeri, P."Superior effects of quetiapine compared with aripiprazole and iloperidone on MK-801-induced olfactory memory impairment in female mice". Biomedical Reports 6, no. 5 (2017): 567-570. https://doi.org/10.3892/br.2017.879
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