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Review

Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)

  • Authors:
    • Amir Sonnenblick
    • Tamar Zahavi
  • View Affiliations / Copyright

    Affiliations: Sharett Institute of Oncology, Hadassah‑Hebrew University Medical Center, Jerusalem 91120, Israel
  • Pages: 545-548
    |
    Published online on: March 30, 2017
       https://doi.org/10.3892/br.2017.882
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Abstract

The long-term prognosis following resection of hepatocellular carcinoma (HCC) remains unsatisfactory as a result of a high incidence of recurrence. Prevention of recurrence is the most important strategy to improve the long-term survival results. The role of hepatectomy itself, as an accelerator of carcinogenesis, has not been adequately evaluated in HCC patients. Studies in animal models have revealed a link between liver regeneration under chronic inflammation and hepatic tumorigenesis. Inhibiting different signal transduction pathways during liver regeneration without compromising the ability of the liver to regenerate appears to be a rational strategy and may decrease HCC development and recurrence. If this hypothesis is proven using animal models, this strategy could be evaluated in future clinical trials in humans.
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Copy and paste a formatted citation
Spandidos Publications style
Sonnenblick A and Zahavi T: Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomed Rep 6: 545-548, 2017.
APA
Sonnenblick, A., & Zahavi, T. (2017). Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomedical Reports, 6, 545-548. https://doi.org/10.3892/br.2017.882
MLA
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6.5 (2017): 545-548.
Chicago
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6, no. 5 (2017): 545-548. https://doi.org/10.3892/br.2017.882
Copy and paste a formatted citation
x
Spandidos Publications style
Sonnenblick A and Zahavi T: Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomed Rep 6: 545-548, 2017.
APA
Sonnenblick, A., & Zahavi, T. (2017). Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomedical Reports, 6, 545-548. https://doi.org/10.3892/br.2017.882
MLA
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6.5 (2017): 545-548.
Chicago
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6, no. 5 (2017): 545-548. https://doi.org/10.3892/br.2017.882
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