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Review

Role of the microRNA-29 family in fibrotic skin diseases (Review)

  • Authors:
    • Duygu Harmanci
    • Erdogan Pekcan Erkan
    • Ayse Kocak
    • Gul Guner Akdogan
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, Graduate School of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey, Department of Medical Genetics, Medicum, University of Helsinki, 00014 Helsinki, Finland, Department of Medical Biochemistry, School of Medicine, Izmir University of Economics, Balcova 35330, Izmir, Turkey
  • Pages: 599-604
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    Published online on: May 3, 2017
       https://doi.org/10.3892/br.2017.900
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Abstract

Fibrotic skin diseases are characterized by the accumulation of collagen. The hallmarks of fibrotic skin diseases are unbalanced fibroblast proliferation and differentiation, extracellular matrix production and transforming growth factor‑β signalling. Numerous studies have investigated the possibility that microRNAs (miRNAs or miRs) are involved in the pathogenesis of certain fibrotic diseases, including skin, heart, lung and liver diseases. miRNAs are a class of small non‑coding RNAs, which modify gene expression by binding to target messenger RNA (mRNA) and blocking the translation or inducing the degradation of target mRNA. The biological relevance of miRNAs has been investigated in physiological and pathological conditions, and there is increasing evidence that the miR‑29 family is associated with fibrotic diseases. The aim of the present review is to provide an up‑to‑date summary of current knowledge on the latest developments associated with the miR‑29 family and fibrotic skin diseases.
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Spandidos Publications style
Harmanci D, Erkan EP, Kocak A and Akdogan GG: Role of the microRNA-29 family in fibrotic skin diseases (Review). Biomed Rep 6: 599-604, 2017.
APA
Harmanci, D., Erkan, E.P., Kocak, A., & Akdogan, G.G. (2017). Role of the microRNA-29 family in fibrotic skin diseases (Review). Biomedical Reports, 6, 599-604. https://doi.org/10.3892/br.2017.900
MLA
Harmanci, D., Erkan, E. P., Kocak, A., Akdogan, G. G."Role of the microRNA-29 family in fibrotic skin diseases (Review)". Biomedical Reports 6.6 (2017): 599-604.
Chicago
Harmanci, D., Erkan, E. P., Kocak, A., Akdogan, G. G."Role of the microRNA-29 family in fibrotic skin diseases (Review)". Biomedical Reports 6, no. 6 (2017): 599-604. https://doi.org/10.3892/br.2017.900
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Spandidos Publications style
Harmanci D, Erkan EP, Kocak A and Akdogan GG: Role of the microRNA-29 family in fibrotic skin diseases (Review). Biomed Rep 6: 599-604, 2017.
APA
Harmanci, D., Erkan, E.P., Kocak, A., & Akdogan, G.G. (2017). Role of the microRNA-29 family in fibrotic skin diseases (Review). Biomedical Reports, 6, 599-604. https://doi.org/10.3892/br.2017.900
MLA
Harmanci, D., Erkan, E. P., Kocak, A., Akdogan, G. G."Role of the microRNA-29 family in fibrotic skin diseases (Review)". Biomedical Reports 6.6 (2017): 599-604.
Chicago
Harmanci, D., Erkan, E. P., Kocak, A., Akdogan, G. G."Role of the microRNA-29 family in fibrotic skin diseases (Review)". Biomedical Reports 6, no. 6 (2017): 599-604. https://doi.org/10.3892/br.2017.900
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