Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
August-2017 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review)

  • Authors:
    • Chun Wang
    • Jianping Gong
    • Hao Wu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Yongchuan Hospital of Traditional Chinese Medicine, Chongqing 402161, P.R. China, Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China
  • Pages: 95-104
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/br.2017.926
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, the morbidity of which closely correlates with diversity of ethnicity, minority, family and location. Its histology spans from simple steatosis, to nonalcoholic steatohepatitis, which ultimately results in fibrosis, cirrhosis and hepatocellular carcinoma. The accelerating prevalence of NAFLD is due to an incremental incidence of metabolic syndrome that is distinguished by dyslipidemia, glucose impairment, obesity, excessive oxidative stress and adipocytokine impairment. Additionally, the pathogenesis of NAFLD is thought to be a multifactorial and complicated disease associated with lifestyle habits, nutritional factors and genetics. However, the pathogenesis and underlying mechanism in the development of NAFLD caused by genetics remains unclear. People have been increasingly emphasizing on the relationship between NAFLD and gene polymorphisms in recent years, with the aim of having a comprehensive elucidation of associated gene polymorphisms influencing the pathogenesis of the disease. In the current article, the authors attempted to critically summarize the most recently identified gene polymorphisms from the facets of glucose metabolism, fatty acid metabolism, oxidative stress and related cytokines in NAFLD that contribute to promoting the progression of the disease.
View Figures

Figure 1

View References

1 

Zhang X, Harmsen WS, Mettler TA, Kim WR, Roberts RO, Therneau TM, Roberts LR and Chaiteerakij R: Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology. 60:2008–2016. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Day CP and James OF: Steatohepatitis: A tale of two ‘hits’? Gastroenterology. 114:842–845. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Anstee QM, Daly AK and Day CP: Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis. 31:128–146. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Lake AD, Novak P, Hardwick RN, Flores-Keown B, Zhao F, Klimecki WT and Cherrington NJ: The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease. Toxicol Sci. 137:26–35. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Anderson N and Borlak J: Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev. 60:311–357. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Naik A, Belič A, Zanger UM and Rozman D: Molecular interactions between NAFLD and xenobiotic metabolism. Front Genet. 4:22013. View Article : Google Scholar : PubMed/NCBI

7 

Zhang D, Liu ZX, Choi CS, Tian L, Kibbey R, Dong J, Cline GW, Wood PA and Shulman GI: Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc Natl Acad Sci USA. 104:17075–17080. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Duvnjak M, Lerotić I, Barsić N, Tomasić V, Jukić L Virović and Velagić V: Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol. 13:4539–4550. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Bradbury MW and Berk PD: Lipid metabolism in hepatic steatosis. Clin Liver Dis. 8639–671. (xi)2004. View Article : Google Scholar : PubMed/NCBI

10 

de Almeida IT, Cortez-Pinto H, Fidalgo G, Rodrigues D and Camilo ME: Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin Nutr. 21:219–223. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Malaguarnera L, Di Rosa M, Zambito AM, dell'Ombra N, Nicoletti F and Malaguarnera M: Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease. Gut. 55:1313–1320. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K and Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 116:1784–1792. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Müssig K, Heni M, Thamer C, Kantartzis K, Machicao F, Stefan N, Fritsche A, Häring HU and Staiger H: The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention. Diabetologia. 53:504–509. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Dongiovanni P, Valenti L, Rametta R, Daly AK, Nobili V, Mozzi E, Leathart JB, Pietrobattista A, Burt AD, Maggioni M, et al: Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease. Gut. 59:267–273. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Parola M and Marra F: Adipokines and redox signaling: Impact on fatty liver disease. Antioxid Redox Signal. 15:461–483. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Tokushige K, Hashimoto E, Noto H, Yatsuji S, Taniai M, Torii N and Shiratori K: Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease. J Gastroenterol. 44:976–982. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Wong VW, Wong GL, Tsang SW, Hui AY, Chan AW, Choi PC, So WY, Tse AM, Chan FK, Sung JJ, et al: Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people. J Gastroenterol Hepatol. 23:914–921. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Wang BF, Wang Y, Ao R, Tong J and Wang BY: AdipoQ T45 G and G276 T polymorphisms and susceptibility to nonalcoholic fatty liver disease among Asian populations: A meta-analysis and meta-regression. J Clin Lab Anal. 30:47–57. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Hashemi M, Bojd H Hanafi, Nasab E Eskandari, Bahari A, Hashemzehi NA, Shafieipour S, Narouie B, Taheri M and Ghavami S: Association of adiponectin rs1501299 and rs266729 gene polymorphisms with nonalcoholic fatty liver disease. Hepat Mon. 13:e95272013. View Article : Google Scholar : PubMed/NCBI

20 

Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE and Rossetti L: Role of resistin in diet-induced hepatic insulin resistance. J Clin Invest. 114:232–239. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Singhal NS, Patel RT, Qi Y, Lee YS and Ahima RS: Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab. 295:E331–E338. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Tomaru T, Steger DJ, Lefterova MI, Schupp M and Lazar MA: Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins. J Biol Chem. 284:6116–6125. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Kumar S, Gupta V, Srivastava N, Gupta V, Mishra S, Mishra S, Shankar M Natu, Roy U, Chandra A, Negi MP, et al: Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women. Immunol Lett. 162(2 Pt B): 287–291. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Zhang LY, Jin YJ, Jin QS, Lin LY, Zhang DD and Kong LL: Association between resistin +299A/A genotype and nonalcoholic fatty liver disease in Chinese patients with type 2 diabetes mellitus. Gene. 529:340–344. 2013. View Article : Google Scholar : PubMed/NCBI

25 

El-Shal AS, Pasha HF and Rashad NM: Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients. Gene. 515:233–238. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Lu H, Sun J, Sun L, Shu X, Xu Y and Xie D: Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. J Gastroenterol Hepatol. 24:228–232. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Swellam M and Hamdy N: Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor. IUBMB Life. 64:180–186. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Zain SM, Mohamed Z, Mahadeva S, Cheah PL, Rampal S, Chin KF, Mahfudz AS, Basu RC, Tan HL and Mohamed R: Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene. J Gastroenterol Hepatol. 28:873–879. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Brondani LA, Assmann TS, de Souza BM, Bouças AP, Canani LH and Crispim D: Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1–3 genes with body mass index variability. PLoS One. 9:e964112014. View Article : Google Scholar : PubMed/NCBI

30 

Mexitalia M, Yamauchi T, Utari A, Sjarif DR, Subagio HW, Soemantri A and Ishida T: The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children. J Pediatr Endocrinol Metab. 26:441–447. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xu YP, Liang L, Wang CL, Fu JF, Liu PN, Lv LQ and Zhu YM: Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children. World J Gastroenterol. 19:5897–5903. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Hashemi M, Hoseini H, Yaghmaei P, Moazeni-Roodi A, Bahari A, Hashemzehi N and Shafieipour S: Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease. DNA Cell Biol. 30:569–575. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Tian Y, Li H, Wang S, Yan J, Chen Z, Li Z, Feng H, Zhou H and Ouyang D: Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects. Lipids. 50:275–282. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Peng XE, Wu YL, Lu QQ, Hu ZJ and Lin X: MTTP polymorphisms and susceptibility to non-alcoholic fatty liver disease in a Han Chinese population. Liver Int. 34:118–128. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Gambino R, Cassader M, Pagano G, Durazzo M and Musso G: Polymorphism in microsomal triglyceride transfer protein: A link between liver disease and atherogenic postprandial lipid profile in NASH? Hepatology. 45:1097–1107. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Wolff E, Vergnes MF, Defoort C, Planells R, Portugal H, Nicolay A and Lairon D: Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women. Genes Nutr. 6:71–79. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Siqueira ER, Oliveira CP, Correa-Giannella ML, Stefano JT, Cavaleiro AM, Fortes MA, Muniz MT, Silva FS, Pereira LM and Carrilho FJ: MTP −493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients. Braz J Med Biol Res. 45:72–77. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Dongiovanni P, Rametta R, Fracanzani AL, Benedan L, Borroni V, Maggioni P, Maggioni M, Fargion S and Valenti L: Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: Α case control study. BMC Gastroenterol. 10:1022010. View Article : Google Scholar : PubMed/NCBI

39 

Stienstra R, Saudale F, Duval C, Keshtkar S, Groener JE, van Rooijen N, Staels B, Kersten S and Müller M: Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology. 51:511–522. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Chen S, Li Y, Li S and Yu C: A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio. J Gastroenterol Hepatol. 23:1415–1418. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Naito H, Yamanoshita O, Kamijima M, Katoh T, Matsunaga T, Lee CH, Kim H, Aoyama T, Gonzalez FJ and Nakajima T: Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men. Pharmacogenet Genomics. 16:569–577. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Domenici FA, Brochado MJ, Martinelli AL, Zucoloto S, da Cunha SF and Vannucchi H: Peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms in nonalcoholic fatty liver disease: A study in Brazilian patients. Gene. 529:326–331. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Sahebkar A: Does PPARγ2 gene Pro12Ala polymorphism affect nonalcoholic fatty liver disease risk? Evidence from a meta-analysis. DNA Cell Biol. 32:188–198. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Yang Z, Wen J, Li Q, Tao X, Ye Z, He M, Zhang W, Huang Y, Chen L, Ling C, et al: PPARG gene Pro12Ala variant contributes to the development of non-alcoholic fatty liver in middle-aged and older Chinese population. Mol Cell Endocrinol. 348:255–259. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Cao CY, Li YY, Zhou YJ, Nie YQ and Wan YJ: The C-681G polymorphism of the PPAR-γ gene is associated with susceptibility to non-alcoholic fatty liver disease. Tohoku J Exp Med. 227:253–262. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Gawrieh S, Marion MC, Komorowski R, Wallace J, Charlton M, Kissebah A, Langefeld CD and Olivier M: Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD. Dig Dis Sci. 57:952–957. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Bien CM and Espenshade PJ: Sterol regulatory element binding proteins in fungi: Hypoxic transcription factors linked to pathogenesis. Eukaryot Cell. 9:352–359. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T, et al: Down-regulation of SREBP-1c is associated with the development of burned-out NASH. J Hepatol. 53:724–731. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Wang Y, Tong J, Chang B, Wang BF, Zhang D and Wang BY: Relationship of SREBP-2 rs2228314 G>C polymorphism with nonalcoholic fatty liver disease in a Han Chinese population. Genet Test Mol Biomarkers. 18:653–657. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Sun S, Wang M, Song H, Wu T, Wei H, He S, Ding Z and Ji G: SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome. J Genet. 92:565–570. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Younossi ZM, Gorreta F, Ong JP, Schlauch K, Del Giacco L, Elariny H, van Meter A, Younoszai A, Goodman Z, Baranova A, et al: Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. Liver Int. 25:760–771. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Al-Serri A, Anstee QM, Valenti L, Nobili V, Leathart JB, Dongiovanni P, Patch J, Fracanzani A, Fargion S, Day CP, et al: The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies. J Hepatol. 56:448–454. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Krautbauer S, Eisinger K, Lupke M, Wanninger J, Ruemmele P, Hader Y, Weiss TS and Buechler C: Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease. Exp Mol Pathol. 95:330–335. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Nahon P, Sutton A, Rufat P, Ziol M, Akouche H, Laguillier C, Charnaux N, Ganne-Carrié N, Grando-Lemaire V, N'Kontchou G, et al: Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Hepatology. 50:1484–1493. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Kathirvel E, Chen P, Morgan K, French SW and Morgan TR: Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver. J Gastroenterol Hepatol. 25:1136–1143. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Liu W, Tian F, Dai L and Chai Y: Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: A meta-analysis. Mol Biol Rep. 41:7645–7650. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Khan AJ, Ruwali M, Choudhuri G, Mathur N, Husain Q and Parmar D: Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. Mutat Res. 664:55–63. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Handa P, Morgan-Stevenson V, Maliken BD, Nelson JE, Washington S, Westerman M, Yeh MM and Kowdley KV: Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice. Am J Physiol Gastrointest Liver Physiol. 310:G117–G127. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Nelson JE, Brunt EM and Kowdley KV: Nonalcoholic Steatohepatitis Clinical Research Network: Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations. Hepatology. 56:1730–1740. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Lee SH, Jeong SH, Lee D, Lee JH, Hwang SH, Cho YA, Park YS, Hwang JH, Kim JW, Kim N, et al: An epidemiologic study on the incidence and significance of HFE mutations in a Korean cohort with nonalcoholic fatty liver disease. J Clin Gastroenterol. 44:e154–e161. 2010.PubMed/NCBI

61 

Nelson JE, Yeh MM and Kowdley KV: Relationship of C282Y HFE mutations, hepatic iron deposition and histologic features in patients with nonalcoholic fatty liver disease. Gastroenterology. 140:S938–S939. 2011.

62 

Valenti L, Fracanzani AL, Bugianesi E, Dongiovanni P, Galmozzi E, Vanni E, Canavesi E, Lattuada E, Roviaro G, Marchesini G, et al: HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease. Gastroenterology. 138:905–912. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M and Wallace M: Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol. 47:571–579. 2007. View Article : Google Scholar : PubMed/NCBI

64 

Nagaya T, Tanaka N, Kimura T, Komatsu M and Tanaka E: Enhanced expression of toll-like receptor 4 and MyD88 is associated with disease progression in human nonalcoholic fatty liver disease. Gastroenterology. 140:S–978. 2011.

65 

Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Königsrainer A, Maier KP, Bischoff SC and Bergheim I: Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr. 138:1452–1455. 2008.PubMed/NCBI

66 

Peng D, Jiang F, Zhang R, Tang S, Chen M, Yan J, Sun X, Luo Y, Hu C and Jia W: Association of Toll-like Receptor 4 Gene polymorphisms with susceptibility to type 2 diabetes mellitus in the Chinese population. J Diabetes. 7:485–492. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Yin YW, Wang Q, Sun QQ, Hu AM and Liu HL: Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabetes mellitus: A meta-analysis of 15,059 subjects. Diabetes Res Clin Pract. 107:338–347. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Kiziltas S, Ata P, Colak Y, Mesçi B, Senates E, Enc F, Ulasoglu C, Tuncer I and Oguz A: TLR4 gene polymorphism in patients with nonalcoholic fatty liver disease in comparison to healthy controls. Metab Syndr Relat Disord. 12:165–170. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Tache D, Bogdan F, Pisoschi C, Baniţă M, Stănciulescu C, Fusaru AM and Comănescu V: Evidence for the involvement of TGF-β1-CTGF axis in liver fibrogenesis secondary to hepatic viral infection. Rom J Morphol Embryol. 52:409–412. 2011.PubMed/NCBI

70 

Xiang TX, Cheng N, Li XN and Wu XP: Association between transforming growth factor-β1 polymorphisms and hepatocellular cancer risk: A meta-analysis. Hepatol Res. 42:583–590. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Mohy A and Fouad A: Role of transforming growth factor-β1 in serum and − 509 C>T promoter gene polymorphism in development of liver cirrhosis in Egyptian patients. Meta Gene. 2:631–637. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Falleti E, Fabris C, Toniutto P, Fontanini E, Cussigh A, Bitetto D, Fornasiere E, Avellini C, Minisini R and Pirisi M: TGF-β1 genotypes in cirrhosis: Relationship with the occurrence of liver cancer. Cytokine. 44:256–261. 2008. View Article : Google Scholar : PubMed/NCBI

73 

Dai CY, Chuang WL, Lee LP, Pan WC, Huang JF, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, et al: Association between transforming growth factor-beta 1 polymorphism and virologic characteristics of chronic hepatitis C. Transl Res. 152:151–156. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli G and Fargion S: Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology. 122:274–280. 2002. View Article : Google Scholar : PubMed/NCBI

75 

Tokushige K, Takakura M, Tsuchiya-Matsushita N, Taniai M, Hashimoto E and Shiratori K: Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis. J Hepatol. 46:1104–1110. 2007. View Article : Google Scholar : PubMed/NCBI

76 

Wang JK, Feng ZW, Li YC, Li QY and Tao XY: Association of tumor necrosis factor-α gene promoter polymorphism at sites −308 and −238 with non-alcoholic fatty liver disease: A meta-analysis. J Gastroenterol Hepatol. 27:670–676. 2012. View Article : Google Scholar : PubMed/NCBI

77 

Wei Y, Liu F, Li B, Chen X, Ma Y, Yan L, Wen T, Xu M, Wang W and Yang J: Polymorphisms of tumor necrosis factor-alpha and hepatocellular carcinoma risk: A HuGE systematic review and meta-analysis. Dig Dis Sci. 56:2227–2236. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Marginean O, Banescu C, Duicu C, Marginean M Oana and Marginean C: The role of interleukin-6 gene 572G/C polymorphism in child obesity. Clin Nutr. 33:S1172014. View Article : Google Scholar

79 

Giannitrapani L, Soresi M, Balasus D, Licata A and Montalto G: Genetic association of interleukin-6 polymorphism (−174 G/C) with chronic liver diseases and hepatocellular carcinoma. World J Gastroenterol. 19:2449–2455. 2013. View Article : Google Scholar : PubMed/NCBI

80 

Deng Y, Li M, Wang J, Xie L, Li T, He Y, Lu Q, Li R, Tan A, Qin X, et al: Susceptibility to hepatocellular carcinoma in the Chinese population-associations with interleukin-6 receptor polymorphism. Tumour Biol. 35:6383–6388. 2014. View Article : Google Scholar : PubMed/NCBI

81 

Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G and Bellentani S: Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study. Hepatology. 42:44–52. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang C, Gong J and Wu H: Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review). Biomed Rep 7: 95-104, 2017.
APA
Wang, C., Gong, J., & Wu, H. (2017). Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review). Biomedical Reports, 7, 95-104. https://doi.org/10.3892/br.2017.926
MLA
Wang, C., Gong, J., Wu, H."Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review)". Biomedical Reports 7.2 (2017): 95-104.
Chicago
Wang, C., Gong, J., Wu, H."Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review)". Biomedical Reports 7, no. 2 (2017): 95-104. https://doi.org/10.3892/br.2017.926
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Gong J and Wu H: Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review). Biomed Rep 7: 95-104, 2017.
APA
Wang, C., Gong, J., & Wu, H. (2017). Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review). Biomedical Reports, 7, 95-104. https://doi.org/10.3892/br.2017.926
MLA
Wang, C., Gong, J., Wu, H."Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review)". Biomedical Reports 7.2 (2017): 95-104.
Chicago
Wang, C., Gong, J., Wu, H."Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease (Review)". Biomedical Reports 7, no. 2 (2017): 95-104. https://doi.org/10.3892/br.2017.926
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team