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The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis

  • Authors:
    • Wenxian Zheng
    • Shuisheng Zhang
    • Shenfeng Zhang
    • Li Min
    • Yihong Wang
    • Jian Xie
    • Yong Hou
    • Xiufang Tian
    • Jian Cheng
    • Kun Liu
    • Deguo Xu
    • Xinshuang Yu
    • Zhen Liu
    • Yajuan Lv
    • Ning Liang
    • Jiandong Zhang
    • Fengjun Liu
    • Yuan Tian
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People Hospital, Shanghai 200233, P.R. China, Department of Abdominal Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China, Department of Oncology, Zaozhuang Municipal Hospital of Shandong Province, Zaozhuang, Shandong 277101, P.R. China, Department of Gastroenterology, Beijing Medical University, National Clinical Center for Digestive Disease Center, Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, P.R. China, Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 133-142
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/br.2017.934
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Abstract

The aim of the present study was to evaluate the relationship between tumor necrosis factor‑α (TNF‑α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta‑analysis was performed to assess the association between TNF‑α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non‑cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random‑effects model. TNF‑α 308 polymorphisms indicated a significant relationship with gastric cancer risk among a normal population [GA/AA vs. GG; 1.17 (1.10‑1.23)]. In analysis stratified by ethnicity, TNF‑α 238 displayed an association with gastric cancer risk in eastern populations [GA/AA vs. GG: 1.24 (1.02‑1.50)], but not in western populations [GA/AA vs. GG: 0.96 (0.79‑1.18)]. The overall ORs (95% CIs) for TNF‑α 857, TNF‑α 1031 and TNF‑α 863 were 1.13 (1.04‑1.24), 0.94 (0.85‑1.05) and 0.89 (0.78‑1.02), respectively, under dominant genetic model comparison. Among the above three SNPs, only TNF‑α 857 was robustly associated with gastric cancer inclination, and this association remained consistently robust when limited to non‑cardia gastric cancers [GA/AA vs. GG: 1.16 (1.03‑1.31)]. TNF‑α 308 and TNF‑α 857 genotypes were potential risk factors of statistical significance in gastric cancer, and TNF‑α 238 indicated to be significantly associated with gastric cancer risk only in eastern populations. TNF‑α 1031 and TNF‑α 863 were not significantly associated with gastric cancer risk.
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Spandidos Publications style
Zheng W, Zhang S, Zhang S, Min L, Wang Y, Xie J, Hou Y, Tian X, Cheng J, Liu K, Liu K, et al: The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis. Biomed Rep 7: 133-142, 2017.
APA
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J. ... Tian, Y. (2017). The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis. Biomedical Reports, 7, 133-142. https://doi.org/10.3892/br.2017.934
MLA
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J., Hou, Y., Tian, X., Cheng, J., Liu, K., Xu, D., Yu, X., Liu, Z., Lv, Y., Liang, N., Zhang, J., Liu, F., Tian, Y."The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis". Biomedical Reports 7.2 (2017): 133-142.
Chicago
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J., Hou, Y., Tian, X., Cheng, J., Liu, K., Xu, D., Yu, X., Liu, Z., Lv, Y., Liang, N., Zhang, J., Liu, F., Tian, Y."The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis". Biomedical Reports 7, no. 2 (2017): 133-142. https://doi.org/10.3892/br.2017.934
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Spandidos Publications style
Zheng W, Zhang S, Zhang S, Min L, Wang Y, Xie J, Hou Y, Tian X, Cheng J, Liu K, Liu K, et al: The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis. Biomed Rep 7: 133-142, 2017.
APA
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J. ... Tian, Y. (2017). The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis. Biomedical Reports, 7, 133-142. https://doi.org/10.3892/br.2017.934
MLA
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J., Hou, Y., Tian, X., Cheng, J., Liu, K., Xu, D., Yu, X., Liu, Z., Lv, Y., Liang, N., Zhang, J., Liu, F., Tian, Y."The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis". Biomedical Reports 7.2 (2017): 133-142.
Chicago
Zheng, W., Zhang, S., Zhang, S., Min, L., Wang, Y., Xie, J., Hou, Y., Tian, X., Cheng, J., Liu, K., Xu, D., Yu, X., Liu, Z., Lv, Y., Liang, N., Zhang, J., Liu, F., Tian, Y."The relationship between tumor necrosis factor‑α polymorphisms and gastric cancer risk: An updated meta‑analysis". Biomedical Reports 7, no. 2 (2017): 133-142. https://doi.org/10.3892/br.2017.934
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