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Article

Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury

  • Authors:
    • Liwei Li
    • Changtai Zhu
    • Ye Yuan
    • Zhiqiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Transfusion, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
  • Pages: 148-152
    |
    Published online on: July 4, 2017
       https://doi.org/10.3892/br.2017.936
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Abstract

Transfusion‑related acute lung injury (TRALI) is a serious complication characterized by the acute onset of non‑cardiogenic pulmonary edema following transfusion of blood products. It is not known whether rapamycin has an effect on TRALI that is caused by blood transfusion. The aim of the present study was to determine the effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury. Animal models of TRALI and acute pancreatitis‑associated lung injury (APALI) were prepared using Sprague-Dawley rats and histopathological examination of lung tissues was used to validate acute lung injury models. Peripheral blood neutrophils were isolated and early stage apoptosis of neutrophils was detected by flow cytometry. The animal models of TRALI and APALI were constructed successfully. Early stage apoptosis of neutrophils increased in the TRALI group and decreased in the APALI group (P<0.05), while the apoptosis rates in rapamycin intervention TRALI and APALI groups were not significantly different compared to the rate in the control group (P>0.05). In conclusion, early stage apoptosis of neutrophils in TRALI was different from that in APALI, and rapamycin had a limited protective effect on TRALI and APALI in Sprague‑Dawley rats.
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1 

Menis M, Anderson SA, Forshee RA, McKean S, Johnson C, Warnock R, Gondalia R, Mintz PD, Holness L, Worrall CM, et al: Transfusion-related acute lung injury and potential risk factors among the inpatient US elderly as recorded in Medicare claims data, during 2007 through 2011. Transfusion. 54:2182–2193. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Abraham E: Neutrophils and acute lung injury. Crit Care Med. 31:S195–S199. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Fielhaber JA, Carroll SF, Dydensborg AB, Shourian M, Triantafillopoulos A, Harel S, Hussain SN, Bouchard M, Qureshi ST and Kristof AS: Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis. J Immunol. 188:4535–4542. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Mossman JA, Biancani LM, Zhu CT and Rand DM: Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila. Genetics. 203:463–484. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Sharif R, Dawra R, Wasiluk K, Phillips P, Dudeja V, Kurt-Jones E, Finberg R and Saluja A: Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Gut. 58:813–819. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Yuan YE, Liwei L and Zhiqiang L: Effects of rapamycin on expressions of m TOR down-stream proteins p70s6k/p-p70s6k and pulmonary histopathological changes in transfusion-related acute lung injury rat model. Chin J Blood Transfus. 29:251–254. 2016.

7 

Hay N and Sonenberg N: Upstream and downstream of mTOR. Genes Dev. 18:1926–1945. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Tee AR and Blenis J: mTOR, translational control and human disease. Semin Cell Dev Biol. 16:29–37. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Peng T, Golub TR and Sabatini DM: The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol. 22:5575–5584. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A and Hall MN: Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 6:1122–1128. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Cheretakis C, Dror Y and Glogauer M: A noninvasive oral rinse assay to monitor engraftment, neutrophil tissue delivery and susceptibility to infection following HSCT in pediatric patients. Bone Marrow Transplant. 36:227–232. 2005.PubMed/NCBI

12 

Fialkow L, Filho L Fochesatto, Bozzetti MC, Milani AR, Filho EM Rodrigues, Ladniuk RM, Pierozan P, de Moura RM, Prolla JC, Vachon E, et al: Neutrophil apoptosis: A marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome. Crit Care. 10:R1552006. View Article : Google Scholar : PubMed/NCBI

13 

Lin WC, Lin CF, Chen CL, Chen CW and Lin YS: Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury. J Pharmacol Exp Ther. 339:45–53. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Perl M, Hohmann C, Denk S, Kellermann P, Lu D, Braumüller S, Bachem MG, Thomas J, Knöferl MW, Ayala A, et al: Role of activated neutrophils in chest trauma-induced septic acute lung injury. Shock. 38:98–106. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Li C, Liang W, Bi Y, Chen M and Dong S: Protectin D1 promotes resolution of inflammation in a murine model of lipopolysaccharide-induced acute lung injury via enhancing neutrophil apoptosis. Chin Med J (Engl). 127:810–814. 2014.PubMed/NCBI

16 

Shi W, Wei X, Wang Z, Han H, Fu Y, Liu J, Zhang Y, Guo J, Dong C, Zhou D, et al: HDAC9 exacerbates endothelial injury in cerebral ischaemia/reperfusion injury. J Cell Mol Med. 20:1139–1149. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Urbanek T, Kuczmik W, Basta-Kaim A and Gabryel B: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen-glucose deprivation. Brain Res. 1553:1–11. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Lorne E, Zhao X, Zmijewski JW, Liu G, Park YJ, Tsuruta Y and Abraham E: Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol. 41:237–245. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Yen YT, Yang HR, Lo HC, Hsieh YC, Tsai SC, Hong CW and Hsieh CH: Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury. Surgery. 153:689–698. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chen D, Ma T, Liu XW, Yang C and Liu Z: Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFκB activation. Int J Clin Exp Pathol. 8:4627–4638. 2015.PubMed/NCBI

21 

Taneja R, Parodo J, Jia SH, Kapus A, Rotstein OD and Marshall JC: Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med. 32:1460–1469. 2004. View Article : Google Scholar : PubMed/NCBI

22 

O'Neill S, O'Neill AJ, Conroy E, Brady HR, Fitzpatrick JM and Watson RW: Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis. J Leukoc Biol. 68:15–20. 2000.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Zhu C, Yuan Y and Li Z: Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury. Biomed Rep 7: 148-152, 2017.
APA
Li, L., Zhu, C., Yuan, Y., & Li, Z. (2017). Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury. Biomedical Reports, 7, 148-152. https://doi.org/10.3892/br.2017.936
MLA
Li, L., Zhu, C., Yuan, Y., Li, Z."Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury". Biomedical Reports 7.2 (2017): 148-152.
Chicago
Li, L., Zhu, C., Yuan, Y., Li, Z."Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury". Biomedical Reports 7, no. 2 (2017): 148-152. https://doi.org/10.3892/br.2017.936
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Zhu C, Yuan Y and Li Z: Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury. Biomed Rep 7: 148-152, 2017.
APA
Li, L., Zhu, C., Yuan, Y., & Li, Z. (2017). Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury. Biomedical Reports, 7, 148-152. https://doi.org/10.3892/br.2017.936
MLA
Li, L., Zhu, C., Yuan, Y., Li, Z."Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury". Biomedical Reports 7.2 (2017): 148-152.
Chicago
Li, L., Zhu, C., Yuan, Y., Li, Z."Effect of rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury". Biomedical Reports 7, no. 2 (2017): 148-152. https://doi.org/10.3892/br.2017.936
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