Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2017 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes

  • Authors:
    • Bingyan Guo
    • Yongjun Li
    • Xin Jin
    • Suyun Liu
    • Chenglong Miao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
  • Pages: 267-271
    |
    Published online on: July 26, 2017
       https://doi.org/10.3892/br.2017.953
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Endothelin-1 (ET-1) serves an important role in the development of cardiac dysfunction and heart failure. ET‑1 and angiotensin II (AngII) comprise a mutually reciprocal signalling network in the myocardium and serve similar or additive roles in the development of heart failure. Our previous study previously demonstrated that AngII upregulated the expression of APN in cardiomyocytes through an AngII receptor type 2/nitric oxide (NO)/cyclic GMP(cGMP)‑dependent pathway. The purpose of the present study was to determine the effects of ET‑1 and the additive effects of ET‑1 and AngII on the gene expression and secretion of APN, and the underlying mechanisms involved. ELISA was used to determine the secretion of adiponectin (APN) and reverse transcription‑quantitative polymerase chain reaction was used to evaluate the gene expression of APN. ET‑1 induced APN secretion in a time‑ and dose‑dependent manner, and induced APN secretion with AngII simultaneously, as determined via APN mRNA analyses. ETA and ETB receptors were also involved. The use of a NO synthase inhibitor and an analogue of cGMP antagonist resulted in a diminished ET‑1‑ and/or AngII‑mediated APN induction in cardiomyocytes. These results suggested that ET‑1, as well as AngII, upregulated the gene expression and secretion of APN via the common NO/cGMP‑mediated mechanism.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Correa MV, Nolly MB, Caldiz CI, de Cingolani GE, Cingolani HE and Ennis IL: Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1. Pflugers Arch. 466:1819–1830. 2014.PubMed/NCBI

2 

de Jonge HW, Dekkers DH, Houtsmuller AB, Sharma HS and Lamers JM: Differential signaling and hypertrophic responses in cyclically stretched vs endothelin-1 stimulated neonatal rat cardiomyocytes. Cell Biochem Biophys. 47:21–32. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Lin YJ, Kwok CF, Juan CC, Hsu YP, Shih KC, Chen CC and Ho LT: Angiotensin II enhances endothelin-1-induced vasoconstriction through upregulating endothelin type A receptor. Biochem Biophys Res Commun. 451:263–269. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wolf AM, Wolf D, Avila MA, Moschen AR, Berasain C, Enrich B, Rumpold H and Tilg H: Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice. J Hepatol. 44:537–543. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Piñeiro R, Iglesias MJ, Gallego R, Raghay K, Eiras S, Rubio J, Diéguez C, Gualillo O, González-Juanatey JR and Lago F: Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 579:5163–5169. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J, Flyvbjerg A and Hildebrandt P: Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation. 112:1756–1762. 2005. View Article : Google Scholar : PubMed/NCBI

7 

George J, Patal S, Wexler D, Sharabi Y, Peleg E, Kamari Y, Grossman E, Sheps D, Keren G and Roth A: Circulating adiponectin levels predict outcome in patients with severe congestive heart failure. Heart. 92:1420–1424. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Wannamethee SG, Whincup PH, Lennon L and Sattar N: Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure. Arch Intern Med. 167:1510–1517. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Takano H, Obata JE, Kodama Y, Kitta Y, Nakamura T, Mende A, Kawabata K, Saito Y, Fujioka D, Kobayashi T, et al: Adiponectin is released from the heart in patients with heart failure. Int J Cardiol. 132:221–226. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Guo B, Li Y, Han R, Zhou H and Wang M: Angiotensin II upregulation of cardiomyocyte adiponectin production is nitric oxide/cyclic GMP dependent. Am J Med Sci. 341:350–355. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Juan CC, Chuang TY, Chang CL, Huang SW and Ho LT: Endothelin-1 regulates adiponectin gene expression and secretion in 3T3-L1 adipocytes via distinct signaling pathways. Endocrinology. 148:1835–1842. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Bedi D, Clarke KJ, Dennis JC, Zhong Q, Brunson BL, Morrison EE and Judd RL: Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism. Biochem Biophys Res Commun. 345:332–339. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Yin WH, Chen YH, Wei J, Jen HL, Huang WP, Young MS, Chen DC and Liu PL: Associations between endothelin-1 and adiponectin in chronic heart failure. Cardiology. 118:207–216. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Skurk C, Wittchen F, Suckau L, Witt H, Noutsias M, Fechner H, Schultheiss HP and Poller W: Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy. Eur Heart J. 29:1168–1180. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Lau WB, Gao E, Tao L, Yuan Y, Li R, Wang X, Koch WJ and Ma XL: Cardiomyocyte-derived adiponectin is biologically active in protecting against myocardial ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 298:E663–E670. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Kanno K, Hirata Y, Tsujino M, Imai T, Shichiri M, Ito H and Marumo F: Up-regulation of ETB receptor subtype mRNA by angiotensin II in rat cardiomyocytes. Biochem Biophys Res Commun. 194:1282–1287. 1993. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo B, Li Y, Jin X, Liu S and Miao C: Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes. Biomed Rep 7: 267-271, 2017.
APA
Guo, B., Li, Y., Jin, X., Liu, S., & Miao, C. (2017). Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes. Biomedical Reports, 7, 267-271. https://doi.org/10.3892/br.2017.953
MLA
Guo, B., Li, Y., Jin, X., Liu, S., Miao, C."Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes". Biomedical Reports 7.3 (2017): 267-271.
Chicago
Guo, B., Li, Y., Jin, X., Liu, S., Miao, C."Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes". Biomedical Reports 7, no. 3 (2017): 267-271. https://doi.org/10.3892/br.2017.953
Copy and paste a formatted citation
x
Spandidos Publications style
Guo B, Li Y, Jin X, Liu S and Miao C: Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes. Biomed Rep 7: 267-271, 2017.
APA
Guo, B., Li, Y., Jin, X., Liu, S., & Miao, C. (2017). Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes. Biomedical Reports, 7, 267-271. https://doi.org/10.3892/br.2017.953
MLA
Guo, B., Li, Y., Jin, X., Liu, S., Miao, C."Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes". Biomedical Reports 7.3 (2017): 267-271.
Chicago
Guo, B., Li, Y., Jin, X., Liu, S., Miao, C."Nitric oxide/cyclic GMP pathway mediates the endothelin‑1‑upregulation of adiponectin expression in rat cardiomyocytes". Biomedical Reports 7, no. 3 (2017): 267-271. https://doi.org/10.3892/br.2017.953
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team