Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer

  • Authors:
    • Hiromichi Matsuoka
    • Chihiro Makimura
    • Atsuko Koyama
    • Yoshihiko Fujita
    • Junji Tsurutani
    • Kiyohiro Sakai
    • Ryo Sakamoto
    • Kazuto Nishio
    • Kazuhiko Nakagawa
  • View Affiliations / Copyright

    Affiliations: Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osaka 589‑8511, Japan, Department of Genome Biology, Kindai University Faculty of Medicine, Osaka 589‑8511, Japan, Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka 589‑8511, Japan
  • Pages: 380-384
    |
    Published online on: August 8, 2017
       https://doi.org/10.3892/br.2017.963
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Genetic differences in humans cause clinical difficulties in opioid treatment. Previous studies indicate that a single nucleotide polymorphism in the catechol‑O‑methyltransferase (COMT) gene (rs4680; p.Val158Met) may present as a predictive biomarker for the response to morphine treatment. In our previous pilot exploratory study, patients with a G/G genotype were demonstrated to require a higher dose of morphine, compared with patients with A/A and A/G genotypes. In the present study, the aim was to replicate the findings in an independent cohort of opioid‑treatment‑naïve patients exhibiting various types of cancer. This prospective study was conducted from 2011 to 2012 at the Kindai University Faculty of Medicine. A total of 50 patients with opioid‑treatment naïve and histologically confirmed malignant neoplasms who were scheduled to undergo opioid treatment were evaluated in the present study. Assessments were conducted pre‑treatment (day 1), post‑treatment (day 1), and one week after treatment (day 8). The required dose of morphine on day 1 was significantly higher for patients with the G/G genotype of COMT, compared with those with the A/A and A/G genotypes (P=0.013). The results of the present study provide additional evidence that the COMT genotype may be a predictive biomarker for the response to morphine treatment.
View Figures

Figure 1

Figure 2

View References

1 

Cleeland CS: Undertreatment of cancer pain in elderly patients. JAMA. 279:1914–1915. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Patrick DL, Ferketich SL, Frame PS, Harris JJ, Hendricks CB, Levin B, Link MP, Lustig C, McLaughlin J, Reid LD, et al: National Institutes of Health State-of-the-Science Panel: National Institutes of Health State-of-the-Science Conference Statement: Symptom management in cancer: pain, depression, and fatigue. July;15–17. 2002.J Natl Cancer Inst Monogr. 32:9–16, 2004.

3 

Potter J and Higginson IJ: Pain experienced by lung cancer patients: A review of prevalence, causes and pathophysiology. Lung Cancer. 43:247–257. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Butler LD, Koopman C, Cordova MJ, Garlan RW, DiMiceli S and Spiegel D: Psychological distress and pain significantly increase before death in metastatic breast cancer patients. Psychosom Med. 65:416–426. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Bischoff K, Weinberg V and Rabow MW: Palliative and oncologic co-management: Symptom management for outpatients with cancer. Support Care Cancer. 21:3031–3037. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Chase DM, Huang HQ, Wenzel L, Cella D, McQuellon R, Long HJ, Moore DH and Monk BJ: Quality of life and survival in advanced cervical cancer: A Gynecologic Oncology Group study. Gynecol Oncol. 125:315–319. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Kelsen DP, Portenoy RK, Thaler HT, Niedzwiecki D, Passik SD, Tao Y, Banks W, Brennan MF and Foley KM: Pain and depression in patients with newly diagnosed pancreas cancer. J Clin Oncol. 13:748–755. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Turk DC, Sist TC, Okifuji A, Miner MF, Florio G, Harrison P, Massey J, Lema ML and Zevon MA: Adaptation to metastatic cancer pain, regional/local cancer pain and non-cancer pain: Role of psychological and behavioral factors. Pain. 74:247–256. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Lötsch J, Geisslinger G and Tegeder I: Genetic modulation of the pharmacological treatment of pain. Pharmacol Ther. 124:168–184. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Bell GC, Donovan KA and McLeod HL: Clinical implications of opioid pharmacogenomics in patients with cancer. Cancer Control. 22:426–432. 2015.PubMed/NCBI

11 

Rakvåg TT, Klepstad P, Baar C, Kvam TM, Dale O, Kaasa S, Krokan HE and Skorpen F: The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain. 116:73–78. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Rakvåg TT, Ross JR, Sato H, Skorpen F, Kaasa S and Klepstad P: Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Mol Pain. 4:642008. View Article : Google Scholar : PubMed/NCBI

13 

Reyes-Gibby CC, Shete S, Rakvåg T, Bhat SV, Skorpen F, Bruera E, Kaasa S and Klepstad P: Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain. 130:25–30. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Candiotti KA, Yang Z, Buric D, Arheart K, Zhang Y, Rodriguez Y, Gitlin MC, Carvalho E, Jaraba I and Wang L: Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain. Anesth Analg. 119:1194–1200. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Klepstad P, Fladvad T, Skorpen F, Bjordal K, Caraceni A, Dale O, Davies A, Kloke M, Lundström S, Maltoni M, et al: European Association for Palliative Care Research Network: Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients. Pain. 152:1139–1145. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Atkinson TM, Mendoza TR, Sit L, Passik S, Scher HI, Cleeland C and Basch E: The Brief Pain Inventory and its ‘pain at its worst in the last 24 hours’ item: Clinical trial endpoint considerations. Pain Med. 11:337–346. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Matsuoka H, Arao T, Makimura C, Takeda M, Kiyota H, Tsurutani J, Fujita Y, Matsumoto K, Kimura H, Otsuka M, et al: Expression changes in arrestin β 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients. Oncol Rep. 27:1393–1399. 2012.PubMed/NCBI

18 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

19 

Swarm R, Abernethy AP, Anghelescu DL, Benedetti C, Blinderman CD, Boston B, Cleeland C, Coyle N, Deleon-Casasola OA, Eilers JG, et al: NCCN Adult Cancer Pain: Adult cancer pain. J Natl Compr Canc Netw. 8:1046–1086. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Caraceni A, Cherny N, Fainsinger R, Kaasa S, Poulain P, Radbruch L and De Conno F: Pain measurement tools and methods in clinical research in palliative care: Recommendations of an expert working group of the European Association of Palliative Care. J Pain Symptom Manage. 23:239–255. 2002. View Article : Google Scholar : PubMed/NCBI

21 

National Cancer Institute: Common Terminology Criteria for Adverse Events (CTCAE) v4.03, . https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdfJune 14–2010

22 

Montagna P: Recent advances in the pharmacogenomics of pain and headache. Neurol Sci. 28 Suppl 2:S208–S212. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Farrar JT, Polomano RC, Berlin JA and Strom BL: A comparison of change in the 0–10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensity. Anesthesiology. 112:1464–1472. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Tunbridge EM, Harrison PJ and Weinberger DR: Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry. 60:141–151. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS and Goldman D: COMT val158Met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science. 299:1240–1243. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Arnold BS, Alpers GW, Süss H, Friedel E, Kosmützky G, Geier A and Pauli P: Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. Eur J Pain. 12:329–338. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Lee YH, Kim JH and Song GG: Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: A meta-analysis. Rheumatol Int. 35:159–166. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Matsuoka H, Makimura C, Koyama A, Fujita Y, Tsurutani J, Sakai K, Sakamoto R, Nishio K and Nakagawa K: Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer. Biomed Rep 7: 380-384, 2017.
APA
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K. ... Nakagawa, K. (2017). Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer. Biomedical Reports, 7, 380-384. https://doi.org/10.3892/br.2017.963
MLA
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K., Sakamoto, R., Nishio, K., Nakagawa, K."Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer". Biomedical Reports 7.4 (2017): 380-384.
Chicago
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K., Sakamoto, R., Nishio, K., Nakagawa, K."Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer". Biomedical Reports 7, no. 4 (2017): 380-384. https://doi.org/10.3892/br.2017.963
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuoka H, Makimura C, Koyama A, Fujita Y, Tsurutani J, Sakai K, Sakamoto R, Nishio K and Nakagawa K: Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer. Biomed Rep 7: 380-384, 2017.
APA
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K. ... Nakagawa, K. (2017). Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer. Biomedical Reports, 7, 380-384. https://doi.org/10.3892/br.2017.963
MLA
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K., Sakamoto, R., Nishio, K., Nakagawa, K."Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer". Biomedical Reports 7.4 (2017): 380-384.
Chicago
Matsuoka, H., Makimura, C., Koyama, A., Fujita, Y., Tsurutani, J., Sakai, K., Sakamoto, R., Nishio, K., Nakagawa, K."Prospective replication study implicates the catechol-O-methyltransferase Val158Met polymorphism as a biomarker for the response to morphine in patients with cancer". Biomedical Reports 7, no. 4 (2017): 380-384. https://doi.org/10.3892/br.2017.963
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team