Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

  • Authors:
    • Afsaneh Bakhtiari
    • Karimolla Hajian-Tilaki
    • Shabnam Omidvar
    • Fatemeh Nasiri Amiri
  • View Affiliations / Copyright

    Affiliations: Department of Midwifery, Faculty of Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran, Department of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol 47176-47745, Iran
  • Pages: 331-336
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/br.2017.964
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The interconnection between aging and metabolic syndrome (MetS) and their effect on oxidative stress (OxS) status lacks adequate information. Additionally, the age-related changes of antioxidant defenses and OxS in senior women with MetS in comparison to healthy senior women are not yet established. We analyzed the correlation between oxidative defense status and OxS with MetS components. Through further examination of MetS and aging, we aimed to determine their independent effects on OxS and oxidative defense status. This community‑based cross-sectional study was conducted in the rural area of Babol, Iran. A total of 75 women of ≥60 years of age with MetS along with 89 women with similar conditions without the MetS, serving as the control group, were studied. Blood glucose, lipid profile, malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined. Data were analyzed using multiple linear regression, ANOVA and independent t-tests. MDA and TAC levels independently showed a significant correlation with triglyceride (TG), waist circumference, fasting blood glucose and high-density lipoprotein cholesterol (HDL‑C). As suggested by the standardized B (0.810, -0.783, P<0.001; -0.052, P<0.001, 0.047, P<0.01), TG followed by HDL-C were the most strongly correlated factors with MDA and TAC. Furthermore, MetS and age were independent risk factors for antioxidant activity reduction and OxS. However, MetS had a much higher predictive power than age (standardized B 0.573 for MetS and 0.376 for age, P<0.001). Aging and MetS, both lead to OxS, but the impact of MetS on this disorder was far greater than the effect of age. However, their cumulative effects can lead to a worsening of the situation. Therefore, early diagnosis and treatment of MetS, especially in the elderly can prevent any adverse impact of MetS.
View Figures
View References

1 

Manda-Handzlik A and Demkow U: Neutrophils: The role of oxidative and nitrosative stress in health and disease. Adv Exp Med Biol. 857:51–60. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ho E, Karimi Galougahi K, Liu CC, Bhindi R and Figtree GA: Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol. 1:483–491. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Jansen EH and Ruskovska T: Comparative analysis of serum (anti)oxidative status parаmeters in healthy persons. Int J Mol Sci. 14:6106–6115. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Francisqueti FV, Chiaverini LC, Santos KC, Minatel IO, Ronchi CB, Ferron AJ, Ferreira AL and Corrêa CR: The role of oxidative stress on the pathophysiology of metabolic syndrome. Rev Assoc Med Bras (1992). 63:85–91. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Tiganis T: Reactive oxygen species and insulin resistance: The good, the bad and the ugly. Trends Pharmacol Sci. 32:82–89. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Romano AD, Serviddio G, de Matthaeis A, Bellanti F and Vendemiale G: Oxidative stress and aging. J Nephrol. 23 Suppl 15:S29–S36. 2010.PubMed/NCBI

7 

Ziaei S, Sayahi M and Faghihzadeh S: Relationship between reproductive aging, body composition, hormonal status and metabolic syndrome in postmenopausal women. Climacteric. 14:649–653. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ganjifrockwala F, Joseph J and George G: Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients. JEMDSA. 22:21–25. 2017.

9 

Delavar R, Mogharnasi M and Khoobkhahi N: The effects of combined training on oxidative stress and antioxidant defense indicators. Int J Basic Sci Med. 2:V29–V32. 2017. View Article : Google Scholar

10 

Inglés M, Gambini J, Carnicero JA, García-García FJ, Rodríguez-Mañas L, Olaso-González G, Dromant M, Borrás C and Viña J: Oxidative stress is related to frailty, not to age or sex, in a geriatric population: Lipid and protein oxidation as biomarkers of frailty. J Am Geriatr Soc. 62:1324–1328. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Hajian-Tilaki K: Metabolic syndrome and its associated risk factors in Iranian adults. Caspian J Intern Med. 6:51–61. 2015.PubMed/NCBI

12 

Hajian-Tilaki K, Heidari B, Firouzjahi A, Bagherzadeh M, Hajian-Tilaki A and Halalkhor S: Prevalence of metabolic syndrome and the association with socio-demographic characteristics and physical activity in urban population of Iranian adults: A population-based study. Diabetes Metab Syndr. 8:170–176. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Adib-Hajbaghery M and Aghahoseini S: The evaluation of disability and its related factors among the elderly population in Kashan, Iran. BMC Public Health. 7:2612007. View Article : Google Scholar : PubMed/NCBI

14 

Taslim S and Tai ES: The relevance of the metabolic syndrome. Ann Acad Med Singapore. 38:29–35. 2009.PubMed/NCBI

15 

Ruiz-Ramos M, Vargas LA, Van der Goes Fortoul TI, Cervantes-Sandoval A and Mendoza-Nunez VM: Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J Nutr Health Aging. 14:467–472. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Cerniauskiene LR, Luksiene DI, Tamosiūnas A, Reklaitiene R and Margeviciene L: Association of metabolic syndrome and oxidative stress with ischemic heart disease in middle-aged persons. Medicina (Kaunas). 44:392–399. 2008.(In Lithuanian). PubMed/NCBI

17 

Benzie IF and Strain JJ: The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: The FRAP assay. Anal Biochem. 239:70–76. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Maugeri D, Santangelo A, Bonanno MR, Testai M, Abbate S, Lo Giudice F, Mamazza C, Pugllsi N and Panebianco P: Oxidative stress and aging: Studies on an east-sicilian, ultraoctagenarian population living in institutes or at home. Arch Gerontol Geriatr Suppl. 38:271–277. 2004. View Article : Google Scholar

19 

Bitla AR, Kumari NM, Reddy NS, Nagaraju KV, Sachan A, Kumar VP, Suchitra MM and Rao Srinivasa PVLN: Antioxidant status in patients with metabolic syndrome as measured by ferric reducing ability of plasma (FRAP) assay. J Clin Sci Res. 3:114–120. 2012.

20 

Carrier A: Metabolic syndrome and oxidative stress: A complex relationship. Antioxidants & Redox Signaling. 26:429–431. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Picu A, Petcu L, Ştefan S, Mitu M, Lixandru D, Ionescu-Tîrgovişte C, Pîrcălăbioru GG, Ciulu-Costinescu F, Bubulica MV and Chifiriuc MC: Markers of oxidative stress and antioxidant defense in romanian patients with Type 2 diabetes mellitus and obesity. Molecules. 22:E7142017. View Article : Google Scholar : PubMed/NCBI

22 

Abdilla N, Tormo MC, Fabia MJ, Chaves FJ, Saez G and Redon J: Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension. J Hum Hypertens. 21:68–75. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Løhr M, Jensen A, Eriksen L, Grønbæk M, Loft S and Møller P: Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells. Oncotarget. 6:2641–2653. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Najarzadeh A, Mozaffari-Khosravi H, Mahdavi M, Fallahzadeh H, Zavar-Reza J and Shahmoradi H: Antioxidant status in patients with metabolic syndrome as measured by the stable free radical diphenylpicrylhydrazyl assay. IJDO. 4:161–166. 2012.

25 

Pihl E, Zilmer K, Kullisaar T, Kairane C, Pulges A and Zilmer M: High-sensitive C-reactive protein level and oxidative stress-related status in former athletes in relation to traditional cardiovascular risk factors. Atherosclerosis. 171:321–326. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Kural Vanizor B, Orem A, Cimsit G, Yandi YE and Calapoglu M: Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant-antioxidant system in patients with psoriasis. Clin Chim Acta. 328:971–982. 2003.

27 

Dalvand S, Niksima SH, Meshkani R, Gheshlagh Ghanei R, Sadegh-Nejadi S, Kooti W, Parizad N, Zahednezhad H and Afrisham R: Prevalence of metabolic syndrome among iranian population: A systematic review and meta-analysis. Iran J Public Health. 46:456–467. 2017.PubMed/NCBI

28 

Guarner-Lans V, Rubio-Ruiz ME, Pérez-Torres I and de MacCarthy Baños G: Relation of aging and sex hormones to metabolic syndrome and cardiovascular disease. Exp Gerontol. 46:517–523. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Bonomini F, Rodella LF and Rezzani R: Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis. 6:109–120. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Guarner-Lans V and Rubio-Ruiz ME: Aging, metabolic syndrome and the heart. Aging Dis. 3:269–279. 2012.PubMed/NCBI

31 

Myung SK, Ju W, Cho B, Oh SW, Park SM, Koo BK and Park BJ: Korean meta-analysis study group: Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: Systematic review and meta-analysis of randomised controlled trials. BMJ. 346:f102013. View Article : Google Scholar : PubMed/NCBI

32 

Ye Y, Li J and Yuan Z: Effect of antioxidant vitamin supplementation on cardiovascular outcomes: A meta-analysis of randomized controlled tri https. PloS One. 8:e568032012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bakhtiari A, Hajian-Tilaki K, Omidvar S and Nasiri Amiri F : Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women. Biomed Rep 7: 331-336, 2017.
APA
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., & Nasiri Amiri, F. . (2017). Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women. Biomedical Reports, 7, 331-336. https://doi.org/10.3892/br.2017.964
MLA
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., Nasiri Amiri, F. ."Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women". Biomedical Reports 7.4 (2017): 331-336.
Chicago
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., Nasiri Amiri, F. ."Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women". Biomedical Reports 7, no. 4 (2017): 331-336. https://doi.org/10.3892/br.2017.964
Copy and paste a formatted citation
x
Spandidos Publications style
Bakhtiari A, Hajian-Tilaki K, Omidvar S and Nasiri Amiri F : Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women. Biomed Rep 7: 331-336, 2017.
APA
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., & Nasiri Amiri, F. . (2017). Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women. Biomedical Reports, 7, 331-336. https://doi.org/10.3892/br.2017.964
MLA
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., Nasiri Amiri, F. ."Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women". Biomedical Reports 7.4 (2017): 331-336.
Chicago
Bakhtiari, A., Hajian-Tilaki, K., Omidvar, S., Nasiri Amiri, F. ."Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women". Biomedical Reports 7, no. 4 (2017): 331-336. https://doi.org/10.3892/br.2017.964
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team