Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The role of hyperuricemia on vascular endothelium dysfunction

  • Authors:
    • Haitao Zhen
    • Fen Gui
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, School of Medicine, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Xianning Central Hospital, Xianning, Hubei 437100, P.R. China
  • Pages: 325-330
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/br.2017.966
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hyperuricemia appears to be associated with an increased risk for cardiovascular disease and associated mortality. Population epidemiological data support a causal link between hyperuricemia and cardiovascular disease. Endothelium injury could be one of the potential mechanisms in hyperuricemia‑induced cardiovascular disease. However, the specific role of uric acid (UA) in the impairment of vascular relaxation and its signal transduction pathway has not been examined. The authors investigated the role of UA on vascular relaxation, nitric oxide (NO) production and expression of proinflammatory cytokines. Brachial flow‑mediated dilation and nitroglycerine‑mediated dilation were measured by B‑mode ultrasound with 10 megahertz linear‑array transducer from 21 patients with hyperuricemia and 16 control subjects. Human umbilical vein endothelial cells (ECs) were incubated with UA (5‑15 mg/dl) with or without nuclear factor (NF)‑κB inhibitor II. Hyperuricemia inhibited brachial flow‑mediated dilation. While UA significantly inhibited NO expression with time course‑ and dose‑ dependent manner in the cultured ECs, 10 mg/dl UA also increased expression of inflammation cytokine interleukin (IL)‑6, IL‑8 and tumor necrosis factor‑α in vitro. These abnormalities were associated with UA‑induced activation of transcription factor NF‑κB. Furthermore, NF‑κB inhibitor II prevented UA-induced reduction of NO and increased inflammation cytokines. These data suggested hyperuricemia‑induced endothelium injury and vascular dysfunction by a reduction of NO and expression of inflammatory cytokines through the NF-κB pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Mallat SG, Al Kattar S, Tanios BY and Jurjus A: Hyperuricemia, Hypertension, and Chronic Kidney Disease: An Emerging Association. Curr Hypertens Rep. 18:742016. View Article : Google Scholar : PubMed/NCBI

2 

Essex MN, Hopps M, Bienen EJ, Udall M, Mardekian J and Makinson GT: Evaluation of the relationship between serum uric acid levels and cardiovascular events in patients with gout: A retrospective analysis using electronic medical record data. J Clin Rheumatol. 23:160–166. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Bos MJ, Koudstaal PJ, Hofman A, Witteman JC and Breteler MM: Uric acid is a risk factor for myocardial infarction and stroke: The Rotterdam study. Stroke. 37:1503–1507. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Fang J and Alderman MH: Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA. 283:2404–2410. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Ford ES, Li C, Cook S and Choi HK: Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation. 115:2526–2532. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Lehto S, Niskanen L, Rönnemaa T and Laakso M: Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke. 29:635–639. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Li P, Zhang L, Zhang M, Zhou C and Lin N: Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: A mechanism for uric acid-induced endothelial dysfunction. Int J Mol Med. 37:989–997. 2016.PubMed/NCBI

8 

Cai W, Duan XM, Liu Y, Yu J, Tang YL, Liu ZL, Jiang S, Zhang CP, Liu JY and Xu JX: Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway. BioMed Res Int. 2017:43919202017. View Article : Google Scholar : PubMed/NCBI

9 

Wong CK, Chen Y, Ho LM, Zhen Z, Siu CW, Tse HF and Yiu KH: The effects of hyperuricaemia on flow-mediated and nitroglycerin-mediated dilatation in high-risk patients. Nutr Metab Cardiovasc Dis. 24:1012–1019. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Naka KK, Papathanassiou K, Bechlioulis A, Kazakos N, Pappas K, Tigas S, Makriyiannis D, Tsatsoulis A and Michalis LK: Determinants of vascular function in patients with type 2 diabetes. Cardiovasc Diabetol. 11:1272012. View Article : Google Scholar : PubMed/NCBI

11 

Calvert JW: Cardioprotective effects of nitrite during exercise. Cardiovasc Res. 89:499–506. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Wang R, Zhang Y, Xu L, Lin Y, Yang X, Bai L, Chen Y, Zhao S, Fan J, Cheng X, et al: Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice. Sci Rep. 6:367902016. View Article : Google Scholar : PubMed/NCBI

13 

Slanina H, Schmutzler M, Christodoulides M, Kim KS and Schubert-Unkmeir A: Effective plasmid DNA and small interfering RNA delivery to diseased human brain microvascular endothelial cells. J Mol Microbiol Biotechnol. 22:245–257. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhang D, Atlasi SS, Patel KK, Zhuang Z and Heaney AP: False responses of Renilla luciferase reporter control to nuclear receptor TR4. Mol Cell Biochem. 430:139–147. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ding XH, Wang X, Cao R, Yang X, Xiao W, Zhang Y, Bai Y, Wu H and Ye P: A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study. Medicine (Baltimore). 96:e59572017. View Article : Google Scholar : PubMed/NCBI

16 

Volterrani M, Iellamo F, Sposato B and Romeo F: Uric acid lowering therapy in cardiovascular diseases. Int J Cardiol. 213:20–22. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Huang J, Sun Y, Niu K, Wan Z, Yao W, Gao Y, Zhang W, Li Y, Zhao H and Wu X: Does elevated serum uric acid level predict the hypertension incidence? A Chinese prospective cohort study. Clin Exp Hypertens. 37:498–504. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Yang TY, Fang CY, Chen JS, Po HL, Chou LP, Chiang CY and Ueng KC: Association of Serum Uric Acid with Cardiovascular Disease in Taiwanese Patients with Primary Hypertension. Acta Cardiol Sin. 31:42–51. 2015.PubMed/NCBI

19 

McCarthy CG, Goulopoulou S, Wenceslau CF, Spitler K, Matsumoto T and Webb RC: Toll-like receptors and damage-associated molecular patterns: Novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol. 306:H184–H196. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Verdoia M, Barbieri L, Schaffer A, Cassetti E, Nardin M, Bellomo G, Aimaretti G, Marino P, Sinigaglia F and De Luca G: Novara Atherosclerosis Study Group (NAS): Impact of diabetes on uric acid and its relationship with the extent of coronary artery disease and platelet aggregation: A single-centre cohort study. Metabolism. 63:640–646. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Borghi C and Desideri G: Urate-lowering drugs and prevention of cardiovascular disease: The emerging role of xanthine oxidase inhibition. Hypertension. 67:496–498. 2016.PubMed/NCBI

22 

Kaneko C, Ogura J, Sasaki S, Okamoto K, Kobayashi M, Kuwayama K, Narumi K and Iseki K: Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation. Biochim Biophys Acta. 1861:559–566. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Spiga R, Marini MA, Mancuso E, Di Fatta C, Fuoco A, Perticone F, Andreozzi F, Mannino GC and Sesti G: Uric acid is associated with inflammatory biomarkers and induces inflammation via activating the NF-κB Signaling Pathway in HepG2 Cells. Arterioscler Thromb Vasc Biol. 37:1241–1249. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Luo C, Lian X, Hong L, Zou J, Li Z, Zhu Y, Huang T, Zhang Y, Hu Y, Yuan H, et al: High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1. Cell Physiol Biochem. 40:538–548. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Lee KS, Kim J, Kwak SN, Lee KS, Lee DK, Ha KS, Won MH, Jeoung D, Lee H, Kwon YG, et al: Functional role of NF-κB in expression of human endothelial nitric oxide synthase. Biochem Biophys Res Commun. 448:101–107. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Grumbach IM, Chen W, Mertens SA and Harrison DG: A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription. J Mol Cell Cardiol. 39:595–603. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhen H and Gui F: The role of hyperuricemia on vascular endothelium dysfunction. Biomed Rep 7: 325-330, 2017.
APA
Zhen, H., & Gui, F. (2017). The role of hyperuricemia on vascular endothelium dysfunction. Biomedical Reports, 7, 325-330. https://doi.org/10.3892/br.2017.966
MLA
Zhen, H., Gui, F."The role of hyperuricemia on vascular endothelium dysfunction". Biomedical Reports 7.4 (2017): 325-330.
Chicago
Zhen, H., Gui, F."The role of hyperuricemia on vascular endothelium dysfunction". Biomedical Reports 7, no. 4 (2017): 325-330. https://doi.org/10.3892/br.2017.966
Copy and paste a formatted citation
x
Spandidos Publications style
Zhen H and Gui F: The role of hyperuricemia on vascular endothelium dysfunction. Biomed Rep 7: 325-330, 2017.
APA
Zhen, H., & Gui, F. (2017). The role of hyperuricemia on vascular endothelium dysfunction. Biomedical Reports, 7, 325-330. https://doi.org/10.3892/br.2017.966
MLA
Zhen, H., Gui, F."The role of hyperuricemia on vascular endothelium dysfunction". Biomedical Reports 7.4 (2017): 325-330.
Chicago
Zhen, H., Gui, F."The role of hyperuricemia on vascular endothelium dysfunction". Biomedical Reports 7, no. 4 (2017): 325-330. https://doi.org/10.3892/br.2017.966
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team