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Case Report

A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report

  • Authors:
    • Muhammad Asif
    • Abrar Hussain
    • Abdul Wali
    • Nazeer Ahmad
    • Naheed Sajjad
    • Muhammad Amir
    • Irfan Ali
    • Peter Natesan Pushparaj
    • Mahmood Rasool
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan, Department of Biotechnology, Sardar Bahadur Khan Women's University, Quetta 87500, Pakistan, Akhuwat Faisalabad Institute of Research Science and Technology, Faisalabad 38000, Pakistan, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
  • Pages: 377-379
    |
    Published online on: August 17, 2017
       https://doi.org/10.3892/br.2017.967
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Abstract

Philadelphia (Ph)-positive chromosome or Ph translocation has been recognized in 90-95 chronic myeloid leukemia (CML) cases worldwide. However, only 5-8% CML patients show complex variant translocations. In the present study, hematological tests for a 47-year-old female CML patient were performed to determine the hemoglobin, platelets and total leukocyte values. A FISH test was carried out to recognize the BCR/ABL gene fusion, and a cytogenetic analysis was performed. The hematological results showed an increase in WBC (414000/mm3) and a decrease in hemoglobin (8.9 mg/dl), indicating the anemic condition in the CML patient. Furthermore, cytogenetic karyotyping results showed 46,XX,t(6;9;22)(p21;q34;q11) and positive for Ph chromosome. In conclusion, in the present study, we report a rare three-way complex variant translocation in a CML patient.
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Copy and paste a formatted citation
Spandidos Publications style
Asif M, Hussain A, Wali A, Ahmad N, Sajjad N, Amir M, Ali I, Pushparaj PN and Rasool M: A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomed Rep 7: 377-379, 2017.
APA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M. ... Rasool, M. (2017). A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomedical Reports, 7, 377-379. https://doi.org/10.3892/br.2017.967
MLA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7.4 (2017): 377-379.
Chicago
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7, no. 4 (2017): 377-379. https://doi.org/10.3892/br.2017.967
Copy and paste a formatted citation
x
Spandidos Publications style
Asif M, Hussain A, Wali A, Ahmad N, Sajjad N, Amir M, Ali I, Pushparaj PN and Rasool M: A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomed Rep 7: 377-379, 2017.
APA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M. ... Rasool, M. (2017). A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report. Biomedical Reports, 7, 377-379. https://doi.org/10.3892/br.2017.967
MLA
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7.4 (2017): 377-379.
Chicago
Asif, M., Hussain, A., Wali, A., Ahmad, N., Sajjad, N., Amir, M., Ali, I., Pushparaj, P. N., Rasool, M."A rare case of three-way complex variant translocation in chronic myeloid leukemia t(6;9;22)(p21;q34;q11): A case report". Biomedical Reports 7, no. 4 (2017): 377-379. https://doi.org/10.3892/br.2017.967
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