Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Exercise improves high fat diet-impaired vascular function

  • Authors:
    • Jun Fang
    • Mei Tang
  • View Affiliations / Copyright

    Affiliations: Division of Nephrology, Department of Internal Medicine, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Infusion Preparation Center of the Pharmacy Department, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
  • Pages: 337-342
    |
    Published online on: August 25, 2017
       https://doi.org/10.3892/br.2017.972
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prevalence of metabolic syndrome and cardiovascular disease is increasing due to increases in the consumption of high fat diets (HFDs) and the epidemic of obesity. In the present study, it was hypothesized that swimming exercise may prevent HFD-induced impairment of aortic function and that these changes are associated with reduction of oxidative stress, proinflammatory adipokines/cytokines. Male, 6-week-old C57BL/6J mice were fed a 60% lipid composition HFD with or without swimming exercise (90 min/swim and 2 swims/day) for 16 weeks. Exercise training prevented HFD-induced increases in visceral fat weight, total cholesterol and triglycerides. Furthermore, exercise training improved HFD-impaired aortic endothelium-dependent dilation that was associated with reduction of oxidative stress, leptin, resistin, monocyte chemoattractant protein 1, interleukin (IL)6 and IL8. In addition, exercise inhibited HFD-induced vascular endothelial growth factor expression in gastrocnemius skeletal muscle. These data demonstrate that swimming exercise prevents aortic tissue oxidative stress, inflammation and vascular dysfunction in HFD-induced obesity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ramalho L, da Jornada MN, Antunes LC and Hidalgo MP: Metabolic disturbances due to a high-fat diet in a non-insulin-resistant animal model. Nutr Diabetes. 7:e2452017. View Article : Google Scholar : PubMed/NCBI

2 

Huang S, Liu H, Meng N, Li B and Wang J: Hypolipidemic and Antioxidant effects of Malus toringoides (Rehd.) hughes leaves in high-fat-diet-induced hyperlipidemic rats. J Med Food. 20:258–264. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Lim S and Meigs JB: Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol. 34:1820–1826. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Townsend RR: Arterial stiffness: Recommendations and Standardization. Pulse Basel. 4 Suppl 1:3–7. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H and Yamaguchi Y: Chemokine profiles of human visceral adipocytes from cryopreserved preadipocytes: Neutrophil activation and induction of nuclear factor-kappa B repressing factor. Life Sci. 143:225–230. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Selcuk A, Bulucu F, Kalafat F, Cakar M, Demirbas S, Karaman M, Ay SA, Saglam K, Balta S, Demirkol S, et al: Skinfold thickness as a predictor of arterial stiffness: Obesity and fatness linked to higher stiffness measurements in hypertensive patients. Clin Exp Hypertens. 35:459–464. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD and Riehle C: Exercise training improves vascular mitochondrial function. Am J Physiol Heart Circ Physiol. 310:H821–H829. 2016.PubMed/NCBI

8 

Morishima T, Restaino RM, Walsh LK, Kanaley JA, Fadel PJ and Padilla J: Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol. 311:H177–H182. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Li YY, Shi ZM, Yu XY, Feng P and Wang XJ: Urotensin II-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells. World J Gastroenterol. 22:5769–5779. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yan Q, Liu Q, Zweier JL and Liu X: Potency of authentic nitric oxide in inducing aortic relaxation. Pharmacol Res. 55:329–334. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Tang M and Fang J: TNF-α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Mol Med Rep. 15:1407–1411. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Zhang FL, Xing YQ, Wu YH, Liu HY, Luo Y, Sun MS, Guo ZN and Yang Y: The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: A population-based cross-sectional survey. Lipids Health Dis. 16:612017. View Article : Google Scholar : PubMed/NCBI

13 

Raj M: Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab. 16:13–19. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Yamashita T, Kawashima S, Ohashi Y, Ozaki M, Rikitake Y, Inoue N, Hirata K, Akita H and Yokoyama M: Mechanisms of reduced nitric oxide/cGMP-mediated vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. Hypertension. 36:97–102. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Rodriguez-Pascual F, Miras-Portugal MT and Torres M: Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: Inhibitory role mediated by cyclic GMP-dependent protein kinase. Mol Pharmacol. 49:1058–1070. 1996.PubMed/NCBI

16 

Rios FJ, Neves KB, Nguyen Dinh Cat A, Even S, Palacios R, Montezano AC and Touyz RM: Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 353:27–34. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA and Benjamin EJ: Framingham Study: Obesity and systemic oxidative stress: Clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 23:434–439. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Csányi G and Miller FJ Jr: Oxidative stress in cardiovascular disease. Int J Mol Sci. 15:6002–6008. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Rocha M, Apostolova N, Hernandez-Mijares A, Herance R and Victor VM: Oxidative stress and endothelial dysfunction in cardiovascular disease: Mitochondria-targeted therapeutics. Curr Med Chem. 17:3827–3841. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Lozano I, Van der Werf R, Bietiger W, Seyfritz E, Peronet C, Pinget M, Jeandidier N, Maillard E, Marchioni E, Sigrist S, et al: High-fructose and high-fat diet-induced disorders in rats: Impact on diabetes risk, hepatic and vascular complications. Nutr Metab (Lond). 13:152016. View Article : Google Scholar : PubMed/NCBI

21 

Guo X, Li J, Tang R, Zhang G, Zeng H, Wood RJ and Liu Z: High fat diet alters gut microbiota and the expression of paneth cell-antimicrobial peptides preceding changes of circulating inflammatory cytokines. Mediators Inflamm. 2017:94748962017. View Article : Google Scholar : PubMed/NCBI

22 

Wong A, Sanchez-Gonzalez M, Kalfon R, Alvarez-Alvarado S and Figueroa A: The effects of stretching training on cardiac autonomic function in obese postmenopausal women. Altern Ther Health Med. 23:20–26. 2017.PubMed/NCBI

23 

Toyama K, Sugiyama S, Oka H, Hamada M, Iwasaki Y, Horio E, Rokutanda T, Nakamura S, Spin JM, Tsao PS, et al: A pilot study: The beneficial effects of combined statin-exercise therapy on cognitive function in patients with coronary artery disease and mild cognitive decline. Intern Med. 56:641–649. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Onat A: Metabolic syndrome: Nature, therapeutic solutions and options. Expert Opin Pharmacother. 12:1887–1900. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Szostak J and Laurant P: The forgotten face of regular physical exercise: A ‘natural’ anti-atherogenic activity. Clin Sci (Lond). 121:91–106. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Peeri M and Amiri S: Protective effects of exercise in metabolic disorders are mediated by inhibition of mitochondrial-derived sterile inflammation. Med Hypotheses. 85:707–709. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Silvennoinen M, Rinnankoski-Tuikka R, Vuento M, Hulmi JJ, Torvinen S, Lehti M, Kivelä R and Kainulainen H: High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries. Angiogenesis. 16:297–307. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fang J and Tang M: Exercise improves high fat diet-impaired vascular function. Biomed Rep 7: 337-342, 2017.
APA
Fang, J., & Tang, M. (2017). Exercise improves high fat diet-impaired vascular function. Biomedical Reports, 7, 337-342. https://doi.org/10.3892/br.2017.972
MLA
Fang, J., Tang, M."Exercise improves high fat diet-impaired vascular function". Biomedical Reports 7.4 (2017): 337-342.
Chicago
Fang, J., Tang, M."Exercise improves high fat diet-impaired vascular function". Biomedical Reports 7, no. 4 (2017): 337-342. https://doi.org/10.3892/br.2017.972
Copy and paste a formatted citation
x
Spandidos Publications style
Fang J and Tang M: Exercise improves high fat diet-impaired vascular function. Biomed Rep 7: 337-342, 2017.
APA
Fang, J., & Tang, M. (2017). Exercise improves high fat diet-impaired vascular function. Biomedical Reports, 7, 337-342. https://doi.org/10.3892/br.2017.972
MLA
Fang, J., Tang, M."Exercise improves high fat diet-impaired vascular function". Biomedical Reports 7.4 (2017): 337-342.
Chicago
Fang, J., Tang, M."Exercise improves high fat diet-impaired vascular function". Biomedical Reports 7, no. 4 (2017): 337-342. https://doi.org/10.3892/br.2017.972
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team