Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
December-2017 Volume 7 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 7 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population

  • Authors:
    • Serdal Arslan
    • Öcal Berkan
    • Burcu Bayyurt
    • Osman Beton
    • Ni̇l Özbi̇lüm Şahin
    • Eylem Itır Aydemir
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey, Department of Cardiovascular Surgery, Heart Center, Cumhuriyet University, 58140 Sivas, Turkey, Department of Cardiology, Heart Center, Cumhuriyet University, 58140 Sivas, Turkey, Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey, Department of Statistics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey
  • Pages: 547-552
    |
    Published online on: October 3, 2017
       https://doi.org/10.3892/br.2017.995
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Myeloperoxidase (MPO) is an oxidative hemoprotein compound expressed in polymorphonuclear leukocytes that contributes to inflammatory responses. Coronary artery disease (CAD), as the most prevalent form of heart disease, is considered to originate from an interaction between genetic and environmental factors. In the present study, the potential associations between MPO‑463G/A and ‑129G/A polymorphisms with CAD were investigated in a Turkish population using a polymerase chain reaction‑based restriction fragment length polymorphism (RFLP) assay technique. To the best of our knowledge, the study was the first to examine the association of MPO‑463G/A and ‑129G/A with patient survival rate in a Turkish population. The study population consisted of 201 patients with CAD and 201 healthy controls. The results indicated that there was a significant association of the GA genotype of MPO‑463G/A with the case population (P=0.048). Meanwhile, in the patients with CAD, the frequency distributions of the MPO‑129A allele (P=0.006) and GA genotype (P=0.001) were significantly increased compared with the G allele and GG genotype, respectively, in CAD patients. Additionally, compared with the GG genotype, the frequency distribution of MPO‑129A was significantly increased in the patient group regarding smoking status (P=0.001) and the presence of hypercholesterolemia (P=0.028). However, survival analysis did not detect an effect of either polymorphism on the survival rate of the CAD patients (P>0.05). Therefore, the MPO‑129GA genotype may be a significant risk factor for the development of CAD.
View Figures
View References

1 

Grimes DS: An epidemic of coronary heart disease. QJM. 105:509–518. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352:1685–1695. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, et al: From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 108:1664–1672. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Roman RM, Wendland AE and Polanczyk CA: Myeloperoxidase and coronary arterial disease: From research to clinical practice. Arq Bras Cardiol. 91:e11–e19. 2008.PubMed/NCBI

5 

Morishita K, Tsuchiya M, Asano S, Kaziro Y and Nagata S: Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. J Biol Chem. 262:15208–15213. 1987.PubMed/NCBI

6 

Piedrafita FJ, Molander RB, Vansant G, Orlova EA, Pfahl M and Reynolds WF: An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element. J Biol Chem. 271:14412–14420. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Pecoits-Filho R, Stenvinkel P, Marchlewska A, Heimburger O, Bárány P, Hoff CM, Holmes CJ, Suliman M, Lindholm B, Schalling M and Nordfors L: A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Kidney Int Suppl. 84:S172–S176. 2003. View Article : Google Scholar

8 

Davies MJ, Hawkins CL, Pattison DI and Rees MD: Mammalian heme peroxidases: From molecular mechanisms to health implications. Antioxid Redox Signal. 10:1199–1234. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Hampton MB, Kettle AJ and Winterbourn CC: Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing. Blood. 92:3007–3017. 1998.PubMed/NCBI

10 

Verdecchia P, Angeli F, Cavallini C, Mazzotta G, Garofoli M, Martire P and Reboldi G: The optimal blood pressure target for patients with coronary artery disease. Curr Cardiol Rep. 12:302–306. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Cannon CP and Vierck E: The New Heart Disease Handbook. 1st edition. Fair Winds Press; Beverly, MA: 2009

12 

Sambrook J, Fritsch EF and Maniatis T: Molecular Cloning - A Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory Press; Cold Spring Harbor, NY: 1989

13 

Arslan S, Pinarbasi H and Silig Y: Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population. Mol Med Rep. 4:87–92. 2011.PubMed/NCBI

14 

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2095–2128. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Lusis AJ, Mar R and Pajukanta P: Genetics of atherosclerosis. Annu Rev Genomics Hum Genet. 5:189–218. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Steinberg D and Witztum JL: Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 105:2107–2111. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Hillegass LM, Griswold DE, Brickson B and Albrightson-Winslow C: Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods. 24:285–295. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Nikpoor B, Turecki G, Fournier C, Théroux P and Rouleau GA: A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians. Am Heart J. 142:336–339. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Zotova E, Lyrenäs L, de Faire U, Morgenstern R, Gigante B and Bennet AM: The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: Protective role of the −129A allele in women. Coron Artery Dis. 20:322–326. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Ergen A, İsbir S, Timirci Ö, Tekeli A and İsbir T: Effects of myeloperoxidase −463 G/A gene polymorphism and plasma levels on coronary artery disease. Mol Biol Rep. 38:887–891. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Tang N, Wang Y and Mei Q: Myeloperoxidase G-463A polymorphism and susceptibility to coronary artery disease: A meta-analysis. Gene. 523:152–157. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Borges FK, Borges FK, Stella SF, Souza JF, Wendland AE, Werres Junior LC, Ribeiro JP and Polanczyk CA: Serial analyses of C-reactive protein and myeloperoxidase in acute coronary syndrome. Clin Cardiol. 32:E58–E62. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Nicholls SJ and Hazen SL: Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol. 25:1102–1111. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Puddu P, Cravero E, Puddu GM and Muscari A: Genes and atherosclerosis: At the origin of the predisposition. Int J Clin Pract. 59:462–472. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Mocatta TJ, Pilbrow AP, Cameron VA, Senthilmohan R, Frampton CM, Richards AM and Winterbourn CC: Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. J Am Coll Cardiol. 49:1993–2000. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Meuwese MC, Stroes ES, Hazen SL, van Miert JN, Kuivenhoven JA, Schaub RG, Wareham NJ, Luben R, Kastelein JJ, Khaw KT and Boekholdt SM: Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: The EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol. 50:159–165. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Finegold JA, Asaria P and Francis DP: Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations. Int J Cardiol. 168:934–945. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Maddhuri S, Pallapolu P, Bandaru S, Suresh G, Malempati AR, Jyothy A and Mundluru HP: Analysis of plasma myeloperoxidase levels and functional gene −463G>A and −129G>A polymorphisms with early onset of coronary artery disease in South Indian population. Folia Cardiol. 11:272–278. 2016. View Article : Google Scholar

29 

Li YY, Wang H, Qian J, Kim HJ, Wu JJ, Wang LS, Zhou CW, Yang ZJ and Lu XZ: PRISMA-combined Myeloperoxidase −463G/A gene polymorphism and coronary artery disease: A meta-analysis of 4744 subjects. Medicine (Baltimore). 96:e64612017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Arslan S, Berkan Ö, Bayyurt B, Beton O, Şahin NÖ and Aydemir EI: Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population. Biomed Rep 7: 547-552, 2017.
APA
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N.Ö., & Aydemir, E.I. (2017). Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population. Biomedical Reports, 7, 547-552. https://doi.org/10.3892/br.2017.995
MLA
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N. Ö., Aydemir, E. I."Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population". Biomedical Reports 7.6 (2017): 547-552.
Chicago
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N. Ö., Aydemir, E. I."Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population". Biomedical Reports 7, no. 6 (2017): 547-552. https://doi.org/10.3892/br.2017.995
Copy and paste a formatted citation
x
Spandidos Publications style
Arslan S, Berkan Ö, Bayyurt B, Beton O, Şahin NÖ and Aydemir EI: Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population. Biomed Rep 7: 547-552, 2017.
APA
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N.Ö., & Aydemir, E.I. (2017). Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population. Biomedical Reports, 7, 547-552. https://doi.org/10.3892/br.2017.995
MLA
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N. Ö., Aydemir, E. I."Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population". Biomedical Reports 7.6 (2017): 547-552.
Chicago
Arslan, S., Berkan, Ö., Bayyurt, B., Beton, O., Şahin, N. Ö., Aydemir, E. I."Effects of MPO‑463G/A and ‑129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population". Biomedical Reports 7, no. 6 (2017): 547-552. https://doi.org/10.3892/br.2017.995
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team