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Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease

  • Authors:
    • Jeong-Yun Yoon
    • Yeojin Lee
    • Seong-Lan Yu
    • Hee-Kyung Yoon
    • Ha-Yan Park
    • Chung-Il Joung
    • Seok-Rae Park
    • Mihye Kwon
    • Jaeku Kang
  • View Affiliations / Copyright

    Affiliations: Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea, Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea, Department of Internal Medicine, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea
    Copyright: © Yoon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 520-526
    |
    Published online on: October 4, 2017
       https://doi.org/10.3892/br.2017.996
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Abstract

Despite extensive studies, the pathogenesis of Behçet's disease (BD) remains unclear. In particular, the roles of B cells in patients with BD have not been elucidated. Activation-induced cytidine deaminase (AID) is a critical enzyme for immunoglobulin (Ig) heavy chain class switching and somatic hypermutation in B cells and the abnormal expression of AID in various immune conditions has previously been studied. B10 cells, an interleukin (IL)-10-secreting subset of regulatory B cells, function to downregulate inflammation and autoimmunity. Thus, in the present study, the relevance of B cells in patients with BD was investigated. The plasma levels of IL-10 and IgA and the proportions of cluster of differentiation (CD)43+ B cells, excluding naïve B cells, were measured in 16 patients with BD and 16 age- and sex-matched healthy controls (HCs). Additionally, the mRNA levels of IL-10 and AID were assessed in B cells from fresh peripheral blood samples of the BD patients and HCs. The plasma level of IL-10 in patients with BD did not differ significantly from that in HCs. Similarly, there was no significant difference in the plasma level of IgA, although a slight increase was observed in patients with BD compared with that in HCs. There were no differences in CD43+CD19+ B cell numbers between patients with BD and HCs. However, IL-10 mRNA levels were significantly reduced (P<0.05), while AID mRNA levels were significantly increased (P<0.01) in the B cells of patients with BD compared with those in HCs. These results provide insight into the role of B cells in patients with BD.
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Copy and paste a formatted citation
Spandidos Publications style
Yoon J, Lee Y, Yu S, Yoon H, Park H, Joung C, Park S, Kwon M and Kang J: Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease. Biomed Rep 7: 520-526, 2017.
APA
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C. ... Kang, J. (2017). Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease. Biomedical Reports, 7, 520-526. https://doi.org/10.3892/br.2017.996
MLA
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C., Park, S., Kwon, M., Kang, J."Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease". Biomedical Reports 7.6 (2017): 520-526.
Chicago
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C., Park, S., Kwon, M., Kang, J."Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease". Biomedical Reports 7, no. 6 (2017): 520-526. https://doi.org/10.3892/br.2017.996
Copy and paste a formatted citation
x
Spandidos Publications style
Yoon J, Lee Y, Yu S, Yoon H, Park H, Joung C, Park S, Kwon M and Kang J: Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease. Biomed Rep 7: 520-526, 2017.
APA
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C. ... Kang, J. (2017). Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease. Biomedical Reports, 7, 520-526. https://doi.org/10.3892/br.2017.996
MLA
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C., Park, S., Kwon, M., Kang, J."Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease". Biomedical Reports 7.6 (2017): 520-526.
Chicago
Yoon, J., Lee, Y., Yu, S., Yoon, H., Park, H., Joung, C., Park, S., Kwon, M., Kang, J."Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease". Biomedical Reports 7, no. 6 (2017): 520-526. https://doi.org/10.3892/br.2017.996
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