High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer

Xia,Peixuan; Chu,Shihua; Liu,Geng; Chen,Guoqing; Yi,Tao; Feng,Shi; Zhou,Hongying

doi:10.3892/br.2018.1061

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Article Open Access

High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer

Authors:
- Peixuan Xia
- Shihua Chu
- Geng Liu
- Guoqing Chen
- Tao Yi
- Shi Feng
- Hongying Zhou
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Affiliations: Department of Human Anatomy, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Biotherapy Laboratory of Gynecological Oncology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China

Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 343-349
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Published online on: February 9, 2018

https://doi.org/10.3892/br.2018.1061
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Abstract

Kinesin Family Member 3A (KIF3A) was recognized as a key factor of ciliogenesis and transport system of primary cilia in normal cells. However, its possible function on cancer cells has yet to be identified. In the present study, microarray tissue chips, including 230 breast cancer samples, were applied to determine the KIF3A expression pattern by immunological histological chemistry. Statistical analysis on the KIF3A expression level and the currently used clinicopathological characteristics of breast cancer patients was carried out. Follow‑up data of these patients over 10 years were also used to evaluate the relationship between KIF3A and the survival rate. The expression levels of KIF3A were significantly higher in 140 breast cancer tissues than those of 90 para‑carcinoma samples, which served as controls (P<0.001). In addition, in a further 70 paired samples, the same higher expression level was observed in cancer tissues compared with their self‑paired controls (P<0.001). Furthermore, the high expression of KIF3A in breast cancer tissue correlated with the status of estrogen receptor, androgen receptor, epidermal growth factor receptor and Ki‑67 of breast cancer patients, and were also related to their pathology grade and lymph node metastasis. The survival analysis showed a better survival rate in the patients with a higher expression level of KIF3A. Collectively, the triadic associations of KIF3A, the currently used clinicopathological parameters and survival rate suggest that KIF3A is involved in the tumorigenesis and progression of breast cancer. Thus, KIF3A could be considered a promising novel prognostic index in breast cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer

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