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Review Open Access

Clinical applications of mesenchymal stem cells in chronic lung diseases (Review)

  • Authors:
    • Katerina M. Antoniou
    • Konstantinos Karagiannis
    • Eliza Tsitoura
    • Eleni Bibaki
    • Ismini Lasithiotaki
    • Athanasia Proklou
    • Demetrios A. Spandidos
    • Nikos Tzanakis
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular and Cellular Pneumonology, Medical School, University of Crete, Heraklion 71110, Crete, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, Voutes, Heraklion 71003, Crete, Greece, Department of Thoracic Medicine, Interstitial Lung Disease Unit, University Hospital, University of Crete, Heraklion 71110, Crete, Greece
    Copyright: © Antoniou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 314-318
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/br.2018.1067
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Abstract

Mesenchymal stem (stromal) cells (MSCs) are multipotent stromal cells that have the ability to modulate immune response to tissue injury and promote repair in vivo. The therapeutic potential of ex vivo expanded MSCs are currently under investigation for a variety of chronic and acute lung diseases. This review summarizes the encouraging results regarding the safety of MSCs administration from recent and current clinical trials for idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and chronic obstructive pulmonary disease. It also reviews the early preliminary data extracted by the same trials regarding the efficacy of MSCs in the aforementioned lung diseases.
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1 

Fuchs E and Segre JA: Stem cells: A new lease on life. Cell. 100:143–155. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Gomperts BN and Strieter RM: Stem cells and chronic lung disease. Annu Rev Med. 58:285–298. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Rankin S: Mesenchymal stem cells. Thorax. 67:565–566. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Crystal RG, Randell SH, Engelhardt JF, Voynow J and Sunday ME: Airway epithelial cells: Current concepts and challenges. Proc Am Thorac Soc. 5:pp. 772–777. 2008; View Article : Google Scholar : PubMed/NCBI

5 

Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, et al: Evidence for human lung stem cells. N Engl J Med. 364:1795–1806. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Rankin SM: Chemokines and adult bone marrow stem cells. Immunol Lett. 145:47–54. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Gupta N, Su X, Popov B, Lee JW, Serikov V and Matthay MA: Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 179:1855–1863. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Iyer SS and Rojas M: Anti-inflammatory effects of mesenchymal stem cells: Novel concept for future therapies. Expert Opin Biol Ther. 8:569–581. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Krampera M, Pasini A, Pizzolo G, Cosmi L, Romagnani S and Annunziato F: Regenerative and immunomodulatory potential of mesenchymal stem cells. Curr Opin Pharmacol. 6:435–441. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Weiss DJ, Kolls JK, Ortiz LA, Panoskaltsis-Mortari A and Prockop DJ: Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 5:pp. 637–667. 2008; View Article : Google Scholar : PubMed/NCBI

11 

Schuleri KH, Feigenbaum GS, Centola M, Weiss ES, Zimmet JM, Turney J, Kellner J, Zviman MM, Hatzistergos KE, Detrick B, et al: Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy. Eur Heart J. 30:2722–2732. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, Ishino K, Ishida H, Shimizu T, Kangawa K, et al: Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 12:459–465. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Ishizawa K, Kubo H, Yamada M, Kobayashi S, Numasaki M, Ueda S, Suzuki T and Sasaki H: Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. FEBS Lett. 556:249–252. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Spees JL, Pociask DA, Sullivan DE, Whitney MJ, Lasky JA, Prockop DJ and Brody AR: Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med. 176:385–394. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, et al: Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 302:L829–L837. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT and Jacks T: Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 121:823–835. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Jarvinen L, Badri L, Wettlaufer S, Ohtsuka T, Standiford TJ, Toews GB, Pinsky DJ, Peters-Golden M and Lama VN: Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol. 181:4389–4396. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Toonkel RL, Hare JM, Matthay MA and Glassberg MK; Potential for Clinical Testing, : Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med. 188:133–140. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tzouvelekis A, Paspaliaris V, Koliakos G, Ntolios P, Bouros E, Oikonomou A, Zissimopoulos A, Boussios N, Dardzinski B, Gritzalis D, et al: A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis. J Transl Med. 11:1712013. View Article : Google Scholar : PubMed/NCBI

20 

Chambers DC, Enever D, Ilic N, Sparks L, Whitelaw K, Ayres J, Yerkovich ST, Khalil D, Atkinson KM and Hopkins PM: A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis. Respirology. 19:1013–1018. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Glassberg MK, Minkiewicz J, Toonkel RL, Simonet ES, Rubio GA, DiFede D, Shafazand S, Khan A, Pujol MV, LaRussa VF, et al: Allogeneic Human Mesenchymal Stem Cells in Patients With Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER): A Phase I Safety Clinical Trial. Chest. 151:971–981. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L and Slutsky AS; ARDS Definition Task Force, : Acute respiratory distress syndrome: The Berlin Definition. JAMA. 307:2526–2533. 2012.PubMed/NCBI

23 

Matthay MA, Ware LB and Zimmerman GA: The acute respiratory distress syndrome. J Clin Invest. 122:2731–2740. 2012. View Article : Google Scholar : PubMed/NCBI

24 

McIntyre BA, Alev C, Mechael R, Salci KR, Lee JB, Fiebig-Comyn A, Guezguez B, Wu Y, Sheng G and Bhatia M: Expansive generation of functional airway epithelium from human embryonic stem cells. Stem Cells Transl Med. 3:7–17. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hao Q, Zhu YG, Monsel A, Gennai S, Lee T, Xu F and Lee JW: Study of Bone Marrow and Embryonic Stem Cell-Derived Human Mesenchymal Stem Cells for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice. Stem Cells Transl Med. 4:832–840. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Rafat N, Dacho C, Kowanetz G, Betzen C, Tönshoff B, Yard B and Beck G: Bone marrow-derived progenitor cells attenuate inflammation in lipopolysaccharide-induced acute respiratory distress syndrome. BMC Res Notes. 7:6132014. View Article : Google Scholar : PubMed/NCBI

27 

Yin X, Liang Z, Yun Y and Pei L: Intravenous Transplantation of BMP2-Transduced Endothelial Progenitor Cells Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats. Cell Physiol Biochem. 35:2149–2158. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, et al: Mesenchymal stem (stromal) cells for treatment of ARDS: A phase 1 clinical trial. Lancet Respir Med. 3:24–32. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, et al: Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: A randomized, placebo-controlled pilot study. Respir Res. 15:392014. View Article : Google Scholar : PubMed/NCBI

30 

Shigemura N, Okumura M, Mizuno S, Imanishi Y, Matsuyama A, Shiono H, Nakamura T and Sawa Y: Lung tissue engineering technique with adipose stromal cells improves surgical outcome for pulmonary emphysema. Am J Respir Crit Care Med. 174:1199–1205. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Zhen G, Xue Z, Zhao J, Gu N, Tang Z, Xu Y and Zhang Z: Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells. Cytotherapy. 12:605–614. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Weiss DJ, Casaburi R, Flannery R, LeRoux-Williams M and Tashkin DP: A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest. 143:1590–1598. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, Oostendorp J, Bajema I, Versteegh MI, Taube C, et al: A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. QJM. 109:331–336. 2016. View Article : Google Scholar : PubMed/NCBI

34 

U.S. National Library of Medicine, . Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysema. ClinicalTrials.gov Identifier: NCT01872624. https://clinicaltrials.gov/ct2/show/record/NCT01872624March 25–2015, pp. 3

35 

ClinicalTrials.gov Identifier: NCT01872624. Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysema.

36 

Ribeiro-Paes JT, Bilaqui A, Greco OT, Ruiz MA, Marcelino MY, Stessuk T, de Faria C and Lago MR: Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema. Int J Chron Obstruct Pulmon Dis:. 6:63–71. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Baughman RPI, Culver DA, Jankovi V, Fischkoff S, Brockway G and Lower EE: Placenta-derived mesenchymal-like cells (PDA-001) as therapy for chronic pulmonary sarcoidosis: A phase 1 study. Sarcoidosis Vasc Diffuse Lung Dis. 32:106–14. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Antoniou KM, Karagiannis K, Tsitoura E, Bibaki E, Lasithiotaki I, Proklou A, Spandidos DA and Tzanakis N: Clinical applications of mesenchymal stem cells in chronic lung diseases (Review). Biomed Rep 8: 314-318, 2018.
APA
Antoniou, K.M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A. ... Tzanakis, N. (2018). Clinical applications of mesenchymal stem cells in chronic lung diseases (Review). Biomedical Reports, 8, 314-318. https://doi.org/10.3892/br.2018.1067
MLA
Antoniou, K. M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A., Spandidos, D. A., Tzanakis, N."Clinical applications of mesenchymal stem cells in chronic lung diseases (Review)". Biomedical Reports 8.4 (2018): 314-318.
Chicago
Antoniou, K. M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A., Spandidos, D. A., Tzanakis, N."Clinical applications of mesenchymal stem cells in chronic lung diseases (Review)". Biomedical Reports 8, no. 4 (2018): 314-318. https://doi.org/10.3892/br.2018.1067
Copy and paste a formatted citation
x
Spandidos Publications style
Antoniou KM, Karagiannis K, Tsitoura E, Bibaki E, Lasithiotaki I, Proklou A, Spandidos DA and Tzanakis N: Clinical applications of mesenchymal stem cells in chronic lung diseases (Review). Biomed Rep 8: 314-318, 2018.
APA
Antoniou, K.M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A. ... Tzanakis, N. (2018). Clinical applications of mesenchymal stem cells in chronic lung diseases (Review). Biomedical Reports, 8, 314-318. https://doi.org/10.3892/br.2018.1067
MLA
Antoniou, K. M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A., Spandidos, D. A., Tzanakis, N."Clinical applications of mesenchymal stem cells in chronic lung diseases (Review)". Biomedical Reports 8.4 (2018): 314-318.
Chicago
Antoniou, K. M., Karagiannis, K., Tsitoura, E., Bibaki, E., Lasithiotaki, I., Proklou, A., Spandidos, D. A., Tzanakis, N."Clinical applications of mesenchymal stem cells in chronic lung diseases (Review)". Biomedical Reports 8, no. 4 (2018): 314-318. https://doi.org/10.3892/br.2018.1067
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