Open Access

Oxidative stress and kidney injury in trans-radial catheterization

  • Authors:
    • Konstantinos Tsarouhas
    • Christina Tsitsimpikou
    • Xrisoula Papantoni
    • Dimitra Lazaridou
    • Michael Koutouzis
    • Savvas Mazzaris
    • Ramin Rezaee
    • Charalambos Mamoulakis
    • Panagiotis Georgoulias
    • Charitini Nepka
    • Elias Rentoukas
    • Zenon Kyriakides
    • Aristidis Tsatsakis
    • Demetrios A. Spandidos
    • Demetrios Kouretas
  • View Affiliations

  • Published online on: February 28, 2018     https://doi.org/10.3892/br.2018.1071
  • Pages: 417-425
  • Copyright: © Tsarouhas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled. Reduced glutathione, catalase, thiobarbituric acid reactive species (TBARS) levels and total anti-oxidant status were measured at various time points postangiography. In ischemic patients baseline TBARS levels were 2‑fold lower compared to controls, while carbonyls levels were 35% higher. Glutathione was almost 4‑fold lower than the control group. Glutathione and lipid peroxidation in ischemic patients gradually increased after contrast medium administration and reached 180% (P<0.001) and 20% (P=0.021) after 4-6 h, respectively. Four patients presented early evidence of contrast‑induced nephropathy postangiography, while no control patient developed acute kidney injury. In the multiple logistic regression analysis, only the creatinine levels at baseline influenced the frequency of early contrast-induced nephropathy development (β =0.36, 95% CI: 0.285-0.438, P=0.01). Glutathione low levels were dominant in the baseline values of ischemic patients who developed contrast-induced nephropathy. Glutathione levels rapidly increased while protein oxidation decreased at the expense of lipid peroxidation. In conclusion, early oxidative stress changes occur in trans-radial CA patients with a mild profile, sufficient to mobilize patient antioxidant defenses.
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May-2018
Volume 8 Issue 5

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Spandidos Publications style
Tsarouhas K, Tsitsimpikou C, Papantoni X, Lazaridou D, Koutouzis M, Mazzaris S, Rezaee R, Mamoulakis C, Georgoulias P, Nepka C, Nepka C, et al: Oxidative stress and kidney injury in trans-radial catheterization. Biomed Rep 8: 417-425, 2018
APA
Tsarouhas, K., Tsitsimpikou, C., Papantoni, X., Lazaridou, D., Koutouzis, M., Mazzaris, S. ... Kouretas, D. (2018). Oxidative stress and kidney injury in trans-radial catheterization. Biomedical Reports, 8, 417-425. https://doi.org/10.3892/br.2018.1071
MLA
Tsarouhas, K., Tsitsimpikou, C., Papantoni, X., Lazaridou, D., Koutouzis, M., Mazzaris, S., Rezaee, R., Mamoulakis, C., Georgoulias, P., Nepka, C., Rentoukas, E., Kyriakides, Z., Tsatsakis, A., Spandidos, D. A., Kouretas, D."Oxidative stress and kidney injury in trans-radial catheterization". Biomedical Reports 8.5 (2018): 417-425.
Chicago
Tsarouhas, K., Tsitsimpikou, C., Papantoni, X., Lazaridou, D., Koutouzis, M., Mazzaris, S., Rezaee, R., Mamoulakis, C., Georgoulias, P., Nepka, C., Rentoukas, E., Kyriakides, Z., Tsatsakis, A., Spandidos, D. A., Kouretas, D."Oxidative stress and kidney injury in trans-radial catheterization". Biomedical Reports 8, no. 5 (2018): 417-425. https://doi.org/10.3892/br.2018.1071