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Review

Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)

  • Authors:
    • Dongyu Li
    • Chenghao Hu
    • Huibin Li
  • View Affiliations / Copyright

    Affiliations: Department of Genetics, College of Agricultural and Life Science, University of Wisconsin‑Madison, Madison, WI 53706, USA, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261000, P.R. China, Department of Burns and Plastic Surgery, People's Hospital of Linyi, Linyi, Shandong 276000, P.R. China
  • Pages: 399-406
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    Published online on: March 13, 2018
       https://doi.org/10.3892/br.2018.1077
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Abstract

Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors and embryonic tissues and is associated with tumor cell differentiation, proliferation, invasion and metastasis; however, survivin is expressed at low levels in normal terminally differentiated adult tissues. Meanwhile, the expression level of survivin is also a negative prognostic factor for patients with cancer. These unique characteristics of survivin make it an exciting potential therapeutic target for cancer treatment. This review will discuss the biological characteristics of survivin and its potential use as a treatment target to reduce cancer cell proliferation.
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Copy and paste a formatted citation
Spandidos Publications style
Li D, Hu C and Li H: Survivin as a novel target protein for reducing the proliferation of cancer cells (Review). Biomed Rep 8: 399-406, 2018.
APA
Li, D., Hu, C., & Li, H. (2018). Survivin as a novel target protein for reducing the proliferation of cancer cells (Review). Biomedical Reports, 8, 399-406. https://doi.org/10.3892/br.2018.1077
MLA
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8.5 (2018): 399-406.
Chicago
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8, no. 5 (2018): 399-406. https://doi.org/10.3892/br.2018.1077
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Hu C and Li H: Survivin as a novel target protein for reducing the proliferation of cancer cells (Review). Biomed Rep 8: 399-406, 2018.
APA
Li, D., Hu, C., & Li, H. (2018). Survivin as a novel target protein for reducing the proliferation of cancer cells (Review). Biomedical Reports, 8, 399-406. https://doi.org/10.3892/br.2018.1077
MLA
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8.5 (2018): 399-406.
Chicago
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8, no. 5 (2018): 399-406. https://doi.org/10.3892/br.2018.1077
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