Significance of data analysis in the quality control of prenatal screening for Down syndrome

Li,Yahong; Zhang,Xiaojuan; Hong,Dongyang; Guan,Xianwei; Lv,Shaolei; Sun,Yun; Jiang,Tao

doi:10.3892/br.2018.1078

May-2018 Volume 8 Issue 5

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May-2018 Volume 8 Issue 5

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Article

Significance of data analysis in the quality control of prenatal screening for Down syndrome

Authors:
- Yahong Li
- Xiaojuan Zhang
- Dongyang Hong
- Xianwei Guan
- Shaolei Lv
- Yun Sun
- Tao Jiang
View Affiliations / Copyright

Affiliations: Center of Prenatal Diagnosis, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu 210004, P.R. China, Zhejiang Biosan Biochemical Technologies Co., Ltd., Hangzhou, Zhejiang 310000, P.R. China
Pages: 447-453
|
Published online on: March 15, 2018

https://doi.org/10.3892/br.2018.1078
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Abstract

Dual detection of α‑fetoprotein (AFP) and free β‑human chorionic gonadotropin (β‑HCG) is a common screening method for Down syndrome in the second trimester and its efficacy is assessed by false‑positive rate (FPR). The present study aimed to investigate the effects of the bias in median multiple of the median (mMoM) values of AFP and free β‑HCG on FPR. The bias in mMoM values of AFP and free β‑HCG and the bias in mMoM values under different gestational ages and weight groups were analyzed. Median equations were adjusted, and medians in LifeCycle software were replaced by local medians. Following two adjustments of the median equations, all indices including FPR, mMoM values of markers and mMoM values under different gestational ages and weight groups generally reached an ideal state. In conclusion, abnormal bias in mMoM values may prompt aberrant application of median equations, and regular monitoring of these indicators may be important for quality control in prenatal screening.

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1	Smith M and Visootsak J: Noninvasive screening tools for Down syndrome: A review. Int J Womens Health. 5:125–131. 2013.PubMed/NCBI
2	Duan Y, Li Y and Xue Q: Serological prenatal screening and diagnosis for Down syndrome. Clin Exp Obstet Gynecol. 41:572–574. 2014.PubMed/NCBI
3	Huang J, Chen Y and Pong RW: Factors influencing prenatal screening for Down's syndrome: Evidence from Zhejiang (China). Asia Pac J Public Health. 27:NP1288–NP1297. 2015. View Article : Google Scholar : PubMed/NCBI
4	Sirichotiyakul S, Luewan S, Sekararith R and Tongsong T: False positive rate of serum markers for Down syndrome screening: Does transportation have any effect? J Med Assoc Thai. 95:152–155. 2012.PubMed/NCBI
5	Wald NJ, Barnes IM, Birger R and Huttly W: Effect on Down syndrome screening performance of adjusting for marker levels in a previous pregnancy. Prenat Diagn. 26:539–544. 2006. View Article : Google Scholar : PubMed/NCBI
6	Androutsopoulos G, Gkogkos P and Decavalas G: Mid-trimester maternal serum HCG and alpha fetal protein levels: Clinical significance and prediction of adverse pregnancy outcome. Int J Endocrinol Metab. 11:102–106. 2013. View Article : Google Scholar : PubMed/NCBI
7	Extermann P, Bischof P, Marguerat P and Mermillod B: Second-trimester maternal serum screening for Down's syndrome: Free beta-human chorionic gonadotrophin (HCG) and alpha-fetoprotein, with or without unconjugated oestriol, compared with total HCG, alpha-fetoprotein and unconjugated oestriol. Hum Reprod. 13:220–223. 1998. View Article : Google Scholar : PubMed/NCBI
8	Sayin NC, Canda MT, Ahmet N, Arda S, Süt N and Varol FG: The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns. Arch Gynecol Obstet. 277:47–53. 2008. View Article : Google Scholar : PubMed/NCBI
9	Shaw SW, Lin SY, Lin CH, Su YN, Cheng PJ, Lee CN and Chen CP: Second-trimester maternal serum quadruple test for Down syndrome screening: A Taiwanese population-based study. Taiwan J Obstet Gynecol. 49:30–34. 2010. View Article : Google Scholar : PubMed/NCBI
10	Nix B, Wright D and Baker A: The impact of bias in MoM values on patient risk and screening performance for Down syndrome. Prenat Diagn. 27:840–845. 2007. View Article : Google Scholar : PubMed/NCBI
11	Bishop J, Dunstan FD, Nix BJ and Reynolds TM: The effects of gestation dating on the calculation of patient specific risks in Down's syndrome screening. Ann Clin Biochem. 32:464–477. 1995. View Article : Google Scholar : PubMed/NCBI
12	Li Y, Zhang X, Sun Y, Hong D, Wang Y, Xu Z and Jiang T: Combined detection of α-fetoprotein and free β-human chorionic gonadotropin in screening for trisomy 21 and management of cases in the moderate risk value range. Mol Clin Oncol. 7:623–628. 2017. View Article : Google Scholar : PubMed/NCBI
13	Parikh AM, Park AM and Sumfest J: Cumulative summation (CUSUM) charts in the monitoring of hypospadias outcomes: A tool for quality improvement initiative. J Pediatr Urol. 10:306–311. 2014. View Article : Google Scholar : PubMed/NCBI
14	Leandro G, Rolando N, Gallus G, Rolles K and Burroughs AK: Monitoring surgical and medical outcomes: The Bernoulli cumulative SUM chart. A novel application to assess clinical interventions. Postgrad Med J. 81:647–652. 2005. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of data analysis in the quality control of prenatal screening for Down syndrome

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