Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model

Ogawa,Hisataka; Konno,Masamitsu; Kawamoto,Koichi; Nishida,Naohiro; Koseki,Jun; Mizushima,Tsunekazu; Satoh,Taroh; Eguchi,Hidetoshi; Doki,Yuichiro; Mori,Masaki; Ishii,Hideshi

doi:10.3892/br.2018.1080

May-2018 Volume 8 Issue 5

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May-2018 Volume 8 Issue 5

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Article

Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model

Authors:
- Hisataka Ogawa
- Masamitsu Konno
- Koichi Kawamoto
- Naohiro Nishida
- Jun Koseki
- Tsunekazu Mizushima
- Taroh Satoh
- Hidetoshi Eguchi
- Yuichiro Doki
- Masaki Mori
- Hideshi Ishii
View Affiliations / Copyright

Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Department of Cancer Profiling Discovery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan
Pages: 497-499
|
Published online on: March 21, 2018

https://doi.org/10.3892/br.2018.1080
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Abstract

Fetal cells in the developmental stages function with a distinct mechanism in comparison to adult tissues, which may be a useful source for regenerative medicine in postnatal medicine; however, the precise molecular mechanism remains to be elucidated fully. The present study investigated murine fetal hepatocytes, which were cultured in vitro, and the supernatants were used for the culture with murine adipose tissue‑derived cells. Notably, the results indicated that fetal hepatocyte‑derived culture medium elicits the induction of differentiation of adipose tissue‑derived cells to bile duct cell lineages, but not to hepatocyte lineages in mice. This indicates that fetal cells possess the multi potentials, which are already absent in adults, and may be useful for regenerative medicine in future.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Fetal hepatocyte-derived culture medium elicits adipocyte differentiation to bile duct cell lineages in a mouse model

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