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Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus

  • Authors:
    • Ji Hyeon Ahn
    • Joon Seok Lee
    • Jun Hwi Cho
    • Joon Ha Park
    • Tae‑Kyeong Lee
    • Minah Song
    • Hyunjung Kim
    • Seok Hoon Kang
    • Moo‑Ho Won
    • Choong Hyun Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Emergency Medicine and Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Medical Education, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Chungcheongnam 31116, Republic of Korea
  • Pages: 517-522
    |
    Published online on: May 4, 2018
       https://doi.org/10.3892/br.2018.1094
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Abstract

Nuclear receptor related‑1 protein (Nurr1) serves important roles in hippocampal‑dependent cognitive process. In the present study, the protein expression of Nurr1 was compared in the hippocampi of young [postnatal month 3 (PM 3)], adult (PM 12) and aged (PM 24) gerbils using western blot analysis and immunohistochemistry. Results indicated that the protein level of Nurr1 was significantly and gradually decreased in the gerbil hippocampus with increasing age. In addition, strong Nurr1 immunoreactivity was primarily observed in pyramidal neurons and granule cells of the hippocampus in the young group, which was determined to be reduced in the adult group and to a greater extent in the aged group. Collectively the data demonstrated that Nurr1 immunoreactivity was gradually and markedly decreased during normal aging. These results indicate that gradual decrease of Nurr1 expression in the hippocampus may be associated with the normal aging process and a decline in hippocampus‑dependent cognitive function.
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1 

Bustamante J, Czerniczyniec A, Cymeryng C and Lores-Arnaiz S: Age related changes from youth to adulthood in rat brain cortex: Nitric oxide synthase and mitochondrial respiratory function. Neurochem Res. 33:1216–1223. 2008. View Article : Google Scholar : PubMed/NCBI

2 

He WB, Zhang JL, Hu JF, Zhang Y, Machida T and Chen NH: Effects of glucocorticoids on age-related impairments of hippocampal structure and function in mice. Cell Mol Neurobiol. 28:277–291. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Park JA, Park JH, Ahn JH, Kim JD, Won MH and Lee CH: Age dependent increase in the expression of antioxidant like protein 1 in the gerbil hippocampus. Mol Med Rep. 14:3215–3219. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Brim BL, Haskell R, Awedikian R, Ellinwood NM, Jin L, Kumar A, Foster TC and Magnusson KR: Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor. Behav Brain Res. 238:211–226. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Loza Márquez A, Elias V, Wong CP, Ho E, Bermudez M and Magnusson KR: Effects of ibuprofen on cognition and NMDA receptor subunit expression across aging. Neuroscience. 344:276–292. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Geinisman Y, Detoledo-Morrell L, Morrell F and Heller RE: Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives. Prog Neurobiol. 45:223–252. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Jacobson L, Zhang R, Elliffe D, Chen KF, Mathai S, McCarthy D, Waldvogel H and Guan J: Correlation of cellular changes and spatial memory during aging in rats. Exp Gerontol. 43:929–938. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Law SW, Conneely OM, DeMayo FJ and O'Malley BW: Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 6:2129–2135. 1992. View Article : Google Scholar : PubMed/NCBI

9 

Zetterström RH, Williams R, Perlmann T and Olson L: Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. Brain Res Mol Brain Res. 41:111–120. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Jiang C, Wan X, He Y, Pan T, Jankovic J and Le W: Age-dependent dopaminergic dysfunction in Nurr1 knockout mice. Exp Neurol. 191:154–162. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Johnson MM, Michelhaugh SK, Bouhamdan M, Schmidt CJ and Bannon MJ: The transcription factor NURR1 exerts concentration-dependent effects on target genes mediating distinct biological processes. Front Neurosci. 5:1352011. View Article : Google Scholar : PubMed/NCBI

12 

Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, et al: Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci. 29:15923–15932. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Liu H, Wei L, Tao Q, Deng H, Ming M, Xu P and Le W: Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease. Eur J Neurol. 19:870–875. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zetterström RH, Solomin L, Jansson L, Hoffer BJ, Olson L and Perlmann T: Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:248–250. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Zheng K, Heydari B and Simon DK: A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease. Arch Neurol. 60:722–725. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH and Glass CK: A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 137:47–59. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kim JI, Jeon SG, Kim KA, Kim YJ, Song EJ, Choi J, Ahn KJ, Kim CJ, Chung HY, Moon M, et al: The pharmacological stimulation of Nurr1 improves cognitive functions via enhancement of adult hippocampal neurogenesis. Stem Cell Res (Amst). 17:534–543. 2016. View Article : Google Scholar

18 

Tokuoka H, Hatanaka T, Metzger D and Ichinose H: Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. Neurosci Lett. 559:50–55. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Chu Y, Kompoliti K, Cochran EJ, Mufson EJ and Kordower JH: Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J Comp Neurol. 450:203–214. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Parkinson GM, Dayas CV and Smith DW: Age-related gene expression changes in substantia nigra dopamine neurons of the rat. Mech Ageing Dev. 149:41–49. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Kitabatake Y, Sailor KA, Ming GL and Song H: Adult neurogenesis and hippocampal memory function: New cells, more plasticity, new memories? Neurosurg Clin N Am. 18:105–113. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Cheal ML: The gerbil: A unique model for research on aging. Exp Aging Res. 12:3–21. 1986. View Article : Google Scholar : PubMed/NCBI

23 

National Research Council: Guide for the Care and Use of Laboratory Animals. 8th edition. National Acadamies Press; Washington, DC: 2011

24 

Choi HS, Ahn JH, Park JH, Won MH and Lee CH: Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Mol Med Rep. 13:2409–2414. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Lee CH and Won MH: Increased dynamin-1 and −2 protein expression in the aged gerbil hippocampus. Cell Mol Neurobiol. 34:791–796. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Himeda T, Mizuno K, Kato H and Araki T: Effects of age on immunohistochemical changes in the mouse hippocampus. Mech Ageing Dev. 126:673–677. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Ahn JH, Shin BN, Park JH, Kim IH, Cho JH, Chen B, Lee TK, Tae HJ, Lee JC, Cho JH, et al: Long-term observation of neuronal degeneration and microgliosis in the gerbil dentate gyrus after transient cerebral ischemia. J Neurol Sci. 363:21–26. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Jinno S and Kosaka T: Stereological estimation of numerical densities of glutamatergic principal neurons in the mouse hippocampus. Hippocampus. 20:829–840. 2010.PubMed/NCBI

29 

Moon M, Jeong I, Kim CH, Kim J, Lee PK, Mook-Jung I, Leblanc P and Kim KS: Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease. J Neurochem. 132:254–262. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Zhang L, Le W, Xie W and Dani JA: Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease. Neurobiol Aging. 33(1001): e7–16. 2012.

31 

McNulty SE, Barrett RM, Vogel-Ciernia A, Malvaez M, Hernandez N, Davatolhagh MF, Matheos DP, Schiffman A and Wood MA: Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory. Learn Mem. 19:588–592. 2012. View Article : Google Scholar : PubMed/NCBI

32 

McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA and Wood MA: HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci. 31:764–774. 2011. View Article : Google Scholar : PubMed/NCBI

33 

de Ortiz Peña S, Maldonado-Vlaar CS and Carrasquillo Y: Hippocampal expression of the orphan nuclear receptor gene hzf-3/nurr1 during spatial discrimination learning. Neurobiol Learn Mem. 74:161–178. 2000. View Article : Google Scholar : PubMed/NCBI

34 

von Hertzen LS and Giese KP: Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. J Neurosci. 25:1935–1942. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Colón-Cesario WI, Martínez-Montemayor MM, Morales S, Félix J, Cruz J, Adorno M, Pereira L, Colón N, Maldonado-Vlaar CS and de Ortiz Peña S: Knockdown of Nurr1 in the rat hippocampus: Implications to spatial discrimination learning and memory. Learn Mem. 13:734–744. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Neves G, Cooke SF and Bliss TV: Synaptic plasticity, memory and the hippocampus: A neural network approach to causality. Nat Rev Neurosci. 9:65–75. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL and Spruston N: Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors. Neuron. 76:776–789. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Lopez-Rojas J and Kreutz MR: Mature granule cells of the dentate gyrus - Passive bystanders or principal performers in hippocampal function? Neurosci Biobehav Rev. 64:167–174. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Das SR and Magnusson KR: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging. Behav Brain Res. 222:122–133. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Yanai S, Ito H and Endo S: Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice. Neuropharmacology. 129:57–68. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Zamzow DR, Elias V, Shumaker M, Larson C and Magnusson KR: An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging. J Neurosci. 33:12300–12305. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ahn JH, Lee JS, Cho JH, Park JH, Lee TK, Song M, Kim H, Kang SH, Won MH, Lee CH, Lee CH, et al: Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus. Biomed Rep 8: 517-522, 2018.
APA
Ahn, J.H., Lee, J.S., Cho, J.H., Park, J.H., Lee, T., Song, M. ... Lee, C.H. (2018). Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus. Biomedical Reports, 8, 517-522. https://doi.org/10.3892/br.2018.1094
MLA
Ahn, J. H., Lee, J. S., Cho, J. H., Park, J. H., Lee, T., Song, M., Kim, H., Kang, S. H., Won, M., Lee, C. H."Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus". Biomedical Reports 8.6 (2018): 517-522.
Chicago
Ahn, J. H., Lee, J. S., Cho, J. H., Park, J. H., Lee, T., Song, M., Kim, H., Kang, S. H., Won, M., Lee, C. H."Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus". Biomedical Reports 8, no. 6 (2018): 517-522. https://doi.org/10.3892/br.2018.1094
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn JH, Lee JS, Cho JH, Park JH, Lee TK, Song M, Kim H, Kang SH, Won MH, Lee CH, Lee CH, et al: Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus. Biomed Rep 8: 517-522, 2018.
APA
Ahn, J.H., Lee, J.S., Cho, J.H., Park, J.H., Lee, T., Song, M. ... Lee, C.H. (2018). Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus. Biomedical Reports, 8, 517-522. https://doi.org/10.3892/br.2018.1094
MLA
Ahn, J. H., Lee, J. S., Cho, J. H., Park, J. H., Lee, T., Song, M., Kim, H., Kang, S. H., Won, M., Lee, C. H."Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus". Biomedical Reports 8.6 (2018): 517-522.
Chicago
Ahn, J. H., Lee, J. S., Cho, J. H., Park, J. H., Lee, T., Song, M., Kim, H., Kang, S. H., Won, M., Lee, C. H."Age‑dependent decrease of Nurr1 protein expression in the gerbil hippocampus". Biomedical Reports 8, no. 6 (2018): 517-522. https://doi.org/10.3892/br.2018.1094
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