Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2018 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis

  • Authors:
    • Hu Wang
    • Li Wang
    • Yujia Cheng
    • Zhiqing Xia
    • Yifeng Liao
    • Jiang Cao
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 90-96
    |
    Published online on: May 22, 2018
       https://doi.org/10.3892/br.2018.1100
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present meta‑analysis, the efficacy and safety of orlistat in the treatment of non‑alcoholic fatty liver (NAFLD) and non‑alcoholic steatohepatitis (NASH) were evaluated. PubMed, Embase, the Cochrane Library, Web of Science, and Wan Fang data were searched for controlled trials of orlistat in patients with NAFLD or NASH, published before August 2017. Three randomized controlled trials and four single‑arm trials were included. The involved participants with NAFLD or NASH (330 patients) were analyzed for clinical outcomes including alteration in hepatic histological variables and biomarkers of liver function. Improvements were observed in levels of alanine aminotransferase [standard mean difference (SMD)=‑1.41; P=0.01], aspartate aminotransferase (SMD=‑2.06; P=0.0005), γ‑glutamyl transpeptidase (SMD=‑1.91; P=0.05), glucose [mean difference (MD)=‑0.51; P=0.01], triglycerides (MD=‑0.93; P=0.01), homeostasis model assessment of insulin resistance index (MD=‑1.05; P=0.04) and body mass index (MD=‑1.97; P=0.02), but not in liver fibrosis score (SMD=‑0.14; P=0.71). On sub‑analyses of the different patient groups, no significant differences were observed in patients with NASH. Taken together, these findings demonstrate that orlistat could serve as a therapeutic drug to improve biochemical indicators of liver damage, but not as first‑choice drug for the management of NAFLD or NASH; thus suggesting a novel palliative drug only for the treatment of NAFLD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bellentani S, Scaglioni F, Marino M and Bedogni G: Epidemiology of non-alcoholic fatty liver disease. Dig Dis. 28:155–161. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Lazo M and Clark JM: The epidemiology of nonalcoholic fatty liver disease: A global perspective. Semin Liver Dis. 28:339–350. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Zhu JZ, Dai YN, Wang YM, Zhou QY, Yu CH and Li YM: Prevalence of nonalcoholic fatty liver disease and economy. Dig Dis Sci. 60:3194–3202. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Vanni E, Bugianesi E, Kotronen A, de Minicis S, Yki-Järvinen H and Svegliati-Baroni G: From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis. 42:320–330. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Li L, Liu DW, Yan HY, Wang ZY, Zhao SH and Wang B: Obesity is an independent risk factor for non-alcoholic fatty liver disease: Evidence from a meta-analysis of 21 cohort studies. Obes Rev. 17:510–519. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhao ZH, Liu XL and Fan JG: Research on the natural history of non-alcoholic fatty liver disease should be taken seriously. Zhonghua Gan Zang Bing Za Zhi. 25:81–84. 2017.(In Chinese). PubMed/NCBI

7 

Bhala N, Angulo P, van der Poorten D, Lee E, Hui JM, Saracco G, Adams LA, Charatcharoenwitthaya P, Topping JH, Bugianesi E, et al: The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study. Hepatology. 54:1208–1216. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Duvnjak M, Tomasic V, Gomercic M, Smircic Duvnjak L, Barsic N and Lerotic I: Therapy of nonalcoholic fatty liver disease: Current status. J Physiol Pharmacol. 60(Suppl 7): 57–66. 2009.PubMed/NCBI

9 

Narayanaswami V and Dwoskin LP: Obesity: Current and potential pharmacotherapeutics and targets. Pharmacol Ther. 170:116–147. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Kushner RF: Medical management of obesity. Semin Gastrointest Dis. 13:123–132. 2002.PubMed/NCBI

11 

Ali Khan R, Kapur P, Jain A, Farah F and Bhandari U: Effect of orlistat on periostin, adiponectin, inflammatory markers and ultrasound grades of fatty liver in obese NAFLD patients. Ther Clin Risk Manag. 13:139–149. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Chen Z, Liang B, Wang Y and Fan X: The analysis of the efficacy and risk factors in obesity with non-alcoholic fatty liver disease subjects treated with orlistat. Chin J Clin Hepatol. 22:123–124. 2006.(In Chinese).

13 

Harrison SA, Fincke C, Helinski D, Torgerson S and Hayashi P: A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients. Aliment Pharmacol Ther. 20:623–628. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Fernández S and Córdoba M: Progesterone causes metabolic changes involving aminotransferases and creatine kinase in cryopreserved bovine spermatozoa. Anim Reprod Sci. 164:90–96. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Bruinsma BG, Wu W, Ozer S, Farmer A, Markmann JF, Yeh H and Uygun K: Warm ischemic injury is reflected in the release of injury markers during cold preservation of the human liver. PLoS One. 10:e01234212015. View Article : Google Scholar : PubMed/NCBI

16 

Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP and Elisaf MS: Orlistat-associated adverse effects and drug interactions: A critical review. Drug Saf. 31:53–65. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Zelber-Sagi S, Kessler A, Brazowsky E, Webb M, Lurie Y, Santo M, Leshno M, Blendis L, Halpern Z and Oren R: A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 4:639–644. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Moher D, Liberati A, Tetzlaff J and Altman DG; PRISMA Group: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 8:336–341. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Furlan AD, Pennick V, Bombardier C and van Tulder M; Editorial Board, Cochrane Back Review Group: 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine. 34:1929–1941. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Li Z, Xue J, Chen P, Chen L, Yan S and Liu L: Prevalence of nonalcoholic fatty liver disease in mainland of China: A meta-analysis of published studies. J Gastroenterol Hepatol. 29:42–51. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Fan Z, Qiu D, Xie W, Hu H, Chen Y, Sun Z, Liu S and Zeng M: Clinical study of obesity associated non-alcoholic fatty liver disease. Chin Hepatol. 9:155–158. 2004.(In Chinese).

23 

Harrison SA, Fecht W, Brunt EM and Neuschwander-Tetri BA: Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial. Hepatology. 49:80–86. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Hussein O, Grosovski M, Schlesinger S, Szvalb S and Assy N: Orlistat reverse fatty infiltration and improves hepatic fibrosis in obese patients with nonalcoholic steatohepatitis (NASH). Dig Dis Sci. 52:2512–2519. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, Enders F, Saksena S, Burt AD, Bida JP, et al: The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 45:846–854. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Mahboub P, Ottens P, Seelen M, 't Hart N, van Goor H, Ploeg R, Martins PN and Leuvenink H: Gradual rewarming with gradual increase in pressure during machine perfusion after cold static preservation reduces kidney ischemia reperfusion injury. PLoS One. 11:e01520062016. View Article : Google Scholar : PubMed/NCBI

27 

Tilg H and Moschen A: Weight loss: Cornerstone in the treatment of non-alcoholic fatty liver disease. Minerva Gastroenterol Dietol. 56:159–167. 2010.PubMed/NCBI

28 

Gabriel FS, Samson CE, Abejuela ZR, Sicat-Gabriel PR, Sumpio JP, Zacarias MB and Mercado-Asis LB: Postprandial effect of orlistat on the peaking of lipid level after sequential high fat meals. Int J Endocrinol Metab. 10:458–463. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Nakou ES, Filippatos TD, Agouridis AP, Kostara C, Bairaktari ET and Elisaf MS: The effects of ezetimibe and/or orlistat on triglyceride-rich lipoprotein metabolism in obese hypercholesterolemic patients. Lipids. 45:445–450. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Kujawska-Łuczak M, Musialik K, Szulińska M, Swora-Cwynar E, Kargulewicz A, Grzymisławska M, Pupek-Musialik D and Bogdański P: The effect of orlistat versus metformin on body composition and insulin resistance in obese premenopausal women: 3-month randomized prospective open-label study. Arch Med Sci. 13:725–731. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Scheen AJ and van Gaal LF: Combating the dual burden: Therapeutic targeting of common pathways in obesity and type 2 diabetes. Lancet Diabetes Endocrinol. 2:911–922. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Smith-Marsh D: Pharmacological strategies for preventing type 2 diabetes in patients with impaired glucose tolerance. Drugs Today (Barc). 49:499–507. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M and Sanyal AJ; American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterologyh: The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 142:1592–1609. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wang L, Cheng Y, Xia Z, Liao Y and Cao J: Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis. Biomed Rep 9: 90-96, 2018.
APA
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., & Cao, J. (2018). Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis. Biomedical Reports, 9, 90-96. https://doi.org/10.3892/br.2018.1100
MLA
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., Cao, J."Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis". Biomedical Reports 9.1 (2018): 90-96.
Chicago
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., Cao, J."Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis". Biomedical Reports 9, no. 1 (2018): 90-96. https://doi.org/10.3892/br.2018.1100
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wang L, Cheng Y, Xia Z, Liao Y and Cao J: Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis. Biomed Rep 9: 90-96, 2018.
APA
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., & Cao, J. (2018). Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis. Biomedical Reports, 9, 90-96. https://doi.org/10.3892/br.2018.1100
MLA
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., Cao, J."Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis". Biomedical Reports 9.1 (2018): 90-96.
Chicago
Wang, H., Wang, L., Cheng, Y., Xia, Z., Liao, Y., Cao, J."Efficacy of orlistat in non‑alcoholic fatty liver disease: A systematic review and meta‑analysis". Biomedical Reports 9, no. 1 (2018): 90-96. https://doi.org/10.3892/br.2018.1100
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team