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MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands

  • Authors:
    • Liyan Gu
    • Qingxin Xu
    • Haitao Liu
    • Jingru Xie
    • Lide Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China, Graduate School of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China, The General Hospital of Chinese Armed Police Force, Beijing 100089, P.R. China, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, P.R. China
  • Pages: 142-146
    |
    Published online on: June 1, 2018
       https://doi.org/10.3892/br.2018.1106
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Abstract

Hyperplasia of mammary glands (HMG) is also termed mammary dysplasia. In China, the number of patients suffering from breast hyperplasia is increasing annually. MicroRNAs (miRNAs; length, 19‑24 nucleotides), a group of small endogenous non‑coding RNAs, post‑transcriptionally regulate gene expression via RNA interference and gene silencing pathways. The cause of disease of HMG because remains unclear. Thus, the aim of the present study was to establish comprehensive profile of drug treatments following at different time intervals on rat models of differentially expressed miRNAs, using miRNA microarray data. After scanning the chip, 13 up‑regulated and 20 down‑regulated miRNAs were identified. MiR‑31 and miR‑30 exhibited different expression levels between rats exhibiting mammary gland hyperplasia treated with or without Jiedu Capsule water solution once a day for 4 weeks, and the two demonstrated a strong association with HMG and breast cancer. Therefore, the functions of these miRNAs may provide the basis for further investigation of HMG.
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Copy and paste a formatted citation
Spandidos Publications style
Gu L, Xu Q, Liu H, Xie J and Zhang L: MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands. Biomed Rep 9: 142-146, 2018.
APA
Gu, L., Xu, Q., Liu, H., Xie, J., & Zhang, L. (2018). MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands. Biomedical Reports, 9, 142-146. https://doi.org/10.3892/br.2018.1106
MLA
Gu, L., Xu, Q., Liu, H., Xie, J., Zhang, L."MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands". Biomedical Reports 9.2 (2018): 142-146.
Chicago
Gu, L., Xu, Q., Liu, H., Xie, J., Zhang, L."MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands". Biomedical Reports 9, no. 2 (2018): 142-146. https://doi.org/10.3892/br.2018.1106
Copy and paste a formatted citation
x
Spandidos Publications style
Gu L, Xu Q, Liu H, Xie J and Zhang L: MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands. Biomed Rep 9: 142-146, 2018.
APA
Gu, L., Xu, Q., Liu, H., Xie, J., & Zhang, L. (2018). MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands. Biomedical Reports, 9, 142-146. https://doi.org/10.3892/br.2018.1106
MLA
Gu, L., Xu, Q., Liu, H., Xie, J., Zhang, L."MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands". Biomedical Reports 9.2 (2018): 142-146.
Chicago
Gu, L., Xu, Q., Liu, H., Xie, J., Zhang, L."MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands". Biomedical Reports 9, no. 2 (2018): 142-146. https://doi.org/10.3892/br.2018.1106
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