miR‑124‑3p acts as a potential marker and suppresses tumor growth in gastric cancer

Liu,Feng; Hu,Hongjuan; Zhao,Jianfu; Zhang,Zhiwei; Ai,Xiaohong; Tang,Liyun; Xie,Liming

doi:10.3892/br.2018.1113

miR‑124‑3p acts as a potential marker and suppresses tumor growth in gastric cancer

Authors:
- Feng Liu
- Hongjuan Hu
- Jianfu Zhao
- Zhiwei Zhang
- Xiaohong Ai
- Liyun Tang
- Liming Xie
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Affiliations: Medical School of University of South China, Hengyang, Hunan 421001, P.R. China, University of South China School of Nursing, Hengyang, Hunan 421001, P.R. China, Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510630, P.R. China, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
Published online on: June 20, 2018 https://doi.org/10.3892/br.2018.1113
Pages: 147-155
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

miR‑124‑3p has been implicated in a variety of cancers. The purpose of the present study was to investigate the expression, prognostic roles and functions of miR‑124‑3p in gastric cancer. Functional studies indicated that ectopic overexpression of miR‑124‑3p in gastric cancer cells suppressed cell viability and plate colony formation in vitro and tumor growth in vivo. In situ hybridization analysis demonstrated that decreased expression of miR‑124‑3p was associated with clinical stage and lymph node metastasis, as well as shorter overall survival and disease‑free survival rates. Furthermore, it was observed that miR‑124‑3p repressed the carcinogenesis of gastric cancer by targeting Ras‑related C3 botulinum toxin substrate 1 (Rac1) and specificity protein 1 (SP1). Collectively, these results indicate a potential underlying mechanism for the regulation of gastric cancer by miR‑124‑3p involving targeting of Rac1 and SP1. Thus, miR‑124‑3p may be an independent indicator of survival and treatment strategy for patients with gastric cancer.

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