Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review)

  • Authors:
    • Hiroshi Kobayashi
    • Naoki Kawahara
    • Kenji Ogawa
    • Yuki Yamada
    • Kana Iwai
    • Emiko Niiro
    • Sachiko Morioka
  • View Affiliations

  • Published online on: June 20, 2018     https://doi.org/10.3892/br.2018.1114
  • Pages: 112-118
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Abstract

Targeting non‑oncogenes may result in the selective death of cancer cells. Clear cell carcinoma of the ovary (CCC) may exhibit resistance against conventional chemotherapy and is associated with poor prognosis. The aim of the present report was to review synthetic lethality‑based therapies for CCC. Previous English‑language studies were reviewed to accumulate preclinical and clinical data on targeting synthetic lethal partners. Synthetic lethal interactions have a variety of types, involving components of a backup or parallel pathway with overlapping functions, components encoded by paralogous pairs, subunit components that form heteromeric complexes and components that are arranged in a single linear pathway. A set of candidate gene targets potentially resulting in synthetic lethality have been previously identified. HNF class homeobox, AT‑rich interaction domain 1A, ATR serine/threonine kinase, ATM serine/threonine kinase, checkpoint kinase 1 and phosphatase and tensin homolog may be the key partner genes. A variety of loss of function genes in CCC are driver or passenger events and may function as synthetic lethal pairs under replication stress conditions. Further clinical studies will be required to investigate the safety and therapeutic effect of synthetic lethality pairs in CCC tumor types with replication stress.
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August-2018
Volume 9 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Kobayashi H, Kawahara N, Ogawa K, Yamada Y, Iwai K, Niiro E and Morioka S: Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review). Biomed Rep 9: 112-118, 2018
APA
Kobayashi, H., Kawahara, N., Ogawa, K., Yamada, Y., Iwai, K., Niiro, E., & Morioka, S. (2018). Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review). Biomedical Reports, 9, 112-118. https://doi.org/10.3892/br.2018.1114
MLA
Kobayashi, H., Kawahara, N., Ogawa, K., Yamada, Y., Iwai, K., Niiro, E., Morioka, S."Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review)". Biomedical Reports 9.2 (2018): 112-118.
Chicago
Kobayashi, H., Kawahara, N., Ogawa, K., Yamada, Y., Iwai, K., Niiro, E., Morioka, S."Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review)". Biomedical Reports 9, no. 2 (2018): 112-118. https://doi.org/10.3892/br.2018.1114