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Biomedical Reports
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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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August-2018 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer

  • Authors:
    • Ebru Esin Yörüker
    • Metin Keskin
    • Cemil Burak Kulle
    • Stefan Holdenrieder
    • Ugur Gezer

  • View Affiliations / Copyright

    Affiliations: Department of Basic Oncology, Istanbul University Oncology Institute, Capa, 34093 Istanbul, Turkey, Department of Surgery, Istanbul Medical Faculty, Istanbul University, Capa, 34093 Istanbul, Turkey, Ιnstitute of Laboratory Medicine, German Heart Center Munich, Technical University of Munich, D‑80333 Munich, Germany
  • Pages: 181-186
    |
    Published online on: June 22, 2018
       https://doi.org/10.3892/br.2018.1116
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Abstract

Gastric cancer (GC) is among the most frequent malignant diseases. Despite advances in treatment, the clinical outcome of patients with GC remains poor. The establishment of novel biomarkers is urgently required for early detection, treatment evaluation and prognostic assessment. Non‑coding RNAs (ncRNAs) are a key topic of intensive research due to their potential applications in the field of oncology. The long ncRNA H19 has been frequently reported as overexpressed in many cancers including GC. In the present study, the diagnostic and prognostic value of circulating H19 in GC was assessed. Higher levels of circulating H19 were identified in GC patients (n=40) compared with a control group consisting of endoscopy‑verified GC‑free individuals (n=42; median levels relative to GAPDH, 58.4 vs. 29.9; P=0.027). Patients with smaller tumor sizes (<5 cm) exhibited higher H19 in their circulation compared with those with larger tumors (≥5 cm; P=0.04). Plasma levels of H19 declined significantly upon surgical removal of gastric tumors as documented in a subset of patients [n=20; relative median levels, 146.0 vs. 15.0 (pre‑surgery); P=0.003]. However, it was identified that H19 had no prognostic role in GC by the Kaplan‑Meier method. In conclusion, the present findings identify H19 as potential diagnostic marker in GC.

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Copy and paste a formatted citation
Spandidos Publications style
Yörüker EE, Keskin M, Kulle CB, Holdenrieder S and Gezer U: Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer. Biomed Rep 9: 181-186, 2018.
APA
Yörüker, E.E., Keskin, M., Kulle, C.B., Holdenrieder, S., & Gezer, U. (2018). Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer. Biomedical Reports, 9, 181-186. https://doi.org/10.3892/br.2018.1116
MLA
Yörüker, E. E., Keskin, M., Kulle, C. B., Holdenrieder, S., Gezer, U."Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer". Biomedical Reports 9.2 (2018): 181-186.
Chicago
Yörüker, E. E., Keskin, M., Kulle, C. B., Holdenrieder, S., Gezer, U."Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer". Biomedical Reports 9, no. 2 (2018): 181-186. https://doi.org/10.3892/br.2018.1116
Copy and paste a formatted citation
x
Spandidos Publications style
Yörüker EE, Keskin M, Kulle CB, Holdenrieder S and Gezer U: Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer. Biomed Rep 9: 181-186, 2018.
APA
Yörüker, E.E., Keskin, M., Kulle, C.B., Holdenrieder, S., & Gezer, U. (2018). Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer. Biomedical Reports, 9, 181-186. https://doi.org/10.3892/br.2018.1116
MLA
Yörüker, E. E., Keskin, M., Kulle, C. B., Holdenrieder, S., Gezer, U."Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer". Biomedical Reports 9.2 (2018): 181-186.
Chicago
Yörüker, E. E., Keskin, M., Kulle, C. B., Holdenrieder, S., Gezer, U."Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer". Biomedical Reports 9, no. 2 (2018): 181-186. https://doi.org/10.3892/br.2018.1116
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