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Article

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease

  • Authors:
    • Versa Omrani‑Nava
    • Akbar Hedayatizadeh‑Omran
    • Reza Alizadeh‑Navaei
    • Vahid Mokhberi
    • Rozita Jalalian
    • Ghasem Janbabaei
    • Omolbanin Amjadi
    • Ghasem Rahmatpour
    • Amir Mozaffari
  • View Affiliations / Copyright

    Affiliations: Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Mazandaran 48166‑33131, Iran, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Mazandaran 48471-91971, Iran
  • Pages: 259-265
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/br.2018.1121
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Abstract

Chronic diseases including coronary artery disease (CAD) impose a high burden in terms of mortality and disability particularly in developing countries. Both genetic and environmental risk factors confer susceptibility to CAD. Meanwhile, a functional polymorphism in the tumor protein p53 (TP53) gene (codon 72, exon 4) has been reported to be associated with a wide range of cancers and inflammatory disorders. There are controversies regarding CAD and involvement of the TP53 codon 72 single nucleotide polymorphism; therefore, the present case‑control study was conducted to evaluate the potential association between this TP53 polymorphism and CAD in an Iranian population. A total of 153 subjects (including 70 patients diagnosed with CAD and 83 subjects with normal coronary parameters, determined by angiography) were genotyped for the TP53 (rs1042522) polymorphism by the polymerase chain reaction‑restriction fragment length polymorphism technique. Clinical and laboratory findings were also evaluated. The χ2 test and unpaired Student's t‑test were applied to compare genotype and allele distributions and clinical characteristics between the two groups. Significant associations of the Pro72 allele [odds ratio (OR)=1.66, P=0.027] and Pro/Pro genotype (OR=2.91, P=0.022) with CAD were identified. No associations between patients' clinical findings and genotypes were apparent. Therefore, according to present findings, the TP53 Pro72 allele may be involved in the development of CAD along with conventional risk factors in patients from Northern Iran.
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Copy and paste a formatted citation
Spandidos Publications style
Omrani‑Nava V, Hedayatizadeh‑Omran A, Alizadeh‑Navaei R, Mokhberi V, Jalalian R, Janbabaei G, Amjadi O, Rahmatpour G and Mozaffari A: TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease. Biomed Rep 9: 259-265, 2018.
APA
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G. ... Mozaffari, A. (2018). TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease. Biomedical Reports, 9, 259-265. https://doi.org/10.3892/br.2018.1121
MLA
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G., Amjadi, O., Rahmatpour, G., Mozaffari, A."TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease". Biomedical Reports 9.3 (2018): 259-265.
Chicago
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G., Amjadi, O., Rahmatpour, G., Mozaffari, A."TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease". Biomedical Reports 9, no. 3 (2018): 259-265. https://doi.org/10.3892/br.2018.1121
Copy and paste a formatted citation
x
Spandidos Publications style
Omrani‑Nava V, Hedayatizadeh‑Omran A, Alizadeh‑Navaei R, Mokhberi V, Jalalian R, Janbabaei G, Amjadi O, Rahmatpour G and Mozaffari A: TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease. Biomed Rep 9: 259-265, 2018.
APA
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G. ... Mozaffari, A. (2018). TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease. Biomedical Reports, 9, 259-265. https://doi.org/10.3892/br.2018.1121
MLA
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G., Amjadi, O., Rahmatpour, G., Mozaffari, A."TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease". Biomedical Reports 9.3 (2018): 259-265.
Chicago
Omrani‑Nava, V., Hedayatizadeh‑Omran, A., Alizadeh‑Navaei, R., Mokhberi, V., Jalalian, R., Janbabaei, G., Amjadi, O., Rahmatpour, G., Mozaffari, A."TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease". Biomedical Reports 9, no. 3 (2018): 259-265. https://doi.org/10.3892/br.2018.1121
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