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Article

Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease

  • Authors:
    • Dongzhi Ran
    • Baogang Xie
    • Zongjie Gan
    • Xicui Sun
    • Huaiyu Gu
    • Junqing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Chongqing Medical University, The Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016, P.R. China, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21042, USA, Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou 510080, P.R. China
  • Pages: 221-226
    |
    Published online on: July 5, 2018
       https://doi.org/10.3892/br.2018.1125
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Abstract

As the most common genetic cause of Parkinson's disease (PD), the role of human leucine‑rich repeat kinase 2 (hLRRK2) in the efficacy of PD treatment is a focus of study. Our previous study demonstrated that mushroom body (MB) expression of hLRRK2 in Drosophila could recapitulate the clinical feature of sleep disturbances observed in PD patients, and melatonin (MT) treatment could attenuate the hLRRK2‑induced sleep disorders and synaptic dysfunction, suggesting the therapeutic potential of MT in PD patients carrying hLRRK2 mutations; however, no further study into the impacts on memory deficit was conducted. Therefore, in the current paper, the study of the effects of MT on hLRRK2 flies was continued, to determine its potential role in the improvement of memory deficit in PD. To achieve this, the Drosophila learning and memory phases, including short‑ and long‑term memory, were recorded; furthermore, the effect of MT on calcium channel activity during neurotransmission was detected using electrophysiology patch clamp recordings. It was demonstrated that MT treatment reversed hLRRK2‑induced long‑term memory deficits in Drosophila; furthermore, MT reduced MB calcium channel activities. These findings suggest that MT may exerts therapeutic effects on the long‑term memory of PD patients via calcium channel modulation, thus providing indication of its potential to maintain cognitive function in PD patients.
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1 

de Rijk MC, Launer LJ, Berger K, Breteler MM, Dartigues JF, Baldereschi M, Fratiglioni L, Lobo A, Martinez-Lage J, Trenkwalder C, et al: Neurologic Diseases in the Elderly Research Group: Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurology. 54 Suppl 5:S21–S23. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Farlow J, Pankratz ND, Wojcieszek J and Foroud T: Parkinson Disease OverviewAdam MP, Ardinger HH and Pagon RA: NCBI Bookshelf. Gene, GeneReviews® (Internet). Seattle (WA): University of Washington, Seattle; 1993–2018

3 

Tolosa E, Gaig C, Santamaria J and Compta Y: Diagnosis and the premotor phase of Parkinson disease. Neurology. 72:S12–S20. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Hely MA, Morris JG, Reid WG and Trafficante R: Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov Disord. 20:190–199. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H and Kragh-Sørensen P: Risk of dementia in Parkinson's disease: A community-based, prospective study. Neurology. 56:730–736. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Melton AW: Implications of short-term memory for a general theory of memory 1. J Verbal Learn Verbal Behav. 2:1–21. 1963. View Article : Google Scholar

7 

Sagar HJ, Sullivan EV, Gabrieli JDE, Corkin S and Growdon JH: Temporal ordering and short-term memory deficits in Parkinson's disease. Brain. 111:525–539. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Sullivan EV and Sagar HJ: Double dissociation of short-term and long-term memory for nonverbal material in Parkinson's disease and global amnesia. A further analysis. Brain. 114:893–906. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Whittington CJ, Podd J and Kan MM: Recognition memory impairment in Parkinson's disease: Power and meta-analyses. Neuropsychology. 14:233–246. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Hardeland R, Pandi-Perumal SR and Cardinali DP: Melatonin. Int J Biochem Cell Biol. 38:313–316. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Altun A and Ugur-Altun B: Melatonin: Therapeutic and clinical utilization. Int J Clin Pract. 61:835–845. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S and Robakis NK: Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci. 17:1683–1690. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Mackay TF and Anholt RR: Of flies and man: Drosophila as a model for human complex traits. Annu Rev Genomics Hum Genet. 7:339–367. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Koh K, Evans JM, Hendricks JC and Sehgal A: A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci USA. 103:13843–13847. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Sun X, Ran D, Zhao X, Huang Y, Long S, Liang F, Guo W, Nucifora FC Jr, Gu H, Lu X, et al: Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease. Mol Med Rep. 13:3936–3944. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Greggio E and Cookson MR: Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions. Asn Neuro. 1:e000022009. View Article : Google Scholar : PubMed/NCBI

17 

Liu Z, Wang X, Yu Y, Li X, Wang T, Jiang H, Ren Q, Jiao Y, Sawa A, Moran T, et al: A Drosophila model for LRRK2-linked parkinsonism. Proc Natl Acad Sci USA. 105:2693–2698. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Tully T and Quinn WG: Classical conditioning and retention in normal and mutant Drosophila melanogaster. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 157:263–277. 1985. View Article : Google Scholar

19 

Akalal DB, Wilson CF, Zong L, Tanaka NK, Ito K and Davis RL: Roles for Drosophila mushroom body neurons in olfactory learning and memory. Learn Mem. 13:659–668. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Pinton P, de Virgilio M, Fogarty KE and Rizzuto R: Behaviour, learning and memoryDrosophila: A Practical Approach. Connolly JB and Tully T: IRL. Oxford University Press; Oxford: pp. 265–317. 1998

21 

Videnovic A, Lazar AS, Barker RA and Overeem S: ‘The clocks that time us’ - circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 10:683–693. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B and Hardeland R: Melatonin: Nature's most versatile biological signal? FEBS J. 273:2813–2838. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Pierpaoli W, Dall'Ara A, Pedrinis E and Regelson W: The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Ann N Y Acad Sci. 621:(1 Physiological). 291–313. 1991. View Article : Google Scholar : PubMed/NCBI

24 

Dori D, Casale G, Solerte SB, Fioravanti M, Migliorati G, Cuzzoni G and Ferrari E: Chrono-neuroendocrinological aspects of physiological aging and senile dementia. Chronobiologia. 21:121–126. 1994.PubMed/NCBI

25 

Mishima K, Okawa M, Hishikawa Y, Hozumi S, Hori H and Takahashi K: Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia. Acta Psychiatr Scand. 89:1–7. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB and Barker RA: Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease. Mov Disord. 31:1062–1066. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Tully T, Preat T, Boynton SC and Del Vecchio M: Genetic dissection of consolidated memory in Drosophila. Cell. 79:35–47. 1994. View Article : Google Scholar : PubMed/NCBI

28 

McGuire SE, Le PT and Davis RL: The role of Drosophila mushroom body signaling in olfactory memory. Science. 293:1330–1333. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Nichols WC, Pankratz N, Hernandez D, Paisán-Ruíz C, Jain S, Halter CA, Michaels VE, Reed T, Rudolph A, Shults CW, et al: Parkinson Study Group-PROGENI investigators: Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet. 365:410–412. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Di Fonzo A, Rohé CF, Ferreira J, Chien HF, Vacca L, Stocchi F, Guedes L, Fabrizio E, Manfredi M, Vanacore N, et al: Italian Parkinson Genetics Network: A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Lancet. 365:412–415. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Akalal DB, Yu D and Davis RL: A late-phase, long-term memory trace forms in the γ neurons of Drosophila mushroom bodies after olfactory classical conditioning. J Neurosci. 30:16699–16708. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Guadalupe A, Steffen H, Magdalena S and Juan B: TRP, TRPL and Cacophony Channels Mediate Ca2+ Influx and Exocytosis in Photoreceptors Axons in Drosophila. PLoS One. 7:1036. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Ran D, Xie B, Gan Z, Sun X, Gu H and Yang J: Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease. Biomed Rep 9: 221-226, 2018.
APA
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., & Yang, J. (2018). Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease. Biomedical Reports, 9, 221-226. https://doi.org/10.3892/br.2018.1125
MLA
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., Yang, J."Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease". Biomedical Reports 9.3 (2018): 221-226.
Chicago
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., Yang, J."Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease". Biomedical Reports 9, no. 3 (2018): 221-226. https://doi.org/10.3892/br.2018.1125
Copy and paste a formatted citation
x
Spandidos Publications style
Ran D, Xie B, Gan Z, Sun X, Gu H and Yang J: Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease. Biomed Rep 9: 221-226, 2018.
APA
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., & Yang, J. (2018). Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease. Biomedical Reports, 9, 221-226. https://doi.org/10.3892/br.2018.1125
MLA
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., Yang, J."Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease". Biomedical Reports 9.3 (2018): 221-226.
Chicago
Ran, D., Xie, B., Gan, Z., Sun, X., Gu, H., Yang, J."Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease". Biomedical Reports 9, no. 3 (2018): 221-226. https://doi.org/10.3892/br.2018.1125
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