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Article

Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population

  • Authors:
    • Behnaz Riazalhosseini
    • Zahurin Mohamed
    • Yamunah Devi Apalasamy
    • Noor Shafila Shafie
    • Rosmawati Mohamed
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia, Social Wellbeing Research Centre, Faculty of Economics and Administration, University of Malaya, Kuala Lumpur 50603, Malaysia , Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
  • Pages: 213-220
    |
    Published online on: July 9, 2018
       https://doi.org/10.3892/br.2018.1126
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Abstract

Interleukin-6 (IL-6) is a cytokine with a critical role in regulating the immune response to infectious disease. Studies have indicated that polymorphisms in the IL-6 gene may be linked to hepatitis B virus (HBV) infection. The purpose of the present study was to examine the association among IL-6 SNPs and haplotypes with HBV infection risk in a Malaysian population. A total of 1,246 Malaysian subjects with and without chronic hepatitis B were recruited for this study. Three IL-6 polymorphisms (rs2069837, rs1800796 and rs2066992) were genotyped using a Sequenom MassARRAY® platform. The results suggested that GC and CC genotypes of rs1800796 as well as GT and TT genotypes of rs2066992 were associated with protection against HBV infection (P<0.001). Furthermore, haplotypes GG and CT exhibited a significant association with protection against HBV (P=0.003 and =0.005, respectively); and haplotypes GG and CT exhibited a significant association with clearance of HBV infection (P=0.035 and =0.037, respectively). The present study indicates that two IL-6 SNPs (rs1800796 and rs2066992) are associated with clearance of chronic HBV or protection against HBV infection at allelic, genotypic and haplotypic levels.
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Copy and paste a formatted citation
Spandidos Publications style
Riazalhosseini B, Mohamed Z, Apalasamy Y, Shafie N and Mohamed R: Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomed Rep 9: 213-220, 2018.
APA
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., & Mohamed, R. (2018). Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomedical Reports, 9, 213-220. https://doi.org/10.3892/br.2018.1126
MLA
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., Mohamed, R."Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population". Biomedical Reports 9.3 (2018): 213-220.
Chicago
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., Mohamed, R."Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population". Biomedical Reports 9, no. 3 (2018): 213-220. https://doi.org/10.3892/br.2018.1126
Copy and paste a formatted citation
x
Spandidos Publications style
Riazalhosseini B, Mohamed Z, Apalasamy Y, Shafie N and Mohamed R: Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomed Rep 9: 213-220, 2018.
APA
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., & Mohamed, R. (2018). Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomedical Reports, 9, 213-220. https://doi.org/10.3892/br.2018.1126
MLA
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., Mohamed, R."Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population". Biomedical Reports 9.3 (2018): 213-220.
Chicago
Riazalhosseini, B., Mohamed, Z., Apalasamy, Y., Shafie, N., Mohamed, R."Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population". Biomedical Reports 9, no. 3 (2018): 213-220. https://doi.org/10.3892/br.2018.1126
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