Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
Article

Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity

  • Authors:
    • Diaa E.E. Rizk
    • Ghada Al-Kafaji
    • Ahmed A. Jaradat
    • Diab Al-Tayab
    • Moiz Bakhiet
    • Stefano Salvatore
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynaecology, College of Medicine and Medical Sciences, Arabian Gulf University, 26671 Manama, Kingdom of Bahrain, Department of Molecular Medicine, College of Medicine and Medical Sciences and Al-Jawhara Centre for Molecular Medicine, Genetics and Inherited Disorders, Arabian Gulf University, 26671 Manama, Kingdom of Bahrain, Department of Family and Community Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, 26671 Manama, Kingdom of Bahrain, Obstetrics and Gynaecology Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Hospital, I-20132 Milan, Italy
  • Pages: 233-240
    |
    Published online on: July 12, 2018
       https://doi.org/10.3892/br.2018.1129
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to measure the plasma levels of matrix metalloproteinases (MMP)-2 and -9 and their tissue inhibitors (TIMP)-1 and -2, as surrogate biomarkers for pelvic floor tissue integrity in young, healthy multi-ethnic women. This was hoped to elucidate ethnic vulnerability to support-related pelvic floor dysfunctions. The plasma levels of MMP-2 and -9 and TIMP-1 and -2 were measured by sandwich ELISA in nulliparous, young (18-29 years) women volunteers (n=85) from five ethnic groups [n=17/group; Bahrainis, other Arabs, Filipinos, Indians/Pakistanis and Caucasians (Italians)] and compared with levels in Italians as the reference group. It was identified that the levels of plasma MMP-2 were significantly higher in Italians than in Bahrainis (P<0.001) and Filipinos (P<0.001), but significantly lower than in Indians/Pakistanis (P=0.013); whereas, the levels of plasma MMP-9 were significantly higher in Italians than in Bahrainis (P=0.009) and Indians/Pakistanis (P<0.015). The levels of plasma TIMP-2 were significantly lower in Italians than in Indians/Pakistanis (P=0.003), but the levels of plasma TIMP-1 were significantly higher in Italians than in all other groups (P<0.05) excluding Bahrainis. Although MMP-2 correlated negatively with TIMP-2 and MMP-9 correlated positively with TIMP-1, both correlations were not significant (r=0.071, P=0.533 and r=0.197, P=0.8, respectively). In all ethnic groups, MMP-9 level correlated positively with BMI (r=0.26, P=0.02), and TIMP-2 level with age (r=0.23, P=0.045). Overall, the trends for higher levels of MMP-2 and -9 and lower levels of TIMP-2 in the plasma of Caucasian women may indicate a greater tendency for collagenolysis and weaker connective tissue with increased risk of developing pelvic floor dysfunctions, and thus may potentially serve as biomarkers for pelvic floor tissue integrity.
View Figures

Figure 1

Figure 2

View References

1 

Strinic T, Vulic M, Tomic S, Capkun V, Stipic I and Alujevic I: Matrix metalloproteinases-1, −2 expression in uterosacral ligaments from women with pelvic organ prolapse. Maturitas. 64:132–135. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Kerkhof MH, Hendriks L and Brölmann HA: Changes in connective tissue in patients with pelvic organ prolapse - a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct. 20:461–474. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Gabriel B, Watermann D, Hancke K, Gitsch G, Werner M, Tempfer C and zur Hausen A: Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 17:478–482. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Chen B, Wen Y, Wang H and Polan ML: Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women. Am J Obstet Gynecol. 189:59–65. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Min J, Li B, Liu C, Guo W, Hong S, Tang J and Hong L: Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts. Mol Med Rep. 15:3278–3284. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Suzme R, Yalcin O, Gurdol F, Gungor F and Bilir A: Connective tissue alterations in women with pelvic organ prolapse and urinary incontinence. Acta Obstet Gynecol Scand. 86:882–888. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Rahn DD, Acevedo JF and Word RA: Effect of vaginal distention on elastic fiber synthesis and matrix degradation in the vaginal wall: Potential role in the pathogenesis of pelvic organ prolapse. Am J Physiol Regul Integr Comp Physiol. 295:R1351–R1358. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Howard D, Delancey JO, Tunn R and Ashton-Miller JA: Racial differences in the structure and function of the stress urinary continence mechanism. Obstet Gynecol. 95:713–717. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Sewell CA, Chang E and Sultana CJ: Prevalence of genital prolapse in 3 ethnic groups. J Reprod Med. 52:769–773. 2007.PubMed/NCBI

10 

Rizk DE, Czechowski J and Ekelund L: Dynamic assessment of pelvic floor and bony pelvis morphologic condition with the use of magnetic resonance imaging in a multiethnic, nulliparous, and healthy female population. Am J Obstet Gynecol. 191:83–89. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Easley DC, Abramowitch SD and Moalli PA: Female pelvic floor biomechanics: Bridging the gap. Curr Opin Urol. 27:262–267. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Tayebjee MH, Lip GY, Blann AD and Macfadyen RJ: Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and −9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and −2. Thromb Res. 115:205–210. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Barber MD, Walters MD and Bump RC: Short forms of two condition-specific quality-of-life questionnaires for women with pelvic floor disorders (PFDI-20 and PFIQ-7). Am J Obstet Gynecol. 193:103–113. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Peeters SA, Engelen L, Buijs J, Jorsal A, Parving HH, Tarnow L, Rossing P, Schalkwijk CG and Stehouwer CD: Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: A 12-year follow-up study. Cardiovasc Diabetol. 16:552017. View Article : Google Scholar : PubMed/NCBI

15 

Masuhara K, Nakai T, Yamaguchi K, Yamasaki S and Sasaguri Y: Significant increases in serum and plasma concentrations of matrix metalloproteinases 3 and 9 in patients with rapidly destructive osteoarthritis of the hip. Arthritis Rheum. 46:2625–2631. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Rouy D, Ernens I, Jeanty C and Wagner DR: Plasma storage at −80 degrees C does not protect matrix metalloproteinase-9 from degradation. Anal Biochem. 338:294–298. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tayebjee MH, Karalis I, Nadar SK, Beevers DG, MacFadyen RJ and Lip GY: Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and −2 levels in gestational hypertension. Am J Hypertens. 18:325–329. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Estanol MV, Crisp CC, Oakley SH, Kleeman SD, Fellner AN and Pauls RN: Systemic markers of collagen metabolism and vitamin C in smokers and non-smokers with pelvic organ prolapse. Eur J Obstet Gynecol Reprod Biol. 184:58–64. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Jung K: Serum or plasma: What kind of blood sample should be used to measure circulating matrix metalloproteinases and their inhibitors? J Neuroimmunol. 162:1–2. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Chai TC, Moalli PA, Richter HE, Lake AG, Kim HY, Nager CW, Sirls LT, Brubaker L and Kusek JW: Preoperative urodynamic parameters (Valsalva leak point pressure and maximum urethral closure pressure), urinary collagen and plasma vitamin D levels as predictors of mid urethral sling surgery outcome. J Urol. 196:819–823. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chai TC, Richter HE, Moalli P, Keay S, Biggio J, Zong W, Curto T, Kim HY, Stoddard AM and Kusek JW: Inflammatory and tissue remodeling urinary biomarkers before and after mid urethral sling surgery for stress urinary incontinence. J Urol. 191:703–709. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wu JM, Visco AG, Grass EA, Craig DM, Fulton RG, Haynes C, Weidner AC and Shah SH: Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse. Obstet Gynecol. 120:587–593. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Ferrari MM, Rossi G, Biondi ML, Viganò P, Dell'utri C and Meschia M: Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse. Arch Gynecol Obstet. 285:1581–1586. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Rizk DE, Al-Kafaji G, Jaradat AA, Al-Tayab D, Bakhiet M and Salvatore S: Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity. Biomed Rep 9: 233-240, 2018.
APA
Rizk, D.E., Al-Kafaji, G., Jaradat, A.A., Al-Tayab, D., Bakhiet, M., & Salvatore, S. (2018). Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity. Biomedical Reports, 9, 233-240. https://doi.org/10.3892/br.2018.1129
MLA
Rizk, D. E., Al-Kafaji, G., Jaradat, A. A., Al-Tayab, D., Bakhiet, M., Salvatore, S."Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity". Biomedical Reports 9.3 (2018): 233-240.
Chicago
Rizk, D. E., Al-Kafaji, G., Jaradat, A. A., Al-Tayab, D., Bakhiet, M., Salvatore, S."Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity". Biomedical Reports 9, no. 3 (2018): 233-240. https://doi.org/10.3892/br.2018.1129
Copy and paste a formatted citation
x
Spandidos Publications style
Rizk DE, Al-Kafaji G, Jaradat AA, Al-Tayab D, Bakhiet M and Salvatore S: Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity. Biomed Rep 9: 233-240, 2018.
APA
Rizk, D.E., Al-Kafaji, G., Jaradat, A.A., Al-Tayab, D., Bakhiet, M., & Salvatore, S. (2018). Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity. Biomedical Reports, 9, 233-240. https://doi.org/10.3892/br.2018.1129
MLA
Rizk, D. E., Al-Kafaji, G., Jaradat, A. A., Al-Tayab, D., Bakhiet, M., Salvatore, S."Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity". Biomedical Reports 9.3 (2018): 233-240.
Chicago
Rizk, D. E., Al-Kafaji, G., Jaradat, A. A., Al-Tayab, D., Bakhiet, M., Salvatore, S."Circulating matrix metalloproteinases and their tissue inhibitors as markers for ethnic variation in pelvic floor tissue integrity". Biomedical Reports 9, no. 3 (2018): 233-240. https://doi.org/10.3892/br.2018.1129
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team