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Article

Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis

  • Authors:
    • Jixu Yu
    • Nian Wang
    • Faying Qi
    • Xianjun Wang
    • Qiyi Zhu
    • Yucheng Lu
    • Huiling Zhang
    • Fengyuan Che
    • Wei Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China, Central Laboratory, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China, Clinical Laboratory, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China
  • Pages: 333-338
    |
    Published online on: August 2, 2018
       https://doi.org/10.3892/br.2018.1138
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Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. The mechanism that defines the loss of neurons in ALS is still not clearly understood, and there is no effective therapy to block its progression. Previous studies indicate that a disorder of iron homeostasis exists in ALS and based on this, the change of serum iron and ferritin and the association between iron metabolism and clinical features in Chinese Han patients with ALS was further investigated in the present study, in order to define its pathogenesis. Two cohorts were established: An ALS group consisting of 24 patients and a control group consisting of 38 healthy volunteers. Venous blood samples were collected for serum iron and ferritin analysis. The results indicated that the levels of serum iron were significantly decreased in patients with ALS (P<0.05), while there was no significant difference in serum ferritin between the ALS and control groups. However, the levels of serum ferritin were increased significantly in ALS patients with bulbar-onset (vs. limb-onset in females), dysphagia (vs. without dysphagia), longer disease duration (>12 months vs. ≤12 months in males) and lower ALS Functional Rating Scale-Revised score (<33 vs. ≥33; P<0.05). These results suggested that there was dysregulation of iron metabolism in Chinese Han patients with ALS and that serum ferritin may be a candidate biomarker of aggravation in these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Wang N, Qi F, Wang X, Zhu Q, Lu Y, Zhang H, Che F and Li W: Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis. Biomed Rep 9: 333-338, 2018.
APA
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y. ... Li, W. (2018). Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis. Biomedical Reports, 9, 333-338. https://doi.org/10.3892/br.2018.1138
MLA
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y., Zhang, H., Che, F., Li, W."Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis". Biomedical Reports 9.4 (2018): 333-338.
Chicago
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y., Zhang, H., Che, F., Li, W."Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis". Biomedical Reports 9, no. 4 (2018): 333-338. https://doi.org/10.3892/br.2018.1138
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Wang N, Qi F, Wang X, Zhu Q, Lu Y, Zhang H, Che F and Li W: Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis. Biomed Rep 9: 333-338, 2018.
APA
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y. ... Li, W. (2018). Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis. Biomedical Reports, 9, 333-338. https://doi.org/10.3892/br.2018.1138
MLA
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y., Zhang, H., Che, F., Li, W."Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis". Biomedical Reports 9.4 (2018): 333-338.
Chicago
Yu, J., Wang, N., Qi, F., Wang, X., Zhu, Q., Lu, Y., Zhang, H., Che, F., Li, W."Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis". Biomedical Reports 9, no. 4 (2018): 333-338. https://doi.org/10.3892/br.2018.1138
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