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Article

Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity

  • Authors:
    • Jian-Ping Xiao
    • Dao-Yang Wang
    • Xue-Rong Wang
    • Liang Yuan
    • Li Hao
    • De-Guang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Nephrology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China
  • Pages: 339-344
    |
    Published online on: August 3, 2018
       https://doi.org/10.3892/br.2018.1139
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Abstract

To investigate the clinical significance of the ratio of T helper cell 17 (Th17) cells to single immunoglobulin IL-1-related receptor (SIGIRR)+ cluster of differentiation (CD4)+ T cells in patients with systemic lupus erythematosus (SLE), novel data and data from previous studies were analyzed. The frequency of Th17 cells in peripheral blood mononuclear cells (PBMCs) and their correlation with clinical data were evaluated in 48 patients with SLE and 38 healthy controls through flow cytometry. Compared with healthy controls, the percentage of Th17 cells was significantly increased in the PBMCs of patients with SLE (Z=-5.82, P<0.001). Compared with inactive SLE (ISLE), the percentage of Th17 cells in active SLE (ASLE) were significantly increased (Z=-4.26, P<0.0001). Compared with patients without lupus nephritis, the frequency of Th17 cells was significant increased (Z=-2.20, P=0.028). The frequency of Th17 cells was inversely correlated with the frequency of SIGIRR+CD4+ T cells (r=-0.61, P<0.001). The ratio of Th17 cells to SIGIRR+CD4+ T cells in ASLE was significantly increased compared with healthy controls or patients with ISLE (P<0.001) and was inversely correlated with complement component 3 and complement component 4, and positively correlated with SLE disease activity index and 24-h proteinuria (P<0.05). In summary, increased numbers of Th17 cells and decreased numbers of SIGIRR+CD4+ T cells in patients with SLE suggested that SIGIRR+CD4+ T and Th17 cells may be involved in the pathogenesis of SLE.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao J, Wang D, Wang X, Yuan L, Hao L and Wang D: Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity. Biomed Rep 9: 339-344, 2018.
APA
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., & Wang, D. (2018). Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity. Biomedical Reports, 9, 339-344. https://doi.org/10.3892/br.2018.1139
MLA
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., Wang, D."Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity". Biomedical Reports 9.4 (2018): 339-344.
Chicago
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., Wang, D."Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity". Biomedical Reports 9, no. 4 (2018): 339-344. https://doi.org/10.3892/br.2018.1139
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao J, Wang D, Wang X, Yuan L, Hao L and Wang D: Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity. Biomed Rep 9: 339-344, 2018.
APA
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., & Wang, D. (2018). Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity. Biomedical Reports, 9, 339-344. https://doi.org/10.3892/br.2018.1139
MLA
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., Wang, D."Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity". Biomedical Reports 9.4 (2018): 339-344.
Chicago
Xiao, J., Wang, D., Wang, X., Yuan, L., Hao, L., Wang, D."Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity". Biomedical Reports 9, no. 4 (2018): 339-344. https://doi.org/10.3892/br.2018.1139
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