Atrial fibrillation following treatment with paclitaxel: A case report

Zhao,Dehua; Chen,Jing; Liu,Xiaojun; Long,Xiaoqing; Cao,Lisha; Wang,Jisheng

doi:10.3892/br.2018.1158

December-2018 Volume 9 Issue 6

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December-2018 Volume 9 Issue 6

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Case Report

Atrial fibrillation following treatment with paclitaxel: A case report

Authors:
- Dehua Zhao
- Jing Chen
- Xiaojun Liu
- Xiaoqing Long
- Lisha Cao
- Jisheng Wang
View Affiliations / Copyright

Affiliations: Department of Clinical Pharmacy, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, Sichuan 621000, P.R. China, Department of Oncology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, Sichuan 621000, P.R. China
Pages: 540-544
|
Published online on: October 12, 2018

https://doi.org/10.3892/br.2018.1158
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Abstract

Paclitaxel (PTX) is an antimicrotubule agent, and is effective in treating a wide range of solid tumors. However, its use may lead to cardiovascular toxicities, the manifestations of which include arrhythmia, heart failure, acute myocardial ischemia and atrial fibrillation (AF). AF is among the severe reactions to the PTX cardiotoxicity, and a cause for substantial morbidity and mortality. However, the incidence of PTX-induced AF is reportedly low (1.0-1.7% worldwide), and few cases have been reported in the literature. Thus, to emphasize the need for awareness of this side effect of PTX among clinicians, the report herein presents a case of AF induced by PTX in a patient with non-small-cell carcinoma. A 51-year-old man experienced AF following treatment with PTX. Amiodarone and metoprolol were administered to the patient to control cardiac rhythm and rate. After 3 days, the electrocardiogram was normalized and indicated normal heart rate and rhythm. According to this case, thorough attention should be paid during PTX treatment to monitor for signs of AF or other abnormalities in cardiac function.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Atrial fibrillation following treatment with paclitaxel: A case report

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Abstract

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