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Article

Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk

  • Authors:
    • Jinyang Lu
    • Dandan Niu
    • Di Zheng
    • Quan Zhang
    • Wenhua Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Cardiology, The Third People's Hospital of Xuzhou, Xuzhou, Jiangsu 221003, P.R. China
  • Pages: 517-522
    |
    Published online on: October 19, 2018
       https://doi.org/10.3892/br.2018.1162
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Abstract

The aim of the present study was to observe the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) and antithrombin III (AT-III) in patients with acute coronary syndrome (ACS), and the combination of Global Registry of Acute Coronary Events (GRACE) score to determine the value of coronary heart disease risk stratification. A total of 309 patients admitted to the Affiliated Hospital of Xuzhou Medical University were enrolled. The patients were divided into two groups: The ACS (183 cases) and control (126 cases) groups. Blood levels of Lp-PLA2 and AT-III were measured. Based on GRACE score, the patients with ACS were divided into three subgroups: Low risk (GRACE score ≤108), middle risk (GRACE score 109-140) and high risk (GRACE score >140). The levels of Lp-PLA2 and AT-III were compared among different groups, and based on Gensini score, patients with ACS were divided into four groups by quartiles. Lp-PLA2 levels in the ACS group were significantly increased compared with the control group (P<0.05), but the AT-III levels were decreased compared with the control group (P<0.05). In the ACS group, Lp-PLA2 levels increased sequentially from the low risk to high risk subgroups (all P<0.05); compared with the low risk and middle risk subgroups, the AT-III activity levels were decreased in the high risk subgroup, and the Gensini scores were increased (all P<0.05). In the ACS group, with the increase of Gensini scores, the levels of Lp-PLA2 and AT-III exhibited increasing and decreasing trends, respectively (P<0.05). The logistic regression model demonstrated that Lp-PLA2 [odds ratio (OR) =1.077; P<0.001]; and GRACE score (OR=1.026; P=0.028) were risk factors, while AT-III was a protective factor (OR=0.958; P=0.012) for ACS. Correlation analysis indicated a positive association of Lp-PLA2 level with Gensini scores (r=0.52; P<0.01) and GRACE score (r=0.48; P<0.01), and a negative association between AT-III level and Gensini scores (r=-0.25; P<0.01) and GRACE scores (r=-0.34; P<0.01). The levels of Lp-PLA2 and AT-III exhibited predictive values in patients with ACS, and are associated with the severity of coronary artery stenosis.
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Spandidos Publications style
Lu J, Niu D, Zheng D, Zhang Q and Li W: Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk. Biomed Rep 9: 517-522, 2018.
APA
Lu, J., Niu, D., Zheng, D., Zhang, Q., & Li, W. (2018). Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk. Biomedical Reports, 9, 517-522. https://doi.org/10.3892/br.2018.1162
MLA
Lu, J., Niu, D., Zheng, D., Zhang, Q., Li, W."Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk". Biomedical Reports 9.6 (2018): 517-522.
Chicago
Lu, J., Niu, D., Zheng, D., Zhang, Q., Li, W."Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk". Biomedical Reports 9, no. 6 (2018): 517-522. https://doi.org/10.3892/br.2018.1162
Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Niu D, Zheng D, Zhang Q and Li W: Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk. Biomed Rep 9: 517-522, 2018.
APA
Lu, J., Niu, D., Zheng, D., Zhang, Q., & Li, W. (2018). Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk. Biomedical Reports, 9, 517-522. https://doi.org/10.3892/br.2018.1162
MLA
Lu, J., Niu, D., Zheng, D., Zhang, Q., Li, W."Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk". Biomedical Reports 9.6 (2018): 517-522.
Chicago
Lu, J., Niu, D., Zheng, D., Zhang, Q., Li, W."Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk". Biomedical Reports 9, no. 6 (2018): 517-522. https://doi.org/10.3892/br.2018.1162
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