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Review Open Access

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)

  • Authors:
    • Juthamas Yosudjai
    • Sopit Wongkham
    • Siwanon Jirawatnotai
    • Worasak Kaewkong
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Siriraj Center for Research of Excellence (SiCORE) for System Pharmacology, Department of Pharmacology, Faculty of Medicine, Siriraj Medical School, Mahidol University, Bangkok 10700, Thailand
    Copyright: © Yosudjai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 147-155
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    Published online on: January 25, 2019
       https://doi.org/10.3892/br.2019.1188
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Abstract

Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post‑transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Yosudjai J, Wongkham S, Jirawatnotai S and Kaewkong W: Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomed Rep 10: 147-155, 2019.
APA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., & Kaewkong, W. (2019). Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomedical Reports, 10, 147-155. https://doi.org/10.3892/br.2019.1188
MLA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10.3 (2019): 147-155.
Chicago
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10, no. 3 (2019): 147-155. https://doi.org/10.3892/br.2019.1188
Copy and paste a formatted citation
x
Spandidos Publications style
Yosudjai J, Wongkham S, Jirawatnotai S and Kaewkong W: Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomed Rep 10: 147-155, 2019.
APA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., & Kaewkong, W. (2019). Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomedical Reports, 10, 147-155. https://doi.org/10.3892/br.2019.1188
MLA
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10.3 (2019): 147-155.
Chicago
Yosudjai, J., Wongkham, S., Jirawatnotai, S., Kaewkong, W."Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)". Biomedical Reports 10, no. 3 (2019): 147-155. https://doi.org/10.3892/br.2019.1188
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