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Article

Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis

  • Authors:
    • Hiromi Iwakawa
    • Tomiho Fukui
    • Tsutomu Fukuwatari
    • Shigeki Bamba
    • Masaya Sasaki
    • Tomoyuki Tsujikawa
    • Yukio Doi
    • Katsumi Shibata
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu, Shiga 520‑2194, Japan, Department of Nutrition, Faculty of Health and Nutrition, Shubun University, Ichinomiya, Aichi 491‑0938, Japan, Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522‑8533, Japan, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
  • Pages: 202-210
    |
    Published online on: February 5, 2019
       https://doi.org/10.3892/br.2019.1191
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Abstract

Few studies have investigated the association between dietary intake and blood concentrations of water‑soluble vitamins in patients with ulcerative colitis (UC). In the present study, vitamin concentrations were measured in the blood and urinary excretion of 23 outpatients with UC and compared against a control group of 20 healthy participants. A weighed food record procedure was used to ensure controlled macronutrient and vitamin intakes of the UC cohort. Individuals in the control group were given a semi‑purified diet for 8 days prior to assessment. Multiple linear regression analysis was used to identify important differences in vitamin concentrations, independent of sex, age and other confounding variables. The blood concentrations of vitamins B2, C, niacin and folate were markedly lower in the patients with UC than those in the control group, and the renal clearance of vitamins B1, B6, B12 and folate was notably higher in the UC cohort. It was concluded that vitamins B2, C, niacin and folate were at significantly lower concentrations in patients with UC following adjustment for coexisting factors. The lower levels of niacin may be partially due to impaired reabsorption. Chronic inflammation, common in patients with UC, with may contribute to the lower levels of other vitamins by rendering amino acid and carbohydrate metabolism into a hypermetabolic state. As the role of vitamins in metabolic activity is constant and pervasive, nutritional management including the application of water‑soluble vitamins appears important for patients suffering from UC.
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Copy and paste a formatted citation
Spandidos Publications style
Iwakawa H, Fukui T, Fukuwatari T, Bamba S, Sasaki M, Tsujikawa T, Doi Y and Shibata K: Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis. Biomed Rep 10: 202-210, 2019.
APA
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T. ... Shibata, K. (2019). Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis. Biomedical Reports, 10, 202-210. https://doi.org/10.3892/br.2019.1191
MLA
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T., Doi, Y., Shibata, K."Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis". Biomedical Reports 10.3 (2019): 202-210.
Chicago
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T., Doi, Y., Shibata, K."Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis". Biomedical Reports 10, no. 3 (2019): 202-210. https://doi.org/10.3892/br.2019.1191
Copy and paste a formatted citation
x
Spandidos Publications style
Iwakawa H, Fukui T, Fukuwatari T, Bamba S, Sasaki M, Tsujikawa T, Doi Y and Shibata K: Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis. Biomed Rep 10: 202-210, 2019.
APA
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T. ... Shibata, K. (2019). Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis. Biomedical Reports, 10, 202-210. https://doi.org/10.3892/br.2019.1191
MLA
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T., Doi, Y., Shibata, K."Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis". Biomedical Reports 10.3 (2019): 202-210.
Chicago
Iwakawa, H., Fukui, T., Fukuwatari, T., Bamba, S., Sasaki, M., Tsujikawa, T., Doi, Y., Shibata, K."Blood concentrations and renal clearance of water‑soluble vitamins in outpatients with ulcerative colitis". Biomedical Reports 10, no. 3 (2019): 202-210. https://doi.org/10.3892/br.2019.1191
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