Open Access

Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization

  • Authors:
    • Dimitra Moragianni
    • George Dryllis
    • Panagiotis Andromidas
    • Rachil Kapeta-Korkouli
    • Evangelia Kouskouni
    • Ilias Pessach
    • Petros Papalexis
    • Antigoni Kodonaki
    • Nikolaos Athanasiou
    • Avraham Pouliakis
    • Stavroula Baka
  • View Affiliations

  • Published online on: February 15, 2019     https://doi.org/10.3892/br.2019.1194
  • Pages: 231-237
  • Copyright: © Moragianni et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Assisted reproductive techniques including in vitro fertilization (IVF) are being used increasingly worldwide and screening for genital tract infections (GTIs) is recommended prior to treatment as their presence may affect the success rate of IVF. The current study aimed to assess the possible associations between GTI‑associated factors and reproductive outcome in a group of reproductive age fertile females and infertile females receiving IVF. A total of 111 infertile women enrolled in an IVF programme (Group A) and 104 fertile women (mothers of at least one child; Group B) underwent microbiological screening of vaginal and cervical samples. All samples were cultured using different protocols for aerobic pathogens, bacterial vaginosis (BV), Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis and human papilloma virus (HPV). Although each group were comparable in age, more infertile women were >30 years (P=0.0064), had a higher education level (P=0.0001) and were smokers (P=0.007). Only BV (P=0.0013) was more prevalent in Group A. Of the 111 infertile females who were scheduled for IVF, 32 females had a successful pregnancy (Group C) and 79 females exhibited IVF failure (Group D). Tubal factor (P=0.012), estradiol‑2 (E2) levels <2,500 pg/ml (P=0.0009) and Mycoplasma infection (P=0.003) were identified to be the strongest predictors of IVF failure. The current study determined certain GTI‑associated factors that may contribute to infertility in Greek females of reproductive age as well as other risk factors associated with failure in patients undergoing IVF. Further studies are required to confirm this conclusion.
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April-2019
Volume 10 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Moragianni D, Dryllis G, Andromidas P, Kapeta-Korkouli R, Kouskouni E, Pessach I, Papalexis P, Kodonaki A, Athanasiou N, Pouliakis A, Pouliakis A, et al: Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization. Biomed Rep 10: 231-237, 2019.
APA
Moragianni, D., Dryllis, G., Andromidas, P., Kapeta-Korkouli, R., Kouskouni, E., Pessach, I. ... Baka, S. (2019). Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization. Biomedical Reports, 10, 231-237. https://doi.org/10.3892/br.2019.1194
MLA
Moragianni, D., Dryllis, G., Andromidas, P., Kapeta-Korkouli, R., Kouskouni, E., Pessach, I., Papalexis, P., Kodonaki, A., Athanasiou, N., Pouliakis, A., Baka, S."Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization". Biomedical Reports 10.4 (2019): 231-237.
Chicago
Moragianni, D., Dryllis, G., Andromidas, P., Kapeta-Korkouli, R., Kouskouni, E., Pessach, I., Papalexis, P., Kodonaki, A., Athanasiou, N., Pouliakis, A., Baka, S."Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing in vitro fertilization". Biomedical Reports 10, no. 4 (2019): 231-237. https://doi.org/10.3892/br.2019.1194