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Article

Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia

  • Authors:
    • Rury Mega Wahyuni
    • Takako Utsumi
    • Juniastuti
    • Yoshihiko Yano
    • Ignatia Sinta Murti
    • Mochamad Amin
    • Laura Navika Yamani
    • Anittaqwa Istimagfiroh
    • Priyo Budi Purwono
    • Soetjipto
    • Maria Inge Lusida
    • Yoshitake Hayashi
  • View Affiliations / Copyright

    Affiliations: Indonesia‑Japan Collaborative Research Center for Emerging and Re‑emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Campus C, Surabaya 60115, Indonesia, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Internal Medicine, Faculty of Medicine, Mulawarman University, Samarinda 75119, Indonesia
  • Pages: 303-310
    |
    Published online on: March 22, 2019
       https://doi.org/10.3892/br.2019.1202
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Abstract

Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) are life‑threatening conditions frequently associated with chronic hepatitis B virus (HBV) infection in Asian countries, including Indonesia. HBV genotypes and several specific mutations are associated with disease progression. To clarify the geographical variation in viral characteristics, HBV genotypes and gene mutations were investigated in patients with advanced liver disease (ALD) in Samarinda, East Kalimantan, Indonesia. Sera were collected from 41 patients with ALD at Abdul Wahab Sjahranie Hospital and HBV carriers from Red Cross Center blood bank in Samarinda, and screened for hepatitis B surface antigen and hepatitis B e‑antigen. Liver function data were obtained from the medical records from each patient. HBV genotype and gene mutations were determined by polymerase chain reaction sequencing. Analysis of HBV isolates indicated that genotype B was the most frequent genotype, at 85.4 and 97.8%, followed by C, at 14.6 and 2.2%, in patients with ALD and in HBV carriers, respectively. The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers. The presence of HBV genotype B and certain HBV gene mutations were characteristic of patients with ALD in East Kalimantan.
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1 

Khan M, Dong JJ, Acharya SK, Dhagwahdorj Y, Abbas Z, Jafri SMW, Mulyono DH, Tozun N and Sarin SK: Hepatology issues in Asia: Perspective from regional leaders. J Gastroenterol Hepatol. 19 (Suppl 7):S419–S430. 2004. View Article : Google Scholar

2 

Purwono PB, Juniastuti Amin M, Bramanthi R, Nursidah Resi EM, Wahyuni RM, Yano Y, Soetjipto Hotta H, et al: Hepatitis B virus infection in Indonesia 15 years after adoption of a universal infant vaccination program: Possible impacts of low birth dose coverage and a vaccine-escape mutant. Am J Trop Med Hyg. 95:674–679. 2016.PubMed/NCBI View Article : Google Scholar

3 

Lindh M, Andersson AS and Gusdal A: Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - large-scale analysis using a new genotyping method. J Infect Dis. 175:1285–1293. 1997.PubMed/NCBI

4 

Fattovich G, Bortolotti F and Donato F: Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors. J Hepatol. 48:335–352. 2008.PubMed/NCBI View Article : Google Scholar

5 

Nishida N, Tokunaga K and Mizokami M: Genome-Wide Association Study Reveals Host Genetic Factors for Liver Diseases. J Clin Transl Hepatol. 1:45–50. 2013.PubMed/NCBI View Article : Google Scholar

6 

Mizokami M, Orito E, Ohba K, Ikeo K, Lau JY and Gojobori T: Constrained evolution with respect to gene overlap of hepatitis B virus. J Mol Evol. 44 (Suppl 1):S83–S90. 1997.PubMed/NCBI

7 

Heriyanto DS, Yano Y, Utsumi T, Anggorowati N, Rinonce HT, Lusida MI, et al: Mutations Within Enhancer II and BCP Regions of Hepatitis B Virus in Relation to ALDs in Patients Infected With Subgenotype B3 in Indonesia. J Med Virol. 84:44–51. 2012.PubMed/NCBI View Article : Google Scholar

8 

Zhang X and Ding HG: Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma. World J Hepatol. 7:1282–1286. 2015.PubMed/NCBI View Article : Google Scholar

9 

Suppiah J, Mohd Zain R, Bahari N, Haji Nawi S and Saat Z: G1896A Precore mutation and association with HBeAg status, genotype and clinical status in patients with chronic hepatitis B. Hepat Mon. 15:e31490:2015.PubMed/NCBI View Article : Google Scholar

10 

Utsumi T, Yano Y and Hotta H: Molecular epidemiology of hepatitis B virus in Asia. World J Med Genet. 4:19–26. 2014.PubMed/NCBI View Article : Google Scholar

11 

Sunbul M: Hepatitis B virus genotypes: Global distribution and clinical importance. World J Gastroenterol. 20:5427–5434. 2014.PubMed/NCBI View Article : Google Scholar

12 

Huang Y and Lok AS: Viral factors and outcomes of chronic HBV infection. Am J Gastroenterol. 106:93–95. 2011.PubMed/NCBI View Article : Google Scholar

13 

Mulyanto Depamede SN, Surayah K, Tsuda F, Ichiyama K, Takahashi M and Okamoto H: A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: Identification of two novel subgenotypes, B8 and C7. Arch Virol. 154:1047–1059. 2009.PubMed/NCBI View Article : Google Scholar

14 

Darmawan E, Turyadi KE, El-Khobar KE, Nursanty NK, Thedja MD and Muljono DH: Seroepidemiology and occult hepatitis B virus infection in young adults in Banjarmasin, Indonesia. J Med Virol. 87:199–207. 2015.PubMed/NCBI View Article : Google Scholar

15 

Sugauchi F, Mizokami M, Orito E, Ohno T, Kato H, Suzuki S, Kimura Y, Ueda R, Butterworth LA and Cooksley WG: A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: Complete genome sequence and phylogenetic relatedness. J Gen Virol. 82:883–892. 2001.PubMed/NCBI View Article : Google Scholar

16 

Tateno Y, Imanishi T, Miyazaki S, Fukami-Kobayashi K, Saitou N, Sugawara H and Gojobori T: DNA Data Bank of Japan (DDBJ) for genome scale research in life science. Nucleic Acids Res. 30:27–30. 2002.PubMed/NCBI

17 

Benson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J and Sayers EW: GenBank. Nucleic Acids Res. 41 (D1):D36–D42. 2013.PubMed/NCBI View Article : Google Scholar

18 

Lusida MI, Nugrahaputra VE, Soetjipto Handajani R, Nagano-Fujii M, Sasayama M, Utsumi T and Hotta H: Novel subgenotypes of hepatitis B virus genotypes C and D in Papua, Indonesia. J Clin Microbiol. 46:2160–2166. 2008.PubMed/NCBI View Article : Google Scholar

19 

Kumar S, Stecher G and Tamura K: MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 33:1870–1874. 2016.PubMed/NCBI View Article : Google Scholar

20 

Abe A, Inoue K, Tanaka T, Kato J, Kajiyama N, Kawaguchi R, Tanaka S, Yoshiba M and Kohara M: Quantitation of hepatitis B virus genomic DNA by real-time detection PCR. J Clin Microbiol. 37:2899–2903. 1999.PubMed/NCBI

21 

Fearnside PM: Transmigration in Indonesia: Lessons from its environmental and social impacts. Environ Manage. 21:553–570. 1997. View Article : Google Scholar

22 

Truong BX, Seo Y, Yano Y, Ho PTT, Phuong TM, Long DV, Son NT, Long NC, Kato H, Hayashi Y, et al: Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam. Int J Mol Med. 19:293–299. 2007.PubMed/NCBI

23 

Marcellin P: Hepatitis C: The clinical spectrum of the disease. J Hepatol. 31 (Suppl 1):9–16. 1999.PubMed/NCBI

24 

Gowda S, Desai PB, Hull VV, Math AAK, Vernekar SN and Kulkarni SS: A review on laboratory liver function tests. Pan Afr Med J. 3(17)2009.PubMed/NCBI View Article : Google Scholar

25 

Giannini EG, Testa R and Savarino V: Liver enzyme alteration: A guide for clinicians. CMAJ. 172:367–379. 2005.PubMed/NCBI

26 

Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM and Weinman SA: Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology. 122:366–375. 2002.PubMed/NCBI

27 

Giannini E, Botta F, Fasoli A, Ceppa P, Risso D, Lantieri PB, Celle G and Testa R: Progressive liver functional impairment is associated with an increase in AST/ALT ratio. Dig Dis Sci. 44:1249–1253. 1999.PubMed/NCBI

28 

Giannini E, Risso D, Botta F, Chiarbonello B, Fasoli A, Malfatti F, Romagnoli P, Testa E, Ceppa P and Testa R: Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease. Arch Intern Med. 163:218–224. 2003.PubMed/NCBI View Article : Google Scholar

29 

Wang ZX, Jiang CP, Cao Y, Zhang G, Chen WB and Ding YT: Preoperative serum liver enzyme markers for predicting early recurrence after curative resection of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 14:178–185. 2015.PubMed/NCBI View Article : Google Scholar

30 

Chen CH, Lee CM, Lu SN, Changchien CS, Eng HL, Huang CM, Wang JH, Hung CH and Hu TH: Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol. 43:6000–6006. 2005.PubMed/NCBI View Article : Google Scholar

31 

Kim JK, Chang HY, Lee JM, Baatarkhuu O, Yoon YJ, Park JY, Kim DY, Han KH, Chon CY and Ahn SH: Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma. J Med Virol. 81:1002–1008. 2009.PubMed/NCBI View Article : Google Scholar

32 

Araujo OC, Barros JJ, do Ó KM, Nabuco LC, Luz CA, Perez RM, Niel C, Villela-Nogueira CA and Araujo NM: Genetic variability of hepatitis B and C viruses in Brazilian patients with and without hepatocelullar carcinoma. J Med Virol. 86:217–223. 2014.PubMed/NCBI View Article : Google Scholar

33 

Yuan J, Zhou B, Tanaka Y, Kurbanov F, Orito E, Gong Z, Xu L, Lu J, Jiang X, Lai W, et al: Hepatitis B virus (HBV) genotypes/subgenotypes in China: Mutations in core promoter and precore/core and their clinical implications. J Clin Virol. 39:87–93. 2007.PubMed/NCBI View Article : Google Scholar

34 

Lee JH, Hong SP, Jang ES, Park SJ, Hwang SG, Kang SK and Jeong SH: Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B. J Med Virol. 87:993–998. 2015.PubMed/NCBI View Article : Google Scholar

35 

Lok AS, Akarca U and Greene S: Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci USA. 91:4077–4081. 1994.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wahyuni RM, Utsumi T, Juniastuti , Yano Y, Murti IS, Amin M, Yamani LN, Istimagfiroh A, Purwono PB, Soetjipto , Soetjipto , et al: Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia. Biomed Rep 10: 303-310, 2019.
APA
Wahyuni, R.M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I.S., Amin, M. ... Hayashi, Y. (2019). Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia. Biomedical Reports, 10, 303-310. https://doi.org/10.3892/br.2019.1202
MLA
Wahyuni, R. M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I. S., Amin, M., Yamani, L. N., Istimagfiroh, A., Purwono, P. B., Soetjipto, ., Lusida, M. I., Hayashi, Y."Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia". Biomedical Reports 10.5 (2019): 303-310.
Chicago
Wahyuni, R. M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I. S., Amin, M., Yamani, L. N., Istimagfiroh, A., Purwono, P. B., Soetjipto, ., Lusida, M. I., Hayashi, Y."Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia". Biomedical Reports 10, no. 5 (2019): 303-310. https://doi.org/10.3892/br.2019.1202
Copy and paste a formatted citation
x
Spandidos Publications style
Wahyuni RM, Utsumi T, Juniastuti , Yano Y, Murti IS, Amin M, Yamani LN, Istimagfiroh A, Purwono PB, Soetjipto , Soetjipto , et al: Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia. Biomed Rep 10: 303-310, 2019.
APA
Wahyuni, R.M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I.S., Amin, M. ... Hayashi, Y. (2019). Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia. Biomedical Reports, 10, 303-310. https://doi.org/10.3892/br.2019.1202
MLA
Wahyuni, R. M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I. S., Amin, M., Yamani, L. N., Istimagfiroh, A., Purwono, P. B., Soetjipto, ., Lusida, M. I., Hayashi, Y."Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia". Biomedical Reports 10.5 (2019): 303-310.
Chicago
Wahyuni, R. M., Utsumi, T., Juniastuti, ., Yano, Y., Murti, I. S., Amin, M., Yamani, L. N., Istimagfiroh, A., Purwono, P. B., Soetjipto, ., Lusida, M. I., Hayashi, Y."Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia". Biomedical Reports 10, no. 5 (2019): 303-310. https://doi.org/10.3892/br.2019.1202
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