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Article

Role of adiponectin in ovarian follicular development and ovarian reserve

  • Authors:
    • Zaher Merhi
    • Ali A. Bazzi
    • Elizabeth A. Bonney
    • Erkan Buyuk
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10463, USA, Department of Obstetrics and Gynecology, St. John Hospital and Medical Center, Detroit, MI 48236, USA, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT 05401, USA, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology and Women's Health, Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
  • Pages: 337-342
    |
    Published online on: May 17, 2019
       https://doi.org/10.3892/br.2019.1213
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Abstract

Adiponectin levels are associated with anti‑Müllerian hormone (AMH) and kisspeptin levels in non‑ovarian tissues. The objective of the present study was to investigate the association between adiponectin and the genes important for ovarian follicular development and ovarian reserve, specifically AMH and kisspeptin, and their corresponding receptors. In the first experiment, the mRNA levels of anti‑Müllerian hormone (amh) and its receptor (Amhr2), as well as those of kisspeptin (Kiss1) and its receptor (Kiss1r), were quantified by reverse transcription‑polymerase chain reaction analysis in the ovaries of two groups of mice [adiponectin‑knockout (KO) vs. control] that underwent oophorectomy. The second experiment measured follicular phase serum AMH and follicular fluid adiponectin levels in 25 women who underwent controlled ovarian hyperstimulation for in vitro fertilization. Compared with the control mice, adiponectin‑KO mice had 6.5 times lower Kiss1 mRNA levels (P=0.009) and a tendency for lower ovarian Kiss1r mRNA expression levels (P=0.06). However, adiponectin‑KO mice had significantly higher Amhr2 mRNA levels (P=0.01). In all women participants, there was a positive correlation between serum AMH and follicular fluid adiponectin concentrations (r=0.54, P=0.006). The findings of the present study indicate that adiponectin may play a role in ovarian physiology through its impact on genes crucial for ovarian follicular development and ovarian reserve, such as kisspeptin and AMH. Understanding the role of adiponectin in ovarian function may improve our knowledge of the pathophysiology underlying ovulatory dysfunction in obese women, who usually have low adiponectin levels, and overcome reproductive barriers.
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Copy and paste a formatted citation
Spandidos Publications style
Merhi Z, Bazzi AA, Bonney EA and Buyuk E: Role of adiponectin in ovarian follicular development and ovarian reserve. Biomed Rep 10: 337-342, 2019.
APA
Merhi, Z., Bazzi, A.A., Bonney, E.A., & Buyuk, E. (2019). Role of adiponectin in ovarian follicular development and ovarian reserve. Biomedical Reports, 10, 337-342. https://doi.org/10.3892/br.2019.1213
MLA
Merhi, Z., Bazzi, A. A., Bonney, E. A., Buyuk, E."Role of adiponectin in ovarian follicular development and ovarian reserve". Biomedical Reports 10.6 (2019): 337-342.
Chicago
Merhi, Z., Bazzi, A. A., Bonney, E. A., Buyuk, E."Role of adiponectin in ovarian follicular development and ovarian reserve". Biomedical Reports 10, no. 6 (2019): 337-342. https://doi.org/10.3892/br.2019.1213
Copy and paste a formatted citation
x
Spandidos Publications style
Merhi Z, Bazzi AA, Bonney EA and Buyuk E: Role of adiponectin in ovarian follicular development and ovarian reserve. Biomed Rep 10: 337-342, 2019.
APA
Merhi, Z., Bazzi, A.A., Bonney, E.A., & Buyuk, E. (2019). Role of adiponectin in ovarian follicular development and ovarian reserve. Biomedical Reports, 10, 337-342. https://doi.org/10.3892/br.2019.1213
MLA
Merhi, Z., Bazzi, A. A., Bonney, E. A., Buyuk, E."Role of adiponectin in ovarian follicular development and ovarian reserve". Biomedical Reports 10.6 (2019): 337-342.
Chicago
Merhi, Z., Bazzi, A. A., Bonney, E. A., Buyuk, E."Role of adiponectin in ovarian follicular development and ovarian reserve". Biomedical Reports 10, no. 6 (2019): 337-342. https://doi.org/10.3892/br.2019.1213
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