Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
August-2019 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2019 Volume 11 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Essentials of recurrent aphthous stomatitis (Review)

  • Authors:
    • César Rivera
  • View Affiliations / Copyright

    Affiliations: Oral Medicine and Pathology Research Group, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca, Maule 3460000, Chile
  • Pages: 47-50
    |
    Published online on: June 11, 2019
       https://doi.org/10.3892/br.2019.1221
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recurrent aphthous stomatitis (RAS), also known as canker sores, is the most common disease of the oral mucosa. Unlike caries and periodontal disease, patients with RAS are unable to prevent it. The clinical picture of RAS is characterized by recurrent episodes of solitary or multiple painful ulcerations without association with systemic diseases. The objective of this review is to present the essential characteristics of RAS, including its definition, pathogenesis, clinical and microscopic characteristics, proposed experimental models and recommended pharmacological management. This understanding can serve as a theoretical framework for research proposals.
View Figures

Figure 1

Figure 2

View References

1 

Edgar NR, Saleh D and Miller RA: Recurrent aphthous stomatitis: A review. J Clin Aesthet Dermatol. 10:26–36. 2017.PubMed/NCBI

2 

Preeti L, Magesh K, Rajkumar K and Karthik R: Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 15:252–256. 2011.PubMed/NCBI View Article : Google Scholar

3 

Jin LJ, Lamster IB, Greenspan JS, Pitts NB, Scully C and Warnakulasuriya S: Global burden of oral diseases: Emerging concepts, management and interplay with systemic health. Oral Dis. 22:609–619. 2016.PubMed/NCBI View Article : Google Scholar

4 

BMJ Best Practice: Aphthous ulcers 2018. https://bestpractice.bmj.com/topics/en-us/564/guidelines. Accessed April 26, 2018.

5 

Shulman JD, Beach MM and Rivera-Hidalgo F: The prevalence of oral mucosal lesions in U.S. adults: data from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Dent Assoc. 135:1279–86. 2004.PubMed/NCBI View Article : Google Scholar

6 

Shulman JD: Prevalence of oral mucosal lesions in children and youths in the USA. Int J Paediatr Dent. 15:89–97. 2005.PubMed/NCBI View Article : Google Scholar

7 

Davatchi F, Tehrani-Banihashemi A, Jamshidi AR, Chams-Davatchi C, Gholami J, Moradi M, Akhlaghi M, Foroozanfar MH, Barghamdi M, Noorolahzadeh E, et al: The prevalence of oral aphthosis in a normal population in Iran: a WHO-ILAR COPCORD study. Arch Iran Med. 11:207–209. 2008.PubMed/NCBI

8 

Safadi RA: Prevalence of recurrent aphthous ulceration in Jordanian dental patients. BMC Oral Health. 9(31)2009. View Article : Google Scholar

9 

Patil S, Reddy SN, Maheshwari S, Khandelwal S, Shruthi D and Doni B: Prevalence of recurrent aphthous ulceration in the Indian Population. J Clin Exp Dent. 6:e36–e40. 2014.PubMed/NCBI View Article : Google Scholar

10 

Wang H, He F, Xu C, Fang C and Peng J: Clinical analysis for oral mucosal disease in 21 972 cases. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 43:779–783. 2018.(In Chinese). PubMed/NCBI View Article : Google Scholar

11 

Akintoye SO and Greenberg MS: Recurrent aphthous stomatitis. Dent Clin North Am. 58:281–297. 2014.PubMed/NCBI View Article : Google Scholar

12 

Chavan M, Jain H, Diwan N, Khedkar S, Shete A and Durkar S: Recurrent aphthous stomatitis: A review. J Oral Pathol Med. 41:577–583. 2012.PubMed/NCBI View Article : Google Scholar

13 

Gallo Cde B, Mimura MA and Sugaya NN: Psychological stress and recurrent aphthous stomatitis. Clinics (Sao Paulo). 64:645–648. 2009.PubMed/NCBI View Article : Google Scholar

14 

Rivera C: Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach. J Oral Res. 6:245–251. 2017. View Article : Google Scholar

15 

Wu J, Chen ZP, Shang AQ, Wang WW, Chen ZN, Tao YJ, Zhou Y and Wang WX: Systemic bioinformatics analysis of recurrent aphthous stomatitis gene expression profiles. Oncotarget. 8:111064–111072. 2017.PubMed/NCBI View Article : Google Scholar

16 

Mimura MAM, Borra RC, Hirata CHW and de Oliveira Penido N: Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. J Oral Pathol Med. 46:821–828. 2017.PubMed/NCBI View Article : Google Scholar

17 

Ślebioda Z, Krawiecka E, Szponar E and Dorocka-Bobkowska B: Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS). BMC Oral Health. 17(158)2017.PubMed/NCBI View Article : Google Scholar

18 

Slezakova S, Borilova Linhartova P, Masopustova L, Bartova J, Petanova J, Kuklinek P, Fassmann A, Dusek L and Izakovicova Holla L: Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. J Oral Pathol Med. 47:434–439. 2018.PubMed/NCBI View Article : Google Scholar

19 

Karasneh J, Bani-Hani M, Alkhateeb A, Hassan A, Alzoubi F and Thornhill M: TLR2, TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis. J Oral Pathol Med. 44:857–863. 2015.PubMed/NCBI View Article : Google Scholar

20 

Karakus N, Yigit S, Rustemoglu A, Kalkan G and Bozkurt N: Effects of interleukin (IL)-6 gene polymorphisms on recurrent aphthous stomatitis. Arch Dermatol Res. 306:173–180. 2014.PubMed/NCBI View Article : Google Scholar

21 

Alkhateeb A, Karasneh J, Abbadi H, Hassan A and Thornhill M: Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis. J Oral Pathol Med. 42:741–746. 2013.PubMed/NCBI View Article : Google Scholar

22 

Guimarães AL, Correia-Silva Jde F, Sá AR, Victória JM, Diniz MG, Costa Fde O and Gomez RS: Investigation of functional gene polymorphisms IL-1beta, IL-6, IL-10 and TNF-alpha in individuals with recurrent aphthous stomatitis. Arch Oral Biol. 52:268–272. 2007.PubMed/NCBI View Article : Google Scholar

23 

Schemel-Suárez M, López-López J and Chimenos-Küstner E: Oral ulcers: Differential diagnosis and treatment. Med Clin (Barc). 145:499–503. 2015.(In Spanish). PubMed/NCBI View Article : Google Scholar

24 

Cui RZ, Bruce AJ and Rogers RS III: Recurrent aphthous stomatitis. Clin Dermatol. 34:475–481. 2016.PubMed/NCBI View Article : Google Scholar

25 

Rogers RS III: Recurrent aphthous stomatitis: Clinical characteristics and associated systemic disorders. Semin Cutan Med Surg. 16:278–283. 1997.PubMed/NCBI

26 

Lalla RV, Choquette LE, Feinn RS, Zawistowski H, Latortue MC, Kelly ET and Baccaglini L: Multivitamin therapy for recurrent aphthous stomatitis: A randomized, double-masked, placebo-controlled trial. J Am Dent Assoc. 143:370–376. 2012.PubMed/NCBI View Article : Google Scholar

27 

Rajan B, Ahmed J, Shenoy N, Denny C, Ongole R and Binnal A: Assessment of quality of life in patients with chronic oral mucosal diseases: A questionnaire-based study. Perm J. 18:e123–e127. 2014.PubMed/NCBI View Article : Google Scholar

28 

Albrektson M, Hedström L and Bergh H: Recurrent aphthous stomatitis and pain management with low-level laser therapy: A randomized controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol. 117:590–594. 2014.PubMed/NCBI View Article : Google Scholar

29 

Vucicevic Boras V and Savage NW: Recurrent aphthous ulcerative disease: Presentation and management. Aust Dent J. 52:10–15; quiz 73. 2007.PubMed/NCBI View Article : Google Scholar

30 

Tappuni AR, Kovacevic T, Shirlaw PJ and Challacombe SJ: Clinical assessment of disease severity in recurrent aphthous stomatitis. J Oral Pathol Med. 42:635–641. 2013.PubMed/NCBI View Article : Google Scholar

31 

Brocklehurst P, Tickle M, Glenny AM, Lewis MA, Pemberton MN, Taylor J, Walsh T, Riley P and Yates JM: Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. CD005411. 2012.PubMed/NCBI View Article : Google Scholar

32 

Belenguer-Guallar I, Jiménez-Soriano Y and Claramunt-Lozano A: Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent. 6:e168–e174. 2014.PubMed/NCBI View Article : Google Scholar

33 

Karavana Hizarcioğlu SY, Sezer B, Güneri P, Veral A, Boyacioğlu H, Ertan G and Epstein JB: Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: An in vivo animal study. Int J Oral Maxillofac Surg. 40:973–978. 2011.PubMed/NCBI View Article : Google Scholar

34 

Karavana SY, Gökçe EH, Rençber S, Özbal S, Pekçetin C, Güneri P and Ertan G: A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: In vivo/in vitro examinations. Int J Nanomedicine. 7:5693–5704. 2012.PubMed/NCBI View Article : Google Scholar

35 

Fernandes Teixeira FM, Figueiredo Pereira Md, Gomes Ferreira NL, Miranda GM and Andrade Aguiar JL: Spongy film of cellulosic polysaccharide as a dressing for aphthous stomatitis treatment in rabbits. Acta Cir Bras. 29:231–236. 2014.PubMed/NCBI View Article : Google Scholar

36 

Dan S, Jinwei Z, Qiang Z, Jianwei S and Weijun Z: Exploring the molecular mechanism and biomarker of recurrent aphthous stomatitis based on gene expression microarray. Clin Lab. 63:249–253. 2017.PubMed/NCBI View Article : Google Scholar

37 

Swain SK, Gupta S and Sahu MC: Recurrent aphthous ulcers-still a challenging clinical entity. Apollo Med. 14:202–206. 2017. View Article : Google Scholar

38 

Staines K and Greenwood M: Aphthous ulcers (recurrent). BMJ Clin Evid. 1303:2015.PubMed/NCBI

39 

Scully C: Clinical practice. Aphthous ulceration. N Engl J Med. 355:165–172. 2006.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Rivera C: Essentials of recurrent aphthous stomatitis (Review). Biomed Rep 11: 47-50, 2019.
APA
Rivera, C. (2019). Essentials of recurrent aphthous stomatitis (Review). Biomedical Reports, 11, 47-50. https://doi.org/10.3892/br.2019.1221
MLA
Rivera, C."Essentials of recurrent aphthous stomatitis (Review)". Biomedical Reports 11.2 (2019): 47-50.
Chicago
Rivera, C."Essentials of recurrent aphthous stomatitis (Review)". Biomedical Reports 11, no. 2 (2019): 47-50. https://doi.org/10.3892/br.2019.1221
Copy and paste a formatted citation
x
Spandidos Publications style
Rivera C: Essentials of recurrent aphthous stomatitis (Review). Biomed Rep 11: 47-50, 2019.
APA
Rivera, C. (2019). Essentials of recurrent aphthous stomatitis (Review). Biomedical Reports, 11, 47-50. https://doi.org/10.3892/br.2019.1221
MLA
Rivera, C."Essentials of recurrent aphthous stomatitis (Review)". Biomedical Reports 11.2 (2019): 47-50.
Chicago
Rivera, C."Essentials of recurrent aphthous stomatitis (Review)". Biomedical Reports 11, no. 2 (2019): 47-50. https://doi.org/10.3892/br.2019.1221
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team