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Article

Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

Corrigendum in: /10.3892/br.2020.1326
  • Authors:
    • Amita Rai
    • Meghna Gill
    • Manas Kinra
    • Raghavendra Shetty
    • Nandakumar Krishnadas
    • C. Mallikarjuna Rao
    • Suhani Sumalatha
    • Nitesh Kumar
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India, Ecron Acunova Ltd., Manipal, Karnataka 576104, India, Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
  • Pages: 79-84
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/br.2019.1226
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Abstract

Catechin is an active ingredient of green tea. It is reported to inhibit corticosteroid‑induced anxiety and depression‑like symptoms. Considering the complex nature of depression, effects of catechin need to be studied in a clinically relevant depression model. The present study was designed to explore the antidepressant effect of catechin in Sprague Dawley rats subjected to chronic unpredictable mild stress (CUMS). Animals were subjected to CUMS and treated with (+)‑catechin (50 mg/kg) or escitalopram (10 mg/kg) orally; a CUMS control and a vehicle control that was not exposed to CUMS were also established. Various stressors were applied daily in an unpredictable manner for 8 weeks achieve CUMS. Sucrose preference test were performed after 4 and 8 weeks and forced swim tests (FSTs) were conducted at weeks 4, 6 and 8. At the end of week 8, animals were sacrificed and the brain homogenate was studied for antioxidant parameters. Compared with the vehicle control, animals of the CUMS control group showed a significant decrease in sucrose intake. Catechin and escitalopram treatment significantly improved the sucrose intake compared with the CUMS control. A similar trend was observed in the FSTs, where catechin and escitalopram treatment significantly reduced the immobility time, and antioxidant parameters, including catalase, glutathione and superoxide dismutase levels were recovered in treated animals compared with the CUMS control. Thus, it was concluded that catechin reverses CUMS‑induced depression in rats by ameliorating oxidative stress, which may help to develop a novel treatment for major depressive disorder.
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1 

Patel V: Cultural factors and international epidemiology. Br Med Bull. 57:33–45. 2001.PubMed/NCBI View Article : Google Scholar

2 

Lépine JP and Briley M: The increasing burden of depression. Neuropsychiatr Dis Treat. 7 (Suppl 1):S3–S7. 2011.PubMed/NCBI View Article : Google Scholar

3 

Wang F and Pereira A: Neuromodulation, emotional feelings and affective disorders. Mens Sana Monogr. 14:5–29. 2016.PubMed/NCBI View Article : Google Scholar

4 

Slavich GM and Irwin MR: From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol Bull. 140:774–815. 2014.PubMed/NCBI View Article : Google Scholar

5 

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, et al: Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology. 76:197–205. 2017.PubMed/NCBI View Article : Google Scholar

6 

Anisman H, Merali Z and Hayley S: Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders. Prog Neurobiol. 85:1–74. 2008.PubMed/NCBI View Article : Google Scholar

7 

Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M and Ng CH: Adjunctive nutraceuticals for depression: A systematic review and meta-analyses. Am J Psychiatry. 173:575–587. 2016.PubMed/NCBI View Article : Google Scholar

8 

Behr GA, Moreira JC and Frey BN: Preclinical and clinical evidence of antioxidant effects of antidepressant agents: Implications for the pathophysiology of major depressive disorder. Oxid Med Cell Longev. 2012(609421)2012.PubMed/NCBI View Article : Google Scholar

9 

Ni CX, Gong H, Liu Y, Qi Y, Jiang CL and Zhang JP: Green tea consumption and the risk of liver cancer: A meta-analysis. Nutr Cancer. 69:211–220. 2017.PubMed/NCBI View Article : Google Scholar

10 

Syed Hussein SS, Kamarudin MN and Kadir HA: (+)-catechin attenuates NF-κB activation through regulation of Akt, MAPK, and AMPK signaling pathways in LPS-induced BV-2 microglial cells. Am J Chin Med. 43:927–952. 2015.PubMed/NCBI View Article : Google Scholar

11 

Zhu BT, Shim JY, Nagai M and Bai HW: Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. Xenobiotica. 38:130–146. 2008.PubMed/NCBI View Article : Google Scholar

12 

Rai A, Das S, Chamallamudi MR, Nandakumar K, Shetty R, Gill M, Sumalatha S, Devkar R, Gourishetti K and Kumar N: Evaluation of the aphrodisiac potential of a chemically characterized aqueous extract of Tamarindus indica pulp. J Ethnopharmacol. 210:118–124. 2018.PubMed/NCBI View Article : Google Scholar

13 

Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H and Hahm DH: Chronic administration of catechin decreases depression and anxiety-like behaviors in a rat model using chronic corticosterone injections. Biomol Ther (Seoul). 21:313–322. 2013.PubMed/NCBI View Article : Google Scholar

14 

Gill M, Kinra M, Rai A, Chamallamudi MR and Kumar N: Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model. Neuroreport. 29:134–140. 2018.PubMed/NCBI View Article : Google Scholar

15 

Ministry of Environment and Forests and Climate Change Government of India: Compendium of CPCSEA 2018. Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), New Delhi, 2018. http://cpcsea.nic.in/WriteReadData/userfiles/file/Compendium%20of%20CPCSEA.pdf.

16 

Zanwar AA, Badole SL, Shende PS, Hegde MV and Bodhankar SL: Chapter 21 - Antioxidant role of catechin in health and disease. In: Polyphenols in human health and disease. Watson RR, Preedy VR and Zibadi S (eds.) Academic Press, San Diego, CA. pp267–271. 2014. View Article : Google Scholar

17 

Castagné V, Porsolt RD and Moser P: Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. Eur J Pharmacol. 616:128–133. 2009.PubMed/NCBI View Article : Google Scholar

18 

Kumar N, Choudhary A, Tiwari A, Rasal A, Jetti R and Rao CM: Evaluation of hepatoprotective effect of aqueous extract of Schrebera swietenioides Bark against carbon tetrachloride-induced toxicity in wistar rats. Advanced Sci Lett. 23:1917–1920. 2017. View Article : Google Scholar

19 

Kumar N, Rai A, Reddy ND, Shenoy RR, Mudgal J, Bansal P, Mudgal PP, Arumugam K, Udupa N, Sharma N and Rao CM: Improved in vitro and in vivo hepatoprotective effects of liposomal silymarin in alcohol-induced hepatotoxicity in Wistar rats. Pharmacol Rep. (In Press). View Article : Google Scholar

20 

Luo DD, An SC and Zhang X: Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress. Brain Res Bull. 77:8–12. 2008.PubMed/NCBI View Article : Google Scholar

21 

Cheruku S, Chamallamudi M, Ramalingayya G, Biswas S, Gourishetti K, Nandakumar K, Devkar R, Mallik SB, Nampoothiri M and Kumar N: Neuroprotective potential of methanolic extract of Saraca asoca bark against doxorubicin-induced neurotoxicity. Pharmacog Mag. 15:309–316. 2019. View Article : Google Scholar

22 

Vaváková M, Ďuračková Z and Trebatická J: Markers of oxidative stress and neuroprogression in depression disorder. Oxid Med Cell Longev. 2015(898393)2015.PubMed/NCBI View Article : Google Scholar

23 

Thakare VN, Patil RR, Oswal RJ, Dhakane VD, Aswar MK and Patel BM: Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. J Psychopharmacol. 32:223–235. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Rai A, Gill M, Kinra M, Shetty R, Krishnadas N, Rao CM, Sumalatha S and Kumar N: Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326. Biomed Rep 11: 79-84, 2019.
APA
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C.M. ... Kumar, N. (2019). Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326. Biomedical Reports, 11, 79-84. https://doi.org/10.3892/br.2019.1226
MLA
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S., Kumar, N."Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326". Biomedical Reports 11.2 (2019): 79-84.
Chicago
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S., Kumar, N."Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326". Biomedical Reports 11, no. 2 (2019): 79-84. https://doi.org/10.3892/br.2019.1226
Copy and paste a formatted citation
x
Spandidos Publications style
Rai A, Gill M, Kinra M, Shetty R, Krishnadas N, Rao CM, Sumalatha S and Kumar N: Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326. Biomed Rep 11: 79-84, 2019.
APA
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C.M. ... Kumar, N. (2019). Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326. Biomedical Reports, 11, 79-84. https://doi.org/10.3892/br.2019.1226
MLA
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S., Kumar, N."Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326". Biomedical Reports 11.2 (2019): 79-84.
Chicago
Rai, A., Gill, M., Kinra, M., Shetty, R., Krishnadas, N., Rao, C. M., Sumalatha, S., Kumar, N."Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress Corrigendum in /10.3892/br.2020.1326". Biomedical Reports 11, no. 2 (2019): 79-84. https://doi.org/10.3892/br.2019.1226
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