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Article

Evaluation of miR‑135a/b expression in endometriosis lesions

  • Authors:
    • Rafaella Petracco
    • Ana Cristina de Oliveira Dias
    • Hugh S. Taylor
    • Álvaro Petracco
    • Mariângela Badalotti
    • João da Rosa Michelon
    • Daniel Rodrigo Marinowic
    • Marta Hentschke
    • Pamella Nunes de Azevedo
    • Gabriele Zanirati
    • Denise Cantarelli Machado
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90610‑000, Brazil, Quatro G P&D Ltda., Porto Alegre, Rio Grande do Sul 90619‑900, Brazil, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520‑8063, USA
  • Pages: 181-187
    |
    Published online on: September 2, 2019
       https://doi.org/10.3892/br.2019.1237
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Abstract

The pathogenesis of endometriosis is not clear; however, microRNAs (miRNAs/miRs) are involved in the pathogenesis. miRNAs are short noncoding RNAs involved in post‑transcriptional regulation of gene expression by silencing the expression of target genes. The expression of miR‑135a/b is associated with endometrial receptivity and implantation; the expression is also associated with the expression of certain genes, including homeobox protein Hox‑A10 (HOXA‑10). The present study investigated the expression of miR‑135a/b in eutopic and ectopic endometrium tissues throughout the different phases of the menstrual cycle. Samples of ectopic endometriosis lesions and eutopic endometrium tissue from 23 patients who underwent laparoscopic surgery were obtained and analyzed. miRNA was extracted and the expression levels of miR‑135a/b were determined by reverse transcription quantitative polymerase chain reaction assays using U6 as a housekeeping control. The expression levels of miR‑135a and miR‑135b in endometriosis lesions were decreased compared with the levels in endometrium tissue. However, miR‑135a/b expression levels were increased in the secretory phase compared with the proliferative phase in endometriosis lesions. The increased expression of miR‑135a/b during the secretory phase compared with the proliferative phase suggested that these genes serve a determinant role in the homeostasis of reproductive tissue. Therefore, the expression of genes may affect endometrial functioning, impairing embryo implantation.
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1 

Benagiano G and Brosens I: History of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 20:449–463. 2006.PubMed/NCBI View Article : Google Scholar

2 

Sensky TE and Liu DT: Endometriosis: Associations with menorrhagia, infertility and oral contraceptives. Int J Gynaecol Obstet. 17:573–576. 1980.PubMed/NCBI View Article : Google Scholar

3 

Houston DE: Evidence for the risk of pelvic endometriosis by age, race and socioeconomic status. Epidemiol Rev. 6:167–191. 1984.PubMed/NCBI View Article : Google Scholar

4 

Cramer DW and Missmer SA: The epidemiology of endometriosis. Ann N Y Acad Sci. 955:11–22; discussion 34-16, 396-406. 2002.PubMed/NCBI View Article : Google Scholar

5 

Giudice LC and Kao LC: Endometriosis. Lancet. 364:1789–1799. 2004.PubMed/NCBI View Article : Google Scholar

6 

Du H and Taylor HS: Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 25:2082–2086. 2007.PubMed/NCBI View Article : Google Scholar

7 

Lee B, Du H and Taylor HS: Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod. 80:79–85. 2009.PubMed/NCBI View Article : Google Scholar

8 

Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y and Honjo H: Endometriosis: The pathophysiology as an estrogen-dependent disease. J Steroid Biochem Mol Biol. 83:149–155. 2002.PubMed/NCBI View Article : Google Scholar

9 

Jiang X, Hitchcock A, Bryan EJ, Watson RH, Englefield P, Thomas EJ and Campbell IG: Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci. Cancer Res. 56:3534–3539. 1996.PubMed/NCBI

10 

Gogusev J, Bouquet de Jolinière J, Telvi L, Doussau M, du Manoir S, Stojkoski A and Levardon M: Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization. Hum Genet. 105:444–451. 1999.PubMed/NCBI View Article : Google Scholar

11 

Kosugi Y, Elias S, Malinak LR, Nagata J, Isaka K, Takayama M, Simpson JL and Bischoff FZ: Increased heterogeneity of chromosome 17 aneuploidy in endometriosis. Am J Obstet Gynecol. 180:792–797. 1999.PubMed/NCBI View Article : Google Scholar

12 

Albertsen HM, Chettier R, Farrington P and Ward K: Genome-wide association study link novel loci to endometriosis. PLoS One. 8(e58257)2013.PubMed/NCBI View Article : Google Scholar

13 

Fung JN and Montgomery GW: Genetics of endometriosis: State of the art on genetic risk factors for endometriosis. Best Pract Res Clin Obstet Gynaecol. 50:61–71. 2018.PubMed/NCBI View Article : Google Scholar

14 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009.PubMed/NCBI View Article : Google Scholar

15 

Croce CM: Oncogenes and cancer. N Engl J Med. 358:502–511. 2008.PubMed/NCBI View Article : Google Scholar

16 

Ohlsson Teague EM, Van der Hoek KH, Van der Hoek MB, Perry N, Wagaarachchi P, Robertson SA, Print CG and Hull LM: MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol. 23:265–275. 2009.PubMed/NCBI View Article : Google Scholar

17 

Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A and Surico N: Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotechnol. 2010(369549)2010.PubMed/NCBI View Article : Google Scholar

18 

Wu Y, Kajdacsy-Balla A, Strawn E, Basir Z, Halverson G, Jailwala P, Wang Y, Wang X, Ghosh S and Guo SW: Transcriptional characterizations of differences between eutopic and ectopic endometrium. Endocrinology. 147:232–246. 2006.PubMed/NCBI View Article : Google Scholar

19 

Eyster KM, Klinkova O, Kennedy V and Hansen KA: Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium. Fertil Steril. 88:1505–1533. 2007.PubMed/NCBI View Article : Google Scholar

20 

Petracco RG, Kong A, Grechukhina O, Krikun G and Taylor HS: Global gene expression profiling of proliferative phase endometrium reveals distinct functional subdivisions. Reprod Sci. 19:1138–1145. 2012.PubMed/NCBI View Article : Google Scholar

21 

Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y and Taylor HS: MicroRNA 135 regulates HOXA10 expression in endometriosis. J Clin Endocrinol Metab. 96:E1925–E1933. 2011.PubMed/NCBI View Article : Google Scholar

22 

Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 67: 817-821, 1997.

23 

Noyes RW, Hertig AT and Rock J: Dating the endometrial biopsy. Am J Obstet Gynecol. 122:262–263. 1975.PubMed/NCBI View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

25 

Bjorkman S and Taylor HS: MicroRNAs in endometriosis: Biological function and emerging biomarker candidates†. Biol Reprod. 100:1135–1146. 2019.PubMed/NCBI View Article : Google Scholar

26 

Klemmt PAB and Starzinski-Powitz A: Molecular and cellular pathogenesis of endometriosis. Curr Womens Health Rev. 14:106–116. 2018.PubMed/NCBI View Article : Google Scholar

27 

Coutinho LM, Ferreira MC, Rocha ALL, Carneiro MM and Reis FM: New biomarkers in endometriosis. Adv Clin Chem. 89:59–77. 2019.PubMed/NCBI View Article : Google Scholar

28 

Pan Q, Luo X, Toloubeydokhti T and Chegini N: The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression. Mol Hum Reprod. 13:797–806. 2007.PubMed/NCBI View Article : Google Scholar

29 

Reis FM, Petraglia F and Taylor RN: Endometriosis: Hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update. 19:406–418. 2013.PubMed/NCBI View Article : Google Scholar

30 

Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, Baracat EC and Serafini PC: The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: A review. J Assist Reprod Genet. 27:701–710. 2010.PubMed/NCBI View Article : Google Scholar

31 

Naqvi H, Mamillapalli R, Krikun G and Taylor HS: Endometriosis located proximal to or remote from the uterus differentially affects uterine gene expression. Reprod Sci. 23:186–191. 2016.PubMed/NCBI View Article : Google Scholar

32 

Santamaria X, Massasa EE and Taylor HS: Migration of cells from experimental endometriosis to the uterine endometrium. Endocrinology. 153:5566–5574. 2012.PubMed/NCBI View Article : Google Scholar

33 

Santamaria X and Taylor H: MicroRNA and gynecological reproductive diseases. Fertil Steril. 101:1545–1551. 2014.PubMed/NCBI View Article : Google Scholar

34 

Cho S, Mutlu L, Grechukhina O and Taylor HS: Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril. 103:1252–1260, e1251. 2015.PubMed/NCBI View Article : Google Scholar

35 

Borghese B, Zondervan KT, Abrao MS, Chapron C and Vaiman D: Recent insights on the genetics and epigenetics of endometriosis. Clin Genet. 91:254–264. 2017.PubMed/NCBI View Article : Google Scholar

36 

Krishnamoorthy K and Decherney AH: Genetics of endometriosis. Clin Obstet Gynecol. 60:531–538. 2017.PubMed/NCBI View Article : Google Scholar

37 

Neilson JR, Zheng GX, Burge CB and Sharp PA: Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev. 21:578–589. 2007.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Petracco R, Dias AC, Taylor HS, Petracco Á, Badalotti M, Michelon Jd, Marinowic DR, Hentschke M, de Azevedo PN, Zanirati G, Zanirati G, et al: Evaluation of miR‑135a/b expression in endometriosis lesions. Biomed Rep 11: 181-187, 2019.
APA
Petracco, R., Dias, A.C., Taylor, H.S., Petracco, Á., Badalotti, M., Michelon, J.d. ... Machado, D.C. (2019). Evaluation of miR‑135a/b expression in endometriosis lesions. Biomedical Reports, 11, 181-187. https://doi.org/10.3892/br.2019.1237
MLA
Petracco, R., Dias, A. C., Taylor, H. S., Petracco, Á., Badalotti, M., Michelon, J. d., Marinowic, D. R., Hentschke, M., de Azevedo, P. N., Zanirati, G., Machado, D. C."Evaluation of miR‑135a/b expression in endometriosis lesions". Biomedical Reports 11.4 (2019): 181-187.
Chicago
Petracco, R., Dias, A. C., Taylor, H. S., Petracco, Á., Badalotti, M., Michelon, J. d., Marinowic, D. R., Hentschke, M., de Azevedo, P. N., Zanirati, G., Machado, D. C."Evaluation of miR‑135a/b expression in endometriosis lesions". Biomedical Reports 11, no. 4 (2019): 181-187. https://doi.org/10.3892/br.2019.1237
Copy and paste a formatted citation
x
Spandidos Publications style
Petracco R, Dias AC, Taylor HS, Petracco Á, Badalotti M, Michelon Jd, Marinowic DR, Hentschke M, de Azevedo PN, Zanirati G, Zanirati G, et al: Evaluation of miR‑135a/b expression in endometriosis lesions. Biomed Rep 11: 181-187, 2019.
APA
Petracco, R., Dias, A.C., Taylor, H.S., Petracco, Á., Badalotti, M., Michelon, J.d. ... Machado, D.C. (2019). Evaluation of miR‑135a/b expression in endometriosis lesions. Biomedical Reports, 11, 181-187. https://doi.org/10.3892/br.2019.1237
MLA
Petracco, R., Dias, A. C., Taylor, H. S., Petracco, Á., Badalotti, M., Michelon, J. d., Marinowic, D. R., Hentschke, M., de Azevedo, P. N., Zanirati, G., Machado, D. C."Evaluation of miR‑135a/b expression in endometriosis lesions". Biomedical Reports 11.4 (2019): 181-187.
Chicago
Petracco, R., Dias, A. C., Taylor, H. S., Petracco, Á., Badalotti, M., Michelon, J. d., Marinowic, D. R., Hentschke, M., de Azevedo, P. N., Zanirati, G., Machado, D. C."Evaluation of miR‑135a/b expression in endometriosis lesions". Biomedical Reports 11, no. 4 (2019): 181-187. https://doi.org/10.3892/br.2019.1237
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