Long‑term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports

Sasatani,Yuika; Okauchi,Shinichiro; Ohara,Gen; Kagohashi,Katsunori; Satoh,Hiroaki

doi:10.3892/br.2019.1267

Long‑term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports

Authors:
- Yuika Sasatani
- Shinichiro Okauchi
- Gen Ohara
- Katsunori Kagohashi
- Hiroaki Satoh
View Affiliations

Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba‑Mito Kyodo General Hospital, Mito, Ibaraki 310‑0015, Japan
Published online on: December 20, 2019 https://doi.org/10.3892/br.2019.1267
Pages: 121-124

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Ninjinyoeito, is a traditional herbal (Kampo) medicine which is administered to patients with debilitating diseases in North‑East Asia. Ninjinyoeito has been reported to be effective against loss of physical strength, fatigue and loss of appetite in patients with wasting diseases. The present study described long‑term maintenance of body weight with ninjinyoueito in 2 terminal patients with chronic respiratory diseases. The first patient was a 75‑year‑old with chronic obstructive pulmonary disease (COPD) who took ninjinyoueito for ≥5 years and the second patient was a 72‑year‑old man with metastatic lung cancer with combined pulmonary fibrosis and emphysema (CPFE) who took ninjinyoueito for ≥1 year. Both of them maintained their physique and nutritional status during the terminal stages of disease and there were no adverse effects observed in these 2 patients which could be attributed to ninjinyoueito. The results suggest that ninjinyoueito may be a supplementary treatment for the maintenance of nutritional status in patients with a chronic respiratory disease accompanied by wasting, such as COPD.

View Figures

View References

1	Kagohashi K, Tamura T, Ohara G and Satoh H: Effect of a traditional herbal medicine, hangekobokuto, on the sensation of a lump in the throat in patients with respiratory diseases. Biomed Rep. 4:384–386. 2016.PubMed/NCBI View Article : Google Scholar
2	Oteki T, Ishikawa A, Sasaki Y, Ohara G, Kagohashi K, Kurishima K and Satoh H: Effect of rikkunshi-to treatment on chemotherapy-induced appetite loss in patients with lung cancer: A prospective study. Exp Ther Med. 11:243–246. 2016.PubMed/NCBI View Article : Google Scholar
3	Kuniaki H, Akihiko T, Tetsuya H, Hatsuko M, Tomoko K, Shin O, Sojiro K, Mayumi Y, Fumihiro Y, Shintaro S, et al: Improvement in frailty in a patient with severe chronic obstructive pulmonary disease after ninjin'yoeito therapy: A case report. Front Nutr. 5(71)2018.PubMed/NCBI View Article : Google Scholar
4	Arring NM, Millstine D, Marks LA and Nail LM: Ginseng as a treatment for fatigue: A systematic review. J Altern Complement Med. 24:624–633. 2018.PubMed/NCBI View Article : Google Scholar
5	Scheid V, Bensky D, Ellis A and Barolet R: Chinese Herbal Medicine Formulas and Strategies. Scheid V (ed). Eastland Press, Inc., Seattle WA, pp505-618, 2009.
6	Suzuki T, Yamamoto A, Ohsawa M, Motoo Y, Mizukami H and Makino T: Ninjin'yoeito and ginseng extract prevent oxaliplatin-induced neurodegeneration in PC12 cells. J Nat Med. 69:531–537. 2015.PubMed/NCBI View Article : Google Scholar
7	Tulic MK, Piche T and Verhasselt V: Lung-gut cross-talk: Evidence, mechanisms and implications for the mucosal inflammatory diseases. Clin Exp Allergy. 46:519–528. 2016.PubMed/NCBI View Article : Google Scholar
8	Raguso CA and Luthy C: Nutritional status in chronic obstructive pulmonary disease: Role of hypoxia. Nutrition. 27:138–143. 2011.PubMed/NCBI View Article : Google Scholar
9	Zawada K, Bratek A and Krysta K: Psychological distress and social factors in patients with asthma and chronic obstructive lung disease. Psychiatr Danub. 27 (Suppl 1):S462–S464. 2015.PubMed/NCBI
10	Schols AM, Slangen J, Volovics L and Wouters EF: Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 157:1791–1797. 1998.PubMed/NCBI View Article : Google Scholar
11	Kiss NK, Krishnasamy M and Isenring EA: The effect of nutrition intervention in lung cancer patients undergoing chemotherapy and/or radiotherapy: A systematic review. Nutr Cancer. 66:47–56. 2014.PubMed/NCBI View Article : Google Scholar
12	Kato S, Tamano M, Okamura A, Ozone S, Hoshino T, Takahashi S, Mugihara T and Yamauchi H: Clinical benefits of three major Jingizai formulas in chronic obstructive pulmonary disease. Sci Kampo Med. 40:172–176. 2016.(In Japanese).
13	Shergis JL, Di YM Zhang AL, Vlahos R, Helliwell R, Ye JM and Xue CC: Therapeutic potential of Panax ginseng and ginsenosides in the treatment of chronic obstructive pulmonary disease. Complement Ther Med. 22:944–953. 2014.PubMed/NCBI View Article : Google Scholar
14	Shergis JL, Thien F, Worsnop CJ, Lin L, Zhang AL, Wu L, Chen Y, Xu Y, Langton D, Da Costa C, et al: 12-month randomised controlled trial of ginseng extract for moderate COPD. Thorax. 74:539–545. 2019.PubMed/NCBI View Article : Google Scholar
15	Meguro M, Barley EA, Spencer S and Jones PW: Development and validation of an improved, COPD-specific version of the St. George Respiratory Questionnaire. Chest. 132:456–463. 2007.PubMed/NCBI View Article : Google Scholar
16	Gupta N, Pinto LM, Morogan A and Bourbeau J: The COPD assessment test: A systematic review. Eur Respir J. 44:873–884. 2014.PubMed/NCBI View Article : Google Scholar
17	Parshall MB, Mapel DW, Rice L, Williams A and O'Reilly J: Predictive validity of short-form health survey [36 items] scales for chronic obstructive pulmonary disease exacerbation. Heart Lung. 37:356–365. 2008.PubMed/NCBI View Article : Google Scholar
18	Ogawa-Ochiai K and Kawasaki K: Panax ginseng for frailty-related disorders: A Review. Front Nutr. 5(140)2019.PubMed/NCBI View Article : Google Scholar